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Medications for Insulin Resistance Syndrome (Metabolic Syndrome)

Other names: Impaired Fasting Glucose; Impaired Glucose Tolerance; Syndrome X

Insulin resistance is when the cells in your muscles, start ignoring or resisting the signal that the hormone insulin sends which tells these cells to uptake glucose (sugar) from the blood. Glucose is the body’s main source of energy, and we get it from grains, fruit, vegetables, and other foods that break down into carbohydrates. One in three Americans is reported to have insulin resistance. Insulin resistance may also be called low insulin sensitivity.

Experts believe that insulin resistance in addition to physical inactivity is a major reason behind the development of insulin resistance syndrome (also called the metabolic syndrome). Insulin resistance syndrome is a cluster of risk factors that includes obesity, insulin resistance, high blood pressure, and high cholesterol (dyslipidemia), and people with this deadly quartet are at a very high risk of death.

For more information about insulin resistance see here.

Drugs used to treat Insulin Resistance Syndrome

The following list of medications are in some way related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
metformin Off-label 7.5 57 reviews
Rx B N X

Generic name: metformin systemic

Drug class: non-sulfonylureas

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off-label: Yes

Humulin R Rate Add review
OTC B N X

Generic name: insulin regular systemic

Drug class: insulin

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

insulin regular 10 1 review
Rx/OTC B N X

Generic name: insulin regular systemic

Brand names:  Humulin R, Novolin R

Drug class: insulin

For consumers: dosage, interactions, side effects

Novolin R Rate Add review
OTC B N X

Generic name: insulin regular systemic

Drug class: insulin

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Learn more about Insulin Resistance Syndrome

Symptoms and treatments

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.