Comparing Metformin vs Rybelsus
| Metformin | Rybelsus (semaglutide) |
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| Metformin | Rybelsus (semaglutide) |
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Prescription only
Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Related suggestions Type 2 Diabetes
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| More about Metformin | More about Rybelsus (semaglutide) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Metformin has an average rating of 6.9 out of 10 from a total of 653 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 19% reported a negative effect. |
Rybelsus has an average rating of 6.4 out of 10 from a total of 266 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 25% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Metformin prices |
View all Rybelsus prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Glumetza | Other semaglutide brands include: Ozempic, Wegovy | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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4.5 hours |
168 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 371 drugs are known to interact with Metformin:
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A total of 267 drugs are known to interact with Rybelsus:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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March 03, 1995 |
September 20, 2019 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.