Trulicity and Headaches: What Users Say

• pra...
• Taken for less than 1 month
• September 24, 2019

For Type 2 Diabetes "3rd Week on Trulicity 0.75 (read my review below for 1st week). I did not have major side effects except headache for 1st week. The second week, day 2 after the shot was miserable. I had diarrhea continuously from 6 pm to 9 pm - luckily I was home by then and could not even digest water. I went to bed. Day 3 and after was uneventful. I have seen a pattern that diet matters. Assuming you take your shot on Monday: Day 2 and 3 Diet (Tue & Wed): No heavy carbs/sugary foods, eat a lot of veggies (avoid cauliflower, broccoli, legumes), apple, pear is fine. Full-fat yogurt (no sweetened). Drink plenty of water (no soda or sparkling water), but don't overdo it. Keep the dinner light. Day 4 - Thu: Add bread or rice for lunch (80 gms). Pasta is also fine. Mozzarella cheese (or any fresh cheese - 100 gm) for dinner with vegetables. Day 5 - Friday: Same as day 4. Day 6 and 7 (Sat & Sun): Get back to your normal diet. Day 1 (shot is due): Follow Day 2 diet. I will keep posting the updates."

• Jan...
• September 19, 2020

For Type 2 Diabetes "When I first started Trulicity, I thought it was the end of me. Between the diarrhea, vomiting, headaches, stomach pain, and loss of appetite, I could barely leave my bed. My physician said it would take time to improve, at least 4 to 6 weeks. He moved my dose to 0.75 mg, with no metformin. This drug changed my life."

• Anonymous
• Taken for 1 to 6 months
• October 16, 2019

For Type 2 Diabetes "I started a month ago, my BSL was out of control and Forxiga was giving me nasty side effects. I have to admit it has been FANTASTIC, my BSL has never been that good and the side effects have been minimal. I experience constipation the day after I have my injection, I do have some occasional headaches but that’s it. I am extremely thankful to have been prescribed Trulicity, so far it has only been a blessing. Before I stated I was very pessimistic given the reviews about the side effects that unfortunately some people have experienced. I am 100% satisfied with this product and I guess each individual reacts differently as with any other medication."

• Luc...
• Taken for less than 1 month
• October 19, 2019

For Type 2 Diabetes "If you want to feel like walking death, this monstrosity of a 'medication' is for you! I have taken 1 dose of Trulicity, 2 days ago...never again. Sitting on the toilet with explosive diarrhea & projectile vomiting into the tub all night long, my body is killing me, my head is pounding, I'm beyond bloated, the sulfur burps are ridiculous & I feel like I'm getting stabbed in the stomach. It is the same exact thing I went through with Ozempic...don't ever take that stuff either."

• com...
• Taken for 1 to 2 years
• November 6, 2020

For Type 2 Diabetes "Started the Trulicity medication over 2 years ago. Have had no appetite since. Now I have lost 105 lbs and look like a stick man. I kept telling Dr., but he was not worried, saying A1C looked great. I feel horrible all the time. My family is very worried about me. My Dr. has left the practice, and my new one is very concerned that it has gone this far. This drug is really hard on my body. I feel weak all the time, headaches, no appetite. I can eat half of a burger and feel sick and unable to eat any more. I have an appointment with my new Dr. in a week. I hope he has an alternative, as there will be nothing left of me within a couple more months. Do not take this drug. Oh my, I wish my other Dr. would have listened to me before I got this bad. Went from 315 lbs to 187 lbs now. Enough is enough."

• Emi...
• February 12, 2020

For Type 2 Diabetes "I was on Trulicity for 6 months. The first 5 months, my symptoms were mild enough that I could manage them. Around 5 months in, I started getting extremely bloated, gassy, sulfur burps, extreme fatigue, diarrhea, nausea, vomiting, and headaches. I would get sick 2-3 days after my injection. Since stopping Trulicity, I've still periodically gotten sick (extreme bloating, gas, sulfur burps, diarrhea, vomiting, extreme fatigue). I've had my low-functioning gallbladder removed, and I've had an EGD done... and I'm still sick. Nobody can seem to diagnose or fix the digestive issues Trulicity has caused me. I've been off of Trulicity for 10 months. I'm at my wits' end. I wish these awful effects would go away for good."

• Dap...
• Taken for 1 to 6 months
• September 12, 2019

For Type 2 Diabetes "It's been almost 4 weeks now since I've been on the Trulicity 0.75 mg weekly. I did experience some mild nausea and a few headaches, but overall, my experience has been great. My appetite has decreased a lot. I was advised to stay on the 1000 mg of metformin at bedtime by my endocrinologist, which balanced out the constipation and diarrhea. I am, however, gassy... lol... but I can deal with that. I have experienced some weight loss, but I don't know how much. I see it in my clothing, and I feel much lighter. I also have increased energy."

• Nan...
• November 12, 2019

For Type 2 Diabetes "I've been a diabetic for 23 years, and for the last 4 years, I've been all over the charts with my A1C. Dr. prescribed Trulicity last week, I should have read the reviews on this site first. I've been sick the last 4 days! I swear I felt it in my lungs the minute it was injected, then the nausea started. I've been in bed the better part of the last 4 days, but between the cramping, dizziness, diarrhea, headaches, and high blood pressure readings, I've decided it's not working for me. It's not worth the misery. I wanted to give it a chance, but I can't live like this any longer. Any food I put in my stomach feels like a sharp pain, it feels like my insides are turned inside out! I'm 58, and I've quit! Life's too short."

• Jea...
• Taken for less than 1 month
• December 24, 2020

For Type 2 Diabetes "I’m 73 years old, not overweight at all, and have had type two diabetes for the last 10 years. My A1C is up to 8.9, so my doctor started me on Trulicity. To say I am nauseous is an understatement. Headache, abdominal pain, absolutely no appetite. I don’t know how much longer I can tolerate this drug."

• Cin...
• Taken for 1 to 6 months
• October 3, 2020

For Type 2 Diabetes "Trulicity lowered my blood sugars by quite a bit, but it also gave me severe muscle pains, a constant headache, and urinary retention. I tried it several times, but finally had to give it up because I was so miserable."

• Nan...
• October 23, 2016

For Type 2 Diabetes "I was put on Trulicity because I had an allergic reaction to Metformin and Trulicity. I had so much anxiety about taking Trulicity after reading the reviews. I took my first shot on Thursday, and today is Sunday. I have had minimal side effects. I felt a little achy in my shoulders and neck, but it only lasted 2 days. I have not had any of the other side effects. It does curb your appetite, but not to where I cannot eat. When I would wake up in the morning, my readings would range from 140-158, and now they are around 110-115, which is amazing. I would wake up with headaches, and no more headaches. I am very pleased with the results and very thankful for minimal side effects."

• MDa...
• Taken for less than 1 month
• March 5, 2021

For Type 2 Diabetes "I got my first Trulicity injection today, after a failed attempt at doing Metformin. Let me tell you, I think she started me out at too high of a dose! The headaches are horrible, my sugar dropped from 386 (I know that is high) to 108 in just a few hours. I feel weak and tired. But now I'm scared my sugar will bottom out while I'm sleeping."

• Sue...
• Taken for less than 1 month
• October 20, 2018

For Type 2 Diabetes "I told the doctor that I deal with IBS. My stomach is never in very great condition. Just the same, he insisted I take this medication. I told him I had taken Bydureon in the past with no success. The day following the injection, I was suffering from severe stomach pain, vomiting, nausea, headache. I am angry with the drug company, the doctor, the nurse who bit off my head because I refused to continue. It is now 9 days after the injection, and I am still having issues. In my opinion, not a good drug."

• ALO...
• Taken for 6 months to 1 year
• December 15, 2016

For Type 2 Diabetes "I took Trulicity .75 for about 6 months, and it was great! Lowered my A1C from 10 to 7.8! My doctor thought I should try the 1.5 mcg dose to see if I could lower my A1C a little more. I have been on the higher dose for just over 2 months now and am not well. I have headaches 2-3 days a week, diarrhea, and am tired all the time, it seems. I am scheduled to recheck my A1C soon, so I will see if it is worth the 'sick' feelings."

• Txk...
• March 20, 2019

For Type 2 Diabetes "Horrible medicine. Made me feel terrible for two weeks: nauseous, diarrhea, exhaustion, headaches, etc. The drug is truly a poison. I have taken many diabetes drugs, but this one is out of control. Shocking it was approved by the FDA."

• Bel...
• Taken for less than 1 month
• August 28, 2018

For Type 2 Diabetes "Have been taking this drug for three weeks. I must say it has acted as a very good appetite suppressant. Aside from headaches at the start, I have had no side effects and have lost 6 lbs. Eat small amounts and drink plenty of water. Blood sugar readings reduced. So far, I am very pleased with Trulicity. Highly recommend."

• Chu...
• Taken for less than 1 month
• July 23, 2019

For Type 2 Diabetes "I took my first dose on Saturday, July 20, 2019, and immediately I had a headache, nausea, diarrhea, and extreme abdominal pain. It's already my 4th day, and I'm still in extreme pain. I can't eat anything, can't sleep due to the pain, burping sewer smell. I don't recommend this to anyone. I cry in pain. I threw away the other injections. I will never use Trulicity again. I am counting down the days until this medication comes out of my system!"

• Anonymous
• Taken for less than 1 month
• September 27, 2016

For Type 2 Diabetes "I'm only a few days in on my first injection and cannot wait until it's gone through me. I will doubtfully be continuing this medication. I was told about the possible nausea and that it usually presents 3-4 days in. To that, I timed my dose to not present while I was on shift as I work 4 days straight through at a group home. Well, it wasn't 3-4 days in, rather 4 hours in. I am working a shift from hell, very sick. Extreme acid reflux, gas, horrible-smelling burps, extreme nausea, headaches, and dry heaves as I cannot eat. Can't even hold down water. Sure! Losing weight is inevitable if you cannot even hold down water or eat! With that, low numbers are a no-brainer if you're unable to eat!"

• Ove...
• Taken for less than 1 month
• February 21, 2016

For Type 2 Diabetes "Just took my 2nd dose of Trulicity. I am OVER IT!! Aching so bad all over, feeling like I have been hit and run over by a semi. Severe aching in legs and mid-back and arms. Muscle twitching and the scary thing is after about 5 hours of taking the shot...my lips swell and can hardly feel my tongue. My lips and tongue feel swollen and numb. This is scary!! Plus sinuses are swollen, which I DO NOT NEED!! Fight sinus issues on a daily basis, don't need med to make them swell. Pain in the back of neck and head as well. No more of Trulicity for this person. I AM OVER IT."

• Gol...
• Taken for 1 to 6 months
• April 18, 2016

For Type 2 Diabetes "3-month update on Trulicity. When I started, my A1C was at 8 in January. I did have some aches, nausea, heartburn, and headaches. At the end of the three months, I've lost ten pounds, my A1C dropped to 6. From reading other people's experiences and results, I realize that everyone's body and results are different. I wish my A1C was lower, but I will definitely take it. As of right now, I have no longer had nausea or heartburn. I will continue to work on my diet and make better choices, and hopefully next time my A1C will be at a comfortable level."

• Sic...
• November 22, 2015

For Type 2 Diabetes "PART 1: Been on Trulicity for approx. 6 weeks (2 weeks at .5, the rest at 1.5). I FEEL LIKE CRAP. No weight loss, but sugars are running low, sometimes too low (60s). The first 2 weeks were like everyone else: diarrhea, heartburn, etc. BUT THIS WEEK IS THE WORST. I couldn't sleep one night due to the heartburn, I'm constantly nauseous and can't eat. Surprisingly, I've been constipated lately and had to take stool softeners. Yesterday (Saturday) I threw up 4 times!! Reading the other comments did help explain the other effects I also have been experiencing. I am EXTREMELY fatigued ALL the time, I'm already on anti-depressants, but this is actually making symptoms worse than before I was on Trulicity. I have constant headaches....."

• Tra...
• April 3, 2016

For Type 2 Diabetes "My experience has been horrible, headache, constipation, severe heartburn to the point I could not eat for two days after having the injection, extreme body aches for days. Basically, this drug put me in bed for the first two days after having the injection. Today is the third day, I can finally eat and get up, using a cane as the aches in my joints and muscles are so severe. My resting heart rate has also been above 100 since taking the medication. I cannot wait for this to be out of my system!"

• Hea...
• Taken for less than 1 month
• September 25, 2016

For Type 2 Diabetes "First injection on Fri 9-23-16 at lunchtime. Very anxious because of other reports & previous bad reactions to meds. Feet numb for a while, couldn't sit still, blood sugar readings dropped dramatically & ended in the 70s on Fri. Motion sick coming home with a headache. Needed PPI before bed because heartburn - GERD pain was bad. Sat I felt great! 5 lbs weight lost, edema gone, pins & needles in fingers & hands gone! Pins & needles in feet & toes lessened greatly! Chronic anxiety dialed down several levels. I feel 'normal'. I haven't felt this good in decades... I'm 58. Only side effect I could live without is constipation even with fiber, stool softeners, fiber supplement. Now my concern is will ins co approve coverage."

• Sas...
• October 4, 2016

For Type 2 Diabetes "I took my first Trulicity shot on Tuesday, Sept. 27th. I started feeling VERY tired the next day. I work a 12-hour shift, and I could barely make it through the day. Friday evening, I felt very ill. Chills, back pain, and headache. Saturday morning, I was ill. Chills, radiating pain from stomach to back to my head, numbness in my feet, dizziness, confusion, cotton mouth, shakiness, blurry vision, slurred speech, and a huge lump on the right side of my neck. Today is Tuesday, Oct. 4th, and I still feel horrible! I won't take this shot ever again."

• Sic...
• Taken for 6 months to 1 year
• August 21, 2018

For Type 2 Diabetes "Been on this drug for a little over a year. The side effects are awful! Constipation, headaches, sour burps/upset stomach, terrible heartburn, excruciating body aches, mostly in my legs and lower back. I can't manage to sleep more than an hour at a time. Most nights, I can only manage about 4 hours of total sleep because of the pain. My A1C increased and is only getting worse. My thyroid medication stopped working, and my hair is falling out at an alarming rate. I found this forum and realized that so much of my pain and issues could be caused by Trulicity. I never took another dose. It has been a little over a month. I feel so much better, no more pain or stomach issues, and my fasting levels are in the normal range (around 100) for the first time in a year. I don't get another A1C check till next month, but I am confident it will be better. I will never take this drug again!"