Trulicity and Upset Stomach: What Users Say (Page 2)

• Dar...
• September 3, 2020

For Type 2 Diabetes "When I was diagnosed with type 2 diabetes, they immediately put me on Tresiba insulin at 26 units. My A1C was 13 at the time. After 3 months, I got my A1C down to 6.9 but also started gaining weight, as this is a 'side effect' of Tresiba. Been struggling ever since. I have been on Trulicity for about 3 months in addition to the Tresiba. During this time, on the low dose, it did not do anything for suppressing my appetite. It did, however, help lower my blood sugar from the 130 range to 100. 2 weeks ago, we increased to the highest dose, and I have been starving to death. It is 24/7 non-stop. When I eat, I feel like I haven't eaten anything, and I am starving. It really is an unbearable feeling. I am doing my best to not eat much but cannot bear to feel like this all the time. My doctor was shocked and is looking for another alternative. Already tried Ozempic last fall but had severe stomach cramps and a sore throat. Came off of it after 2 months."

• Ter...
• January 19, 2017

For Type 2 Diabetes "I have been on Trulicity (0.75) for about 6 weeks. It has lowered blood sugar about 25 points. I will get A1C in two weeks. The first shot left me with nausea and an upset stomach. That has passed, and now I have no stomach problems. I take the shot at night and am fine by the next morning. It has left me with joint pain in my hands. This pain started the first week, and I still have some joint pain. I keep hoping it will go away. I will see what happens in the next few weeks. I noticed in reviews that other people also had joint pain. Do any of these people have information on how long the pain lasts? In talking with the drug company and pharmacist, no one has any information on this issue. I have lost about 10 pounds."

• Jh2...
• Taken for less than 1 month
• October 27, 2015

For Type 2 Diabetes "I received a sample from my Dr. to try before filling the script. Day I took the injection, I was fine. Day two had mild diarrhea. Day three, severe diarrhea & can't eat. I have literally had 5 crackers & a piece of toast in three days. Vomiting, horrible belching & abdominal pain & still more diarrhea. I am fighting to stay hydrated. I have an upset stomach with Metformin, so I should have known that this would cause problems. I'm convinced that the reason you lose weight with this is because you can't eat at all! I won't be taking a dose this week."

• Kar...
• Taken for less than 1 month
• October 1, 2019

For Type 2 Diabetes "I’m on Week 3 of using Trulicity. I’ve had stomach issues where I can’t poop for 2 days, and then I get a sour stomach followed by horrible diarrhea. I also have horrible heartburn as well. I’m currently looking for things I can do to combat these issues."

• Kkr...
• Taken for less than 1 month
• May 29, 2017

For Type 2 Diabetes "Just started Trulicity last week. I was on Metformin for years and just couldn't take the upset stomach anymore. Also, my numbers would bottom out when I was doing well with my diet and exercise. I was petrified to try Trulicity because of the reviews and the possibility of thyroid cancer. But after a lot of research, I decided to try. I feel great, no horror stories about stomach problems, my numbers are steady and low, and I feel great. My supervisor is going to be so thrilled that I don't have to run home 3 or 4 times a month with terrible stomach problems. I am hoping this continues."

• Kkr...
• Taken for less than 1 month
• May 29, 2017

For Type 2 Diabetes "Just started Trulicity last week. I was on Metformin for years and just couldn't take the upset stomach anymore. Also, my numbers would bottom out when I was doing well with my diet and exercise. I was petrified to try Trulicity because of the reviews and the possibility of thyroid cancer. But after a lot of research, I decided to try. I feel great, no horror stories about stomach problems, my numbers are steady and low, and I feel great. My supervisor is going to be so thrilled that I don't have to run home 3 or 4 times a month with terrible stomach problems. I am hoping this continues."

• Chr...
• Taken for less than 1 month
• August 20, 2018

For Type 2 Diabetes "Taken 3 shots of Trulicity, but that’s it - no more. Feeling ill, almost flu-like. Very tired and zombie-like. Weird stomach and bowel problems, now migraine feeling 1 week after the final shot. Quite angry that this drug is on the market, as testing seems limited, feel like a human guinea pig. Thyroid and pancreatic cancer and pancreatitis high risk. If in any doubt, STOP."

• Dia...
• Taken for less than 1 month
• December 15, 2016

For Type 2 Diabetes "Took the first dose of Trulicity 1.5 Friday 12/09/2016. Saturday was fine. Blood sugar was okay. Taking with 75 units of Lantus in the AM and PM. Sugars are much better (97 this morning). Side effects are real for me though. But they are side effects I have been getting occasionally for the past year, before I started on Trulicity. The major issue for me is stomach cramps, gas (both ends). Sulfur burps are really really bad. Tons of gas. I vomited once and felt much better after doing so. Since I was experiencing these side effects randomly over the past year, I wonder if it's the Lantus - with Trulicity magnifying it. Pure speculation at this point. Dr. for another dose tomorrow. I will take it and see what the next week brings."

• Per...
• May 10, 2016

For Type 2 Diabetes "My doctor put me on this med, and it does work, but DAMN! The fatigue sometimes is almost unbearable. I am lucky that I didn't have any stomach issues, but the fatigue is really getting to me. I had to leave work in the afternoon just so I can lay down. I have my good days. The second day of the shot seems to be the worst. Not sure what I am going to do since it is really helping my A1C, but I still struggle with fatigue, which of course affects everything else, my sex drive is almost gone, and all I want to do is go to sleep."

• Sic...
• Taken for 6 months to 1 year
• August 21, 2018

For Type 2 Diabetes "Been on this drug for a little over a year. The side effects are awful! Constipation, headaches, sour burps/upset stomach, terrible heartburn, excruciating body aches, mostly in my legs and lower back. I can't manage to sleep more than an hour at a time. Most nights, I can only manage about 4 hours of total sleep because of the pain. My A1C increased and is only getting worse. My thyroid medication stopped working, and my hair is falling out at an alarming rate. I found this forum and realized that so much of my pain and issues could be caused by Trulicity. I never took another dose. It has been a little over a month. I feel so much better, no more pain or stomach issues, and my fasting levels are in the normal range (around 100) for the first time in a year. I don't get another A1C check till next month, but I am confident it will be better. I will never take this drug again!"

• Tam...
• Taken for 1 to 6 months
• July 24, 2019

For Type 2 Diabetes "I have uncontrolled type 2 diabetes. I have taken Trulicity for 4 weeks because my Dr. said the symptoms would subside. I have stomach cramps, nausea all day, a headache, and just sorta malaise. I will not inject another shot. I gotta figure something else out."

• der...
• May 31, 2017

For Type 2 Diabetes "I've been a DM Type 2 for 15 years, and in the last 2 years taking Levemir, Novolog, and Janumet. My last A1c was 9.1. I started having abdominal upset and diarrhea from the Metformin in the Janumet, so my doctor took me off of Janumet. He started me on once weekly Trulicity (0.75 mg) 2 weeks ago. Already, I've seen significant changes in my blood sugars: 110-140 (fasting) and 85-170 (post meals). As a result, I'm taking 1/2 the dosage of Levemir and less Novolog prior to meals. I'm hoping to come off insulin. After starting Trulicity, I had some upper abdominal soreness and stomach cramping, but those symptoms have improved. I have not had any diarrhea or nausea. My appetite has decreased because I feel full all the time. So far, so good!"

• Scr...
• Taken for 1 to 6 months
• November 16, 2018

For Type 2 Diabetes "I had every side effect - some worse than others, but the worst of them was the appetite suppression. I ate virtually nothing for four weeks, went through ketosis, and finally into gluconeogenesis. Losing weight as a side effect is no bad thing, but not when it mimics a wasting disease. I have lost, on average, 1 lb in weight a day for the time I was on this drug. Constipation, stomach cramps, nausea, fatigue, and not wanting to eat a thing eventually drove me to seek an alternative. It did bring my blood sugar down, but the side effects have been horrendous. I'm pretty sure a carb-free diet would have had much the same effects."

• Ms ...
• October 11, 2017

For Type 2 Diabetes "I have been on metformin for several years now. I take a 1000 mg pill in the morning and one at night. My A1C was above 7. Six months ago, my doctor wanted me to try Trulicity. I take one shot once a week. It didn't make me nauseous, I didn't have an upset stomach, burping vile odors, no side effects whatsoever. I have noticed that I am dropping weight for no unknown reason, though. I have not dieted or noticed a change in my appetite but have dropped (so far) about 24 lbs. I went yesterday for my 6-month checkup, and my A1C is now down to a 5.8. I am thrilled! Not only have I lost weight without actually trying, but my diabetes is in the normal range. I LOVE TRULICITY!❤️"

• Bri...
• Taken for 1 to 6 months
• January 9, 2020

For Type 2 Diabetes "Have been on Trulicity 0.75 for 5 weeks, no side effects, but did wake up this morning with a stomach ache, but could be anything. Little loss of appetite, lost a little weight. Usually check blood sugars twice a day, but starting new drug, checking it three times until I’m sure how this works. But so far, working good - numbers are down, averages are now 130 at fasting, before lunch 99, and dinner 101. Still take Metformin 500 day and night. A1C was 8.2. Sure A1C numbers will be down next DR. visit. Gave it a 9 because a little too early to give it a 10."

• Anonymous
• Taken for 1 to 6 months
• June 2, 2016

For Type 2 Diabetes "Give Trulicity at least 4 weeks. I, like many others, experienced upset stomach, nausea, and fatigue the first month, where symptoms decreased each week. The nausea was quick and unexpected, and I wanted to throw in the towel. I'm now on week 6 and feel fine most of the time. The fatigue is still there sometimes, but it's been manageable. This has been the best medicine for me by far. I am on the low dose 0.75 and also take metformin 500 mg twice daily. I find the best time to take my shot is at night before I go to bed, and I only take 1-500 mg of metformin the day after the shot, where the side effects were more active. I was on Kombiglyze SR that had 2000 mg of metformin. It did not work for me. My numbers are finally below 120 with Trulicity."

• Pap...
• Taken for less than 1 month
• August 24, 2018

For Type 2 Diabetes "I was put on Trulicity and have taken two doses. Four days after taking the first dose, I developed a sour stomach when I belched, and I belched a lot. Immediately, my stomach started burning, and I had heartburn and a lot of gas in the stomach. Very painful. Then it seemed to move to my intestines, where I felt burning, gas, and eventually diarrhea. This lasted for about five days, then the symptoms subsided. Then I took my second dose, and four days later, all the symptoms came back with a vengeance. Can't live like this. No more for me."

• maw...
• May 23, 2015

For Type 2 Diabetes "Been on for 3 weeks, take shot on Mon. Side effects started on day 3. 2nd week, day 4, this week, day 5. Upset stomach, vomiting, extreme nausea! Nothing helps! Horrible belching and gas! Cannot function on those days. Blood sugars are great! The jury is still out. Do these effects go away after a while?"

• Jus...
• Taken for 6 months to 1 year
• March 7, 2016

For Type 2 Diabetes "Started Trulicity about 8 months ago at .75 mg... In the beginning, very queasy & complete loss of appetite, which was a great thing. Also belching & heartburn/sour stomach. I noticed after about 3 months the effects wore off, so my doctor put me on 1.5 mg 1x per week plus the .75 mg 1x per week. None of the side effects returned... My appetite is back, no queasiness, weight loss stopped, as well as no more sour stomach or belching. Wonder if anyone else has experienced the effects of the medicine wearing off as well. Not sure why I am still on it at this point! Also taking 1000 mg Metformin 2x daily & Invokana."

• Atv...
• November 9, 2016

For Type 2 Diabetes "I took the smaller dosage of 0.75 mg, thank God. The first two days were fine, then the third day everything went south. Blood sugar was 219, the highest I had ever taken. Woke up with an upset stomach, then diarrhea for 6-8 hours, then vomiting for 4-6 hours, then cold chills, a rash that turned to hives from crotch to knees, armpits to elbows, head itched, lips started getting puffy. This was all in 24 hours. It was horrible. Then the next 9 days it took to get completely out of my system. Every day I would have these with less severity. The hives were the only thing that did not recur. At times, I could not stand any clothes on, my body was that sensitive. I found from the doctor at the emergency room that the half-life of the drug was 5 days."

• Ima...
• Taken for 1 to 6 months
• May 22, 2019

For Type 2 Diabetes "Trulicity is the worst medicine for type 2 diabetes. I can't believe the FDA approved this poison. Severe tummy issues, nonstop runs, can't stop them with medicines. I ended up dehydrated and needed fluids. Thyroid cancer is a side effect? WHAT!!! The treatment is worse than the illness. I stopped after it only slightly lowered my A1C from 8.2 to 8.1. Not worth it. I lost weight, but only because I could not eat and vomited or pooped myself to death the whole time taking it."

• Gab...
• Taken for 1 to 6 months
• June 14, 2017

For Type 2 Diabetes "On week 6. Doing well, was pressing too hard and injections hurt but figured it out. Find I have a bit of a stomach ache after the injection, but 1 Gin-Gin ginger candy and it's fine. Also found I can't eat anything with tomato sauce until a few days later or my stomach hurts."

• Ste...
• Taken for 1 to 6 months
• July 11, 2018

For Type 2 Diabetes "I am now on Trulicity for three and a half weeks. I have experienced severe bloating, belching, and flatulence. Also, I have experienced sour stomach and acid reflux. The severe belching and flatulence is enough to keep me awake at night. I've tried Gas-X, does not help, and Rolaids. Has anybody experienced these side effects? On the positive side, my blood sugar has come down the last 75 points to be in the 120 to 130 range, which I have not been able to achieve with Tresiba alone. What I was really wondering, because of the positive effects of lowered blood sugar, will these symptoms subside eventually?"

• Tim...
• October 13, 2017

For Type 2 Diabetes "I started Trulicity a week ago. Side effects haven't been bad. I had stomach issues only when I ate poorly. Lesson learned! I have also dropped about 3 pounds this week. My numbers were normally around 265, now it is under 140. I love this medicine."

• no...
• January 31, 2017

For Type 2 Diabetes "Aside from all of the stomach issues and fatigue, this is now the second time that a box of the pens has been defective. When you contact the company to report it, they all but call you a liar. I will be telling my doctor to find another med. I use other pens and have never had a problem with them. The secondary issue is now I have used pens ahead of time in place of defective ones, and my insurance will not authorize more pens ahead of time. The drug company did agree to do a one-time replacement of the two pens. Getting off now because this tells me I am on my own in the future."