Trulicity Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trulicity (dulaglutide)	Ozempic (semaglutide)	Metformin	Enter another drug to compare

Trulicity (dulaglutide)

Ozempic (semaglutide)

Metformin

Prescription only

Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

More about Trulicity (dulaglutide)

More about Ozempic (semaglutide)

More about Metformin

Ratings & Reviews

Trulicity has an average rating of 5.3 out of 10 from a total of 970 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect.

Ozempic has an average rating of 6.7 out of 10 from a total of 1560 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

Metformin has an average rating of 6.8 out of 10 from a total of 656 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 19% reported a negative effect.

View all 970 reviews

View all 1560 reviews

View all 656 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (40.1%)
Diarrhea (24.3%)
Vomiting (18.5%)
Loss of appetite (11.0%)
Upset stomach (8.8%)
Burping (8.6%)
Headaches (7.9%)

View all Trulicity side effects

Nausea (33.3%)
Diarrhea (16.3%)
Constipation (15.6%)
Vomiting (12.4%)
Burping (8.7%)
Upset stomach (7.5%)
Headaches (7.4%)

View all Ozempic side effects

Diarrhea (25.6%)
Nausea (15.4%)
Upset stomach (9.8%)
Stomach pain (4.7%)
Gas (4.6%)
Headaches (4.4%)
Cramps (3.7%)

View all Metformin side effects

Drug Class

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Non-sulfonylureas

Generic Availability

N/A

No lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	2 mL
Strength	0.75 mg/0.5 mL
Per unit^*	$531.93
Cost^*	$1,063.85

View all Trulicity prices

Quantity	1.5 mL
Strength	2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit^*	$716.63
Cost^*	$1,074.94

View all Ozempic prices

Quantity	100 each
Strength	500 mg
Per unit^*	$0.15 - $0.24
Cost^*	$15.37 - $24.08

View all Metformin prices

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Dosage Forms

Subcutaneous solution

Subcutaneous solution

Oral solution
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

120 hours

168 hours

4.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 273 drugs are known to interact with Trulicity:

15 major drug interactions (34 brand and generic names)
256 moderate drug interactions (1452 brand and generic names)
2 minor drug interactions (14 brand and generic names)

A total of 274 drugs are known to interact with Ozempic:

15 major drug interactions (34 brand and generic names)
257 moderate drug interactions (1453 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 378 drugs are known to interact with Metformin:

24 major drug interactions (129 brand and generic names)
344 moderate drug interactions (1797 brand and generic names)
9 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Disease Interactions

First Approval Date

September 18, 2014

N/A

March 03, 1995

WADA Class View classifications

N/A

More Information

Patient Resources

Trulicity uses

Ozempic uses

Metformin uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Trulicity Alternatives Compared

See also:

Jardiance

Xarelto

Ozempic

Rybelsus

Brilinta

Victoza

Saxenda

Empagliflozin

Colchicine

Semaglutide

Further information

Trulicity Alternatives Compared

See also:

Further information

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