Comparing Januvia vs Trulicity

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Januvia sitagliptin

Trulicity dulaglutide

Januvia is a DDP-4 inhibitor that is used in addition to other medications for the treatment of type 2 diabetes. Rarely, it may cause joint pain, skin reactions, pancreatitis, or an allergic reaction... View more

Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more

Prescription only

Ratings & Reviews

View all 114 reviews

View all 856 reviews

Drug Class

Dipeptidyl peptidase 4 inhibitors

Incretin mimetics

Side Effects

See the full Januvia side effects document.

Common side effects include: diarrhea, frequent bowel movements, nausea, and retching.

See the full Trulicity side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 tablet
Dosage	100 mg
Per Unit^*	$17.61
Cost^*	$528.16

View all Januvia prices

Quantity	2 mL
Dosage	0.75 mg/0.5 mL
Per Unit^*	$445.51
Cost^*	$891.01

View all Trulicity prices

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Generic Availability

Dosage Form(s) Available

Oral tablet

Subcutaneous solution

Brand Names

N/A

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

12.4 hours

120 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 271 drugs are known to interact with Januvia:

2 major drug interactions (5 brand and generic names)
245 moderate drug interactions (1175 brand and generic names)
24 minor drug interactions (273 brand and generic names)

A total of 241 drugs are known to interact with Trulicity:

2 major drug interactions (5 brand and generic names)
217 moderate drug interactions (1115 brand and generic names)
22 minor drug interactions (263 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

October 16, 2006

September 18, 2014

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer