Rybelsus Interactions
There are 273 drugs known to interact with Rybelsus (semaglutide), along with 6 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 15 are major, 257 are moderate, and 1 is minor.
- View all 273 medications that may interact with Rybelsus
- View Rybelsus alcohol/food interactions (2)
- View Rybelsus disease interactions (6)
Most frequently checked interactions
View interaction reports for Rybelsus (semaglutide) and the medicines listed below.
- albuterol
- amlodipine
- aspirin
- atorvastatin
- bupropion
- duloxetine
- famotidine
- Farxiga (dapagliflozin)
- gabapentin
- glimepiride
- hydrochlorothiazide
- ibuprofen
- Jardiance (empagliflozin)
- levothyroxine
- lisinopril
- losartan
- magnesium oxide
- meloxicam
- metformin
- metoprolol
- montelukast
- omeprazole
- pantoprazole
- rosuvastatin
- tamsulosin
- tramadol
- trazodone
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Rybelsus alcohol/food interactions
There are 2 alcohol/food interactions with Rybelsus (semaglutide).
Rybelsus disease interactions
There are 6 disease interactions with Rybelsus (semaglutide) which include:
- suicidal behavior and ideation
- thyroid cancer
- GI adverse events
- hypoglycemia
- pancreatitis
- retinopathy
Report options
More about Rybelsus (semaglutide)
- Rybelsus consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (297)
- Drug images
- Latest FDA alerts (4)
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- FDA approval history
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
