Rybelsus and Vomiting: What Users Say

• The...
• Taken for less than 1 month
• April 6, 2021

For Type 2 Diabetes "It’s been a week on Rybelsus 3mg. I feel pretty good (except for seasonal allergies). No nausea, no vomiting, no diarrhea, smaller appetite. I am prediabetic with BMI >30. I would like to lose 30 to 40 pounds. I think Rybelsus will help me. (Prior to taking Rybelsus, I was fasting (16-hour/8-hour) and exercising EVERY day and STILL gaining weight.) I think Rybelsus will help. I weigh daily, and I am beginning to see the numbers ever so slightly trend down. I am optimistic. I will start 7mg after 30 days. I hope to come back here and share my journey with you."

• Fat...
• Taken for 1 to 6 months
• March 27, 2021

For Type 2 Diabetes "My A1c has been hovering around 7, and my weight was creeping up, so my doc suggested this. I started on the 3, and the nausea and projectile vomiting were rough... indeed, I didn’t think I could handle it. Then I discovered if I take it when I wake in the small hours to pee, if I took it then, I had almost no problems. I’m now up to the 15mg dose, and so far I’ve gone from around 255lb to about 220lb and falling. Two whole jean sizes... haven’t done new labs yet... but the weight loss is remarkable... it’s also quite weird to essentially almost never feel hungry anymore."

• SSH...
• Taken for 1 to 6 months
• February 25, 2020

For Type 2 Diabetes "I have been on Rybelsus for 2 months. I started on the 3 mg and did fine, no side effects, and actually felt more awake and focused. Then I went to the 7 mg and was very nauseous and vomited almost nightly. It felt like my food never digested. I apparently am pretty sensitive to this medication and since my blood glucose and A1C have been good, I am taking this every other day, which has lessened the nausea and discomfort. I have lost 6 lbs in the past month and that has been great because I needed that. So we will see how this continues, but I feel pretty good."

• ATQ...
• Taken for less than 1 month
• March 13, 2023

For Type 2 Diabetes "I took my fourth dose of 3 mg Rybelsus this morning. I've followed all the directions, but it has been awful. I've been incredibly sick since the second day. I've been vomiting, nauseous, I've had a nonstop migraine, and every time I cough, vomit, sneeze, or gag, my entire upper body feels like it's being electrocuted. I emailed my doctor last night. Hopefully, I'll hear from her today. This is miserable."

• Fan...
• Taken for 1 to 6 months
• October 5, 2020

For Type 2 Diabetes "I have been on Rybelsus for 1.5 months. Can’t eat, and what I do eat makes me so nauseous that it all comes back up. I have lost 10 lbs, which is great, but if this upset stomach and throwing up do not go away, then it is not worth it. I’ll give it another week, but I think I will tell the doctor I am done. My sugar levels were high, and that is why he prescribed it to take along with Synjardy. Feeling sick all the time is not worth it."

• Joe...
• Taken for less than 1 month
• June 3, 2020

For Type 2 Diabetes "1st, I did not take Rybelsus to lose weight, only trying to get A1C down. For 10 days on this, I did not vomit, but the feeling is there, sometimes I have to gag myself to get that feeling to go away. Felt tired all the time, trouble sleeping, and my stomach always feels full. I don't have much of an appetite either, and oh boy, diarrhea the first 3 days almost seems like you can't leave the house and almost like uncontrollable, need to stay near the throne. 4-5 days later, the diarrhea seems to be better, but the nausea and vomiting feelings keep me away from this med. Also, if anyone likes to try this med, I suggest getting some ginger chew candy, it does help the nausea feelings. One more thing: if you are a guy, beware of this, your libido will go down :-("

• Lyn...
• Taken for less than 1 month
• July 21, 2021

For Type 2 Diabetes "My A1C inched up to 6.1 from 5.9. I've been on 2,000 mg metformin/day. Started on Rybelsus 3 mg. Days 1-4 were OK. Day 5 I started vomiting profusely and could not hold down any food or liquid. Did not take another one. Today is day 4 that I'm off the pills, and I still vomited this morning. And this set my diarrhea issues with metformin backward. Very upset as I don't think I needed this. I've never had these types of issues, terrible."

• rac...
• Taken for 1 to 6 months
• March 27, 2021

For Type 2 Diabetes "Been on Rybelsus for 3 months, along with Metformin and Glyburide. Overall, it has been great, with morning sugar in the 130 range from the 180s before. Haven’t done A1C, but I’m hopeful. Some stomach issues - feel bloated a lot, and one time had dry heaves. But I’ve adapted and found just eating less avoids the issues. A side benefit is lost about ten pounds without any effort, really. Only real issue is cost, Medicare coverage sucks on this drug."

• Anonymous
• March 26, 2022

For Type 2 Diabetes "Beware. My doctor had me transition to 7 mg after only being on the 3 mg for two weeks. I could not stop vomiting after taking the pills for 5 days. I lost a ton of weight but ended up in the hospital getting my gallbladder removed and not eating for two weeks."

• Mic...
• Taken for 1 to 6 months
• July 5, 2022

For Type 2 Diabetes "My first 30 days at 3 mg weren't bad. I enjoyed not feeling hungry and only experienced mild diarrhea after eating occasionally, though it wasn't triggered by specific foods, so I always needed a bathroom plan. In my last week of Month 1 on the 7 mg, I had watery diarrhea with nausea for 24-hour periods, 3 times in 10 days. I vomited one of those days. I haven't had my bloodwork checked, and I know I lost weight, but I also lost more than 3 days of my life sitting on a toilet. I ate nothing that would have triggered these episodes. Rybelsus has done one good thing - inspired my butt to get serious about my health without drugs."

• Typ...
• Taken for 1 to 6 months
• April 5, 2022

For Type 2 Diabetes "I was on Rybelsus as an add-on for my A1C control. This medication was okay at the 3 mg dose…for 2 weeks. Then when the dose was increased to 7 mg, I was nauseous every day, vomiting 4-5 times per week. I couldn’t eat, the mere thought of food or smell of food made me vomit. I ruined a day of vacation at Disney because I threw up 8 times in a 2-hour time span from this medication. It even began to interfere with my job (I’m a nurse-I can’t be throwing up multiple times a day). My A1C increased from 7.2 to 9.6 while on the medication, and I gained 8 pounds. I stopped taking it while waiting for my appointment with my provider, and I already feel 1,000 times better. I’m glad this medicine has worked for others, but I definitely don’t recommend."

• Lyn...
• Taken for 1 to 6 months
• December 18, 2021

For Type 2 Diabetes "I took 3 mg for 2 months and then started the 7 mg. The 3 mg I had heartburn, nausea, some diarrhea. Was uncomfortable but doable. But once on 7 mg, I had the same symptoms plus vomiting, constipation to the point of hemorrhoids, and severe heartburn to the point I almost went to the ER. I got out the label on this medicine, Rybelsus, and relooked up side effects symptoms on the computer. I immediately stopped on my own, messaging my doctor. Within 2 days, I felt so much better. This medicine is costly too, luckily I had insurance because I will not use this and it had to be disposed of. $ wasted."

• Joh...
• Taken for 1 to 6 months
• March 7, 2023

For Type 2 Diabetes "I started with the 3 mg. Within a week, my bowel movements became loose. Other than that, it was fine. Started the 7 mg after a month. Within a week, I was nauseated constantly, along with diarrhea. The nausea got worse, and diarrhea continued. At three weeks, I had to stop taking it. The very next day, nausea stopped, and I have normal bowel movements again. I do not recommend this medication. Also, vomiting was a relief a few times."

• Hop...
• Taken for 1 to 6 months
• January 7, 2022

"I've been on Rybelsus for about 6 weeks now and am up to the 7 mg dose. I was placed on it to help lose PCOS-induced weight gain. It took about a month to get used to (minor vomiting, nausea, constipation, and diarrhea during the adjustment). I've lost almost 15 lbs, my anxiety levels have plummeted, and my skin is the clearest it's been in ages. I no longer have sugar or processed carb cravings, which I think is helping all of this. I'm lucky that my insurance is fully covering the medication since it is pricey."

• Kat...
• Taken for 1 to 6 months
• May 21, 2022

For Type 2 Diabetes "I was on 3 mg for 3 months, tolerated great. Once I went to 7 mg, I thought I’m going crazy. Vomiting, constant brain fog, lightheaded, increased anxiety, food went through me, and my stools were like water... Horrible. I’m getting off of this medicine."

• kab...
• Taken for 1 to 6 months
• May 24, 2023

For Type 2 Diabetes "I started with the 3 mg, then 7 mg, and the fireworks started with the 14 mg. I started taking it the Saturday before Easter. The Tuesday after Easter, I started with diarrhea for about a week. My doctor said I may have diverticulitis and gave me an antibiotic. The diarrhea stopped for 2 weeks, then came back with a vengeance, and it brought vomiting and nausea with it. Like clockwork, every 4 days, the diarrhea would kick it off, followed by the nausea, and then the crescendo of puking my guts out. Then repeat 4 days later. I stopped taking it on a Monday, and that Friday got sick again. I read that it could take 4 to 5 weeks to get it out. It’s now 5 days, and I feel good finally. I did work on lowering my A1C, I think. I also changed my diet and started with a lot more exercise, and so far, things are good. I would avoid taking Semaglutide if possible. It didn’t work for me."

• Sue...
• Taken for less than 1 month
• June 12, 2022

For Type 2 Diabetes "I have only been on Rybelsus for 9 days. It’s horrible! I’m nauseous and dry heaving every morning. And now for the last two mornings, 15 minutes after taking it, my throat is burning. I also have nodules in my thyroid, and this medication is known to cause thyroid nodules and cancer of the thyroid. I don’t know why my doctor thought this medication was good for me. I’m going off."

• Men...
• Taken for 1 to 6 months
• November 27, 2022

For Type 2 Diabetes "I've had diabetes for 15 years, and these tablets are the worst thing I've ever taken. I've been on them for weeks because there's an extremely annoying shortage of Ozempic (I don't like needles, but I can't wait to go back to it). I'm constantly nauseous and often vomit randomly. I'm told by my nurse that it's not as effective as Ozempic either. And now I have slight retinopathy, which has never happened in 15 years."

• boo...
• Taken for 1 to 6 months
• October 6, 2024

For Type 2 Diabetes "I started 3 months ago because my glucose levels would not change and come down no matter what I did. I tried different diabetes tablets and alogliptons, so I started on 3 mg for 1 month, no problems. Then a month on 7 mg, sugars started to drop, and I started losing a bit of weight. Now I just started 14 mg, it stops me from eating much at all, very small amounts, and I have to stop. It takes 4 goes to get a small Sunday dinner down. My glucose is right down now, which is great as the next step was injection insulin instead. I take them when I get up, 30 minutes before food as directed. But I am having bouts of vomiting. I have to run to the toilet. It can be quickly after food or a few hours after. It's early days yet, hoping it will settle as I am definitely shrinking my stomach, which is good to keep weight off. I have lost 4 lb so far, I only need a stone and a half off and hope I go back to not being diabetic. The doctor will put me back on 7 mg if I'm still sick."

• Ari...
• Taken for 6 months to 1 year
• March 4, 2021

For Type 2 Diabetes "I had awful side effects with the 3 mg and 7 mg. Constant nausea and vomiting. I lost 12 pounds in 2 months. Once I went to 14 mg, I have no side effects. I’ve gained back the 12 pounds and am hungry all the time. My sugar stays low. I’m wondering if going back to 7 mg would help with my appetite."

• kee...
• Taken for 1 to 6 months
• October 15, 2021

For Type 2 Diabetes "I am on 3 mg for a month, constipation and stomach pain, occasional vomiting. The next month, 7 mg and side effect symptoms are worse: belching, rotten-tasting burps, stomach pain, vomiting food still on my stomach 24 hours later. I will try to persevere since some people say it gets better. Not going up to 14 mg next month till I see my A1C levels. My daily numbers are better, but I feel like I'm wrecking my digestion."

• Lou...
• Taken for less than 1 month
• May 11, 2022

For Type 2 Diabetes "I've been on this now for nearly 2 weeks. To help reduce blood glucose levels and boost my weight loss. I've lost 1 lb and have a loss of appetite, also nauseous most mornings if I don't eat after 30 mins of taking meds. Today I ate 2 biscuits with a cup of tea and vomited really bad, which I'm sure is related to this medication. As I feel absolutely fine now. Seems the side effects are the same as the majority here. I'll stick it out and increase the dose in 2 weeks."

• Lau...
• Taken for less than 1 month
• January 4, 2025

For Type 2 Diabetes "Positive results: it did help lower my sugar. It shut the 'food-obsessed voice' off in my head, and I had a reduced appetite. Lost weight. BUT...as the week progressed, I was nauseous and vomited frequently. Just miserable."

• Ryb...
• Taken for 1 to 6 months
• December 11, 2024

For Type 2 Diabetes "Occasionally feel like vomiting, but never do, in general, no issues. Does stop you from eating high-fat/sugar foods. Has sorted out my blood sugar levels and has been a great help with weight loss (about 12-15 kg in 6 months, bonus)."

• Edd...
• March 20, 2020

For Type 2 Diabetes "Throwing up from Rybelsus and covered in a rash from it."