Trulicity and Upset Stomach: What Users Say

• Nay...
• Taken for less than 1 month
• September 22, 2020

For Type 2 Diabetes "I started Trulicity last week. I was a bit nervous before using it because so many people complained of gastric distress. I am very pleased to say I had no problem with the Trulicity. No gastric issues, the injection is painless, and best of all, my blood sugar is actually in a normal range. I'm so glad my physician suggested I try Trulicity."

• Jak...
• June 10, 2020

For Type 2 Diabetes "I was diagnosed with type 1.5 LADA (Latent Autoimmune Diabetes Adult Onset) in November 2019. By December, my endocrinologist prescribed Trulicity along with a Metformin ER pill. This injection was always painful, and the first day or two after the injection, I always felt very nauseous. I've experienced upset stomach and abdominal pain off and on throughout my whole time on these meds. My A1C and other blood work numbers were good, so the doctor decided, with my complaints and good numbers, I went off the Trulicity but continued the Metformin. A week later, I'm in my gastro's office with LLQ pain and am told I have a partial intestinal blockage. It is now June 2020, and I just got out of the hospital with Acute Colitis (forgot to mention that I'm only 20). The biopsy came back showing the cause of my problems as medication. I can't help but blame this on Trulicity and Metformin since I'm not on other medications. I've seen comments about gastro upset but nothing as serious as colitis."

• rag...
• Taken for 1 to 6 months
• May 31, 2020

For Type 2 Diabetes "I took Trulicity for 3 months and it helped me lose weight and lower my A1C. However, the side effects were just too much. I've been off it for 40 days now and I still have very bad side effects including upset stomach, the constant need to belch, throwing up, feeling very cold complete with the shakes, and sweating. I've read the effects last approx a month after discontinuing the drug, but it's been 40 days for me and I'm still feeling the negative effects. Be very careful if you start this drug and have an exit plan ready."

• Pet...
• August 16, 2017

For Type 2 Diabetes "Finally I have found a drug that works for me! In 2 months I have lost 25 lbs. My sugar levels are at an all-time low. Yes, I get some nausea and a little upset stomach but nothing different than before being on other shots/meds. What I have found that works for me is eating a heck of a lot less. If you're not feeling hungry, don't eat unless your sugar is low, of course. Eat very small portions. If you start to feel full, STOP eating! Very small portions and relax. That's my $0.02. This is the best drug I have found since being diabetic but being a realist, drugs react differently to the individual. You won't know till you try."

• daw...
• Taken for 1 to 6 months
• June 18, 2020

For Type 2 Diabetes "I tried Trulicity for 4 months, the stomach upset and sulfur burps were the worst, not to mention the stomach pain, nausea, and increased my acid reflux. Had to take two Protonix and Prilosec a day and still had heartburn from this injection. It's been 3 weeks since I stopped Trulicity. I am doing much better but still have the burps that I never had before this injection. Depending on what I eat, they turn into sulfur burps. Dropped my A1C from 8.8 to 8.4, lost 8 lbs. But not worth the stomach issues."

• Pre...
• Taken for 1 to 6 months
• December 28, 2018

For Type 2 Diabetes "The first dose I did okay with, but each dose after it seems to make me sicker. I usually start feeling bad within 24 hours of taking the shot. It started out as just a stomach ache. Last month, I got so sick. I thought I had food poisoning or the flu. It started with burping up a rotten egg taste. My body felt like I was on fire. I was so weak all I could do was lay my head on the trash can and wait to vomit. Then the diarrhea and stomach cramps came. I spent 4 days throwing up and running to the bathroom. I took my shot yesterday and today, the same exact thing happened. I'm so sick. Burping started around 2 pm, by 5 pm, I knew I was going to vomit. By 6 pm, I was vomiting, and I continue to throw up, and the diarrhea has now come as well. I haven't gotten violently ill every time I take the shot, but after two times, I won't be taking it again. I've never felt so sick in my life. My numbers didn't go down enough to make me want to continue on this medicine."

• Pre...
• Taken for 1 to 6 months
• December 28, 2018

For Type 2 Diabetes "The first dose I did okay with, but each dose after it seems to make me sicker. I usually start feeling bad within 24 hours of taking the shot. It started out as just a stomach ache. Last month, I got so sick. I thought I had food poisoning or the flu. It started with burping up a rotten egg taste. My body felt like I was on fire. I was so weak all I could do was lay my head on the trash can and wait to vomit. Then the diarrhea and stomach cramps came. I spent 4 days throwing up and running to the bathroom. I took my shot yesterday and today, the same exact thing happened. I'm so sick. Burping started around 2 pm, by 5 pm, I knew I was going to vomit. By 6 pm, I was vomiting, and I continue to throw up, and the diarrhea has now come as well. I haven't gotten violently ill every time I take the shot, but after two times, I won't be taking it again. I've never felt so sick in my life. My numbers didn't go down enough to make me want to continue on this medicine."

• Ell...
• Taken for less than 1 month
• April 3, 2020

For Type 2 Diabetes "This is the worst medicine ever, and I’ve taken quite a few. I had to take Trulicity because my insurance won’t cover Victoza without a fight, and this is the second time I’m given low-rated/poorly tolerated medication for this reason. Thanks, Tricare. That same night, I had awful stomach cramping and diarrhea. Then the stomach pain was a little less severe but more persistent. I also suffered fatigue, constipation, bloating, sulfur burps, heartburn, nausea, dizziness, poor sleep, nightmares in addition to the stomach pain. Once it was so bad, it woke me up! I had constipation switched with diarrhea and heartburn for almost 2 weeks, and I stopped the medicine already. It stays in your system for DAYS and still messes with you. It’s awful."

• Ste...
• Taken for less than 1 month
• July 18, 2019

For Type 2 Diabetes "Lucky for us in the UK, meds are all free on the NHS. So, I have now been on Trulicity for 3 weeks. 1st week, awful nausea with tummy ache. Appetite non-existent. 2nd week, similar, but noticed nausea reduced, in fact, it comes and goes in bouts. Not too much bloating, but gassy at times. Bloods down dramatically to 5.5-6.5. Reduced Gliclazide from 2 per day down to half a tablet per day. 3rd week, feeling much better with side effects reduced further again. Weight loss over 3 weeks, average 10 pounds, so very happy. Intend to stay on this for the long term, with exercise, my weight will come off quickly. Very happy with Trulicity, and if you are lucky like me, stay on it. Sorry for all of you who couldn't stick with it."

• Jay...
• Taken for less than 1 month
• May 5, 2019

For Type 2 Diabetes "I started on Trulicity last Monday, and I've been sick as a dog ever since (it's now Saturday night). Within an hour of injection, I was retching at the porcelain altar. Sick to my stomach and stayed in bed the whole next day. Wednesday, I felt good enough to go to the gym and eat lightly, although I still felt slightly nauseous. Wednesday night, I woke up retching again. Sick all day Thursday, and I had a charity dinner to attend that night. Couldn't eat the dinner and went out in the lobby while others dined. Totally miserable! Friday, still sick and weak, foggy brained. Had an appointment with an attorney I was late for because of anal leakage in my khaki pants! Friday night and all day Saturday, I had intense stomach cramps and black liquid diarrhea. Leakage again, had to change pants. Drank half a bottle of Kaopectate, but can't stop diarrhea. I have a concert tomorrow, I don't know if I'll be able to attend."

• Edg...
• May 25, 2020

For Type 2 Diabetes "Been taking Trulicity for 4 years now with no side effect. 3 months ago, I started to feel bloated, stomach upset, keep burping, and nauseated every time I inject Trulicity. I am not sure if I will continue taking it as the side effect is starting to get to me. A1C is 7.8 with Trulicity."

• Cha...
• January 25, 2016

For Type 2 Diabetes "At first, I did have stomach problems, but after 2 weeks, I'm good. I've been on the injection for 3 to 4 months, and I have lost 45 lbs. I feel great, no more high blood pressure, and my A1C was 6.7, now it's 5.3. I love it."

• Mit...
• December 15, 2016

For Type 2 Diabetes "I have been using Trulicity 1.5 for almost one year (started February?). Super easy, nearly painless injections 1x week. Sometimes stomach hurts or a tad bit of decreased appetite. However, nothing serious, nothing at all like the horrid Bydureon. That was THE most awful injections I have ever done and refuse to ever use that again! Trulicity, along with a small amount of Levemir and Metformin, have my blood sugars where they should be. My biggest complaint is the cost. OMG!! The drug manufacturers are gouging us all!!"

• Boo...
• Taken for 1 to 6 months
• February 18, 2017

For Type 2 Diabetes "I have been taking the 1.5 dose now for about a month, it has really gotten my diabetes under control. Yes, I had a little stomach issues (mostly gassy) in the first week or so I used it, but it cleared up. I inject it into my stomach, but I alternate sides every week, so I am not injecting it in the same place all the time. I think this helps. I have experienced a bit of weight loss, about 2 pounds in a month, which is not terrible. But looking at all the other comments in here, I guess it affects people in different ways. My experience has really not been bad at all. I hate giving myself injections, but it far outweighs the high sugar readings. You're supposed to be between 70 and 99, I was 481. I am now down around the 100 mark."

• Grr...
• Taken for 1 to 2 years
• June 26, 2024

For Type 2 Diabetes "To all of those that need to lose those pesky 10 pounds but don't want to put in the work, stop being selfish and think of the health of others for God's sake! Oprah, I'm side-eyeing you. You're in the hospital for 'stomach issues' due to injecting twice, if not more. P.S. This med took my A1c from 10 to 5.2. and I will die with it in my hands."

• JRa...
• Taken for 6 months to 1 year
• December 14, 2018

For Type 2 Diabetes "I have been on a controlled double-blind study for some six months now, not knowing for certain that of two possibilities, I am taking a high dose (1.5) or a lower one (0.75). Because of the sometimes severe side effects, I have to conclude it is the higher dose. I have lost a good deal of weight, and my A1C has dropped from 7.5 or so to 6.7. That's the good news. The bad news is that, like so many other people, I have had really unpleasant side effects, and these seem to be getting worse over time. They include constipation, diarrhea, stomach cramps, awful-tasting belches frequently with a burning acidic taste as well, bad gas, and a more or less constant low-grade nausea malaise."

• Cas...
• Taken for 1 to 6 months
• February 17, 2017

For Type 2 Diabetes "I started a .75 dose in November of 2016. It immediately curbed my appetite and helped me lose 37 lbs by Feb 2017. There is a little stomach discomfort sometimes, but it's not too bad. There is also constipation for about 3 days each week, but I believe it's from the colon not moving anything. The med slows digestion. My experience with the med is positive, much more than with Bydureon. That was a nightmare. I recently went to a low-carb, high-fat diet, and it's working even better now. I hope this helps someone out there. PS, and don't let the doc start you on the higher dose. Ask for samples or rebates because most insurers don't cover it."

• Ink...
• Taken for 1 to 6 months
• April 11, 2021

For Type 2 Diabetes "Taking the lowest dose of Trulicity. Awful stomach issues... gas, bloating, bad taste from burping. I am also very tired, can't do my normal 2 hours a day walking. Been on this for 4 weeks. Told my doctor, and she said to inject every other week. So what will that do? And so low a dosage, then what's the point? Will that reduce anything? She never told me the side effects and instead just that you can lose weight. What's up with this medicine? Lost 13 pounds in 4 weeks from not being able to eat. And this is a good drug?? Let's rethink this."

• Jes...
• June 25, 2017

For Type 2 Diabetes "I have been on this injection for 6 weeks now. The first injection I did in my thigh, and it hurt like hell, the following injections I did in my tummy and didn't feel a thing. I have had an upset tummy, but nothing that I can't put up with, as the benefits have outweighed that. I have a real food addiction, and I have lost interest in food and have to make myself eat, so my blood doesn't go too low. My sugar has dramatically improved, I have more energy, I have lost weight, and suddenly I have motivation back. I would recommend the medication, but it seems it depends on the reaction to your own body if people can use it or not."

• Veg...
• December 6, 2018

For Type 2 Diabetes "12/06/2018 I took my shot on Saturday, Nov 3rd. By Monday, I was bloated, gassy, had severe diarrhea, stomach cramps, and vomiting. I was in the emergency room twice for dehydration in a 2-week time span. I really wanted it to work, but it was not worth the side effects. I have never been so sick in my life. After 28 days of diarrhea and severe stomach cramps, I had to start probiotics as this drug killed all my good bacteria in my gut. It has been about 33 days since I stopped, and I'm still sick. The probiotics have stopped the diarrhea, however, my bowel movements are not back to normal, and I'm still very gassy. Never again will I take this drug, just not worth the side effects, and I don't even know if I will ever be back to normal again. I hope it did NOT do long-term damage to my entire gastrointestinal system."

• Mar...
• Taken for 2 to 5 years
• March 28, 2019

For Type 2 Diabetes "Been on Trulicity for about four years, and for about a year now, I have been having bouts of vomiting, a bloated stomach, constipation, and now acute pancreatitis! Woke up to a bloated, right-side, and painful ache in my middle abdomen area. Felt like my gallbladder pain again, but it has been removed. It was a terrible pain that ran the length across my stomach, and I knew it was my pancreas. After a blood test, it was diagnosed as acute pancreatitis. Doc told me to quit taking Trulicity right away."

• Tam...
• Taken for 1 to 6 months
• March 10, 2023

For Type 2 Diabetes "After being prescribed Trulicity by my diabetes specialist for my diabetes, I took it for a month and a week, which included five injections. However, after a month, I began feeling extremely fatigued, experiencing kaleidoscope vision and an upset stomach with heartburn. I tried contacting my doctor, but they dismissed my concerns, insisting that it couldn't be the Trulicity, claiming it was helpful. Despite this, I received a refill for the second month and took the first injection on July 6, 2022, only to suffer a heart attack. I'm only 46, and I felt fine before I started taking Trulicity. Although my blood sugar levels were high, I had been working on lowering them through a low-carb diet and exercise. I should have trusted my instincts and stopped taking the medication. I regret ever taking Trulicity, and while I'm fortunate to have survived the heart attack, I still feel like I'm struggling every day. My hormones are out of balance, and I firmly believe that Trulicity caused my heart attack."

• Din...
• January 15, 2017

For Type 2 Diabetes "Took this, have been sick all week from one dose, and I will be glad when it wears off, and I will be not taking any more. I had heartburn, an upset stomach, felt so full and sick, especially when I eat. No more of this stuff - one dose enough."

• una...
• February 28, 2016

For Type 2 Diabetes "Second day after first injection, woke up with the worst case of sour stomach I have ever experienced. Burps were out of control, frequent and absolutely disgusting smelling and tasting. Made it to work only to vomit twice in 3 hours... almost messed myself in the process... diarrhea was also in full water effect. Thankfully, I was able to leave early (within 1 hour of second episode). I hope these symptoms decrease dramatically and rapidly. Anyone else experience side effects this severe? I am literally unable to leave my bathroom's side. Cannot even attempt to work or leave the house without fear of needing a new outfit. I took 1, 1.5 injection."

• CeC...
• Taken for 1 to 6 months
• September 12, 2016

For Type 2 Diabetes "My blood sugar levels have definitely come down, from the 250-350 range to the 90-150 range. This med works great for that. However, 5 weeks in and I'm still having side effects that can be hard to deal with. The nausea has lessened, the burping is less, but I still get stomach cramps the first day or two after an injection. I'm also getting muscle weakness, muscle pain, extreme fatigue, joint pain, I'm off-balance, can't concentrate, jittery, woozy, and my peripheral neuropathy seems worse. I definitely eat less. I might be hypersensitive, and every little ache and pain gets blamed on the Trulicity, but since I started it I just don't feel good. I'm not sure if the side effects are worth the good numbers, but I'm hanging in there hoping to adjust!"