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Trulicity Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trulicity (dulaglutide) Ozempic (semaglutide) Rybelsus (semaglutide)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Trulicity (dulaglutide) Ozempic (semaglutide) Rybelsus (semaglutide)
Prescription only

Trulicity mimics the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It lowers blood glucose levels in people with... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

Prescription only

Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more

More about Trulicity (dulaglutide) More about Ozempic (semaglutide) More about Rybelsus (semaglutide)
Ratings & Reviews

Trulicity has an average rating of 5.3 out of 10 from a total of 970 ratings on Drugs.com. 38% of reviewers reported a positive effect, while 40% reported a negative effect.

Ozempic has an average rating of 6.6 out of 10 from a total of 1507 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

Rybelsus has an average rating of 6.4 out of 10 from a total of 283 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 970 reviews

View all 1507 reviews

View all 283 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Trulicity side effects

View all Ozempic side effects

View all Rybelsus side effects
Drug Class
Generic Availability

N/A

No lower cost generic approved

No lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 2 mL
Strength 0.75 mg/0.5 mL
Per unit* $519.94
Cost* $1,039.88

View all Trulicity prices

Quantity 1.5 mL
Strength 2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit* $700.49
Cost* $1,050.73

View all Ozempic prices

Quantity 30 tablet
Strength 3 mg
Per unit* $35.02
Cost* $1,050.73

View all Rybelsus prices

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Dosage Forms
  • Subcutaneous solution
  • Subcutaneous solution
  • Oral tablet
Brand Names

N/A

 Other semaglutide brands include: Rybelsus, Wegovy Other semaglutide brands include: Ozempic, Wegovy
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

120 hours

168 hours

168 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 271 drugs are known to interact with Trulicity:

  • 15 major drug interactions (34 brand and generic names)
  • 254 moderate drug interactions (1444 brand and generic names)
  • 2 minor drug interactions (14 brand and generic names)

A total of 273 drugs are known to interact with Ozempic:

  • 15 major drug interactions (34 brand and generic names)
  • 257 moderate drug interactions (1449 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)

A total of 273 drugs are known to interact with Rybelsus:

  • 15 major drug interactions (34 brand and generic names)
  • 257 moderate drug interactions (1449 brand and generic names)
  • 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Dulaglutide may affect the absorption of other medications that you take by mouth. In some cases... View more
  • Talk to your doctor before using alcohol together with dulaglutide. Alcohol may affect blood... View more
  • Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
  • Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
  • Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
First Approval Date

September 18, 2014

N/A

September 20, 2019
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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