Rybelsus Alternatives Compared
| Rybelsus | Ozempic | Metformin |
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| Rybelsus (semaglutide) | Ozempic (semaglutide) | Metformin |
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Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more |
Prescription only
Metformin improves how the body responds to insulin and it is effective for the treatment of type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side... View more |
Related suggestions Diabetes, Type 2
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| More about Rybelsus (semaglutide) | More about Ozempic (semaglutide) | More about Metformin | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Rybelsus has an average rating of 6.2 out of 10 from a total of 243 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 27% reported a negative effect. |
Ozempic has an average rating of 6.5 out of 10 from a total of 1310 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 26% reported a negative effect. |
Metformin has an average rating of 6.9 out of 10 from a total of 648 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
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See also: Rybelsus side effects in more detail. |
See also: Ozempic side effects in more detail. |
See also: metformin side effects in more detail. |
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| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Rybelsus prices |
View all Ozempic prices |
View all metformin prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other semaglutide brands include: Ozempic, Wegovy | Other semaglutide brands include: Rybelsus, Wegovy | Glumetza | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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168 hours |
168 hours |
4.5 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 264 drugs are known to interact with Rybelsus:
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A total of 264 drugs are known to interact with Ozempic:
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A total of 367 drugs are known to interact with metformin:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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September 20, 2019 |
N/A |
March 03, 1995 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.