Trulicity and Stomach Pain: What Users Say

• McG...
• January 28, 2019

For Type 2 Diabetes "I am very concerned that this drug is doing more harm than good. Horrible, constantly churning stomach with a very bloated feeling if you remotely consume too much food. I guess it's designed to do that. The worst is the constant belching, a rancid, foul, sulfur taste that can fill a room with a stench. I belched in front of my girlfriend last night on accident (because sometimes it can't be helped) and she actually wondered if I had passed gas... and yes, this is coming out of my mouth. Hard to sleep. A couple of nights this week I awoke with terrible stomach pain. I went to feel my belly and it was as hard as a rock. Passing inconsistent stools and feeling somewhat constipated at times. I thought medication was supposed to help a person feel better, not worse. Sometimes I feel doctors just pass out whatever the drug reps are pushing and do not educate you very well about the drug or side effects. I had asked and he simply said 'mostly a little nausea.' It's more than that."

• Jan...
• September 19, 2020

For Type 2 Diabetes "When I first started Trulicity, I thought it was the end of me. Between the diarrhea, vomiting, headaches, stomach pain, and loss of appetite, I could barely leave my bed. My physician said it would take time to improve, at least 4 to 6 weeks. He moved my dose to 0.75 mg, with no metformin. This drug changed my life."

• Luc...
• Taken for less than 1 month
• October 19, 2019

For Type 2 Diabetes "If you want to feel like walking death, this monstrosity of a 'medication' is for you! I have taken 1 dose of Trulicity, 2 days ago...never again. Sitting on the toilet with explosive diarrhea & projectile vomiting into the tub all night long, my body is killing me, my head is pounding, I'm beyond bloated, the sulfur burps are ridiculous & I feel like I'm getting stabbed in the stomach. It is the same exact thing I went through with Ozempic...don't ever take that stuff either."

• daw...
• Taken for 1 to 6 months
• June 18, 2020

For Type 2 Diabetes "I tried Trulicity for 4 months, the stomach upset and sulfur burps were the worst, not to mention the stomach pain, nausea, and increased my acid reflux. Had to take two Protonix and Prilosec a day and still had heartburn from this injection. It's been 3 weeks since I stopped Trulicity. I am doing much better but still have the burps that I never had before this injection. Depending on what I eat, they turn into sulfur burps. Dropped my A1C from 8.8 to 8.4, lost 8 lbs. But not worth the stomach issues."

• Anonymous
• February 20, 2020

For Type 2 Diabetes "Injected myself for the first time on a Friday night. Feeling very pleased as my levels dropped to 7s. Sunday arvo out and about with hubby. Started getting bad stomach pains. Just before getting into the car, I started projectile vomiting. It wouldn’t stop. Very embarrassed as this was on the footpath and road, and people could see. Pain still very intense in my abdomen. Got home and still projectile vomiting. Doctor prescribed me medicine to stop the vomiting. That worked, but the pain in my abdomen just intensified more. Had foul sulfur burping as well. Later that night was fully constipated, but did finally manage to go. Thought yay finally no more pain. Wrong! 5 minutes later explosive diarrhea nonstop. I’m still in intense pain, still got diarrhea, haven’t been to work all week. Never ever have I felt such intense pain. Doctors daily and still no relief. WORST medication ever! Stay well away from this torture drug!"

• Ell...
• Taken for less than 1 month
• April 3, 2020

For Type 2 Diabetes "This is the worst medicine ever, and I’ve taken quite a few. I had to take Trulicity because my insurance won’t cover Victoza without a fight, and this is the second time I’m given low-rated/poorly tolerated medication for this reason. Thanks, Tricare. That same night, I had awful stomach cramping and diarrhea. Then the stomach pain was a little less severe but more persistent. I also suffered fatigue, constipation, bloating, sulfur burps, heartburn, nausea, dizziness, poor sleep, nightmares in addition to the stomach pain. Once it was so bad, it woke me up! I had constipation switched with diarrhea and heartburn for almost 2 weeks, and I stopped the medicine already. It stays in your system for DAYS and still messes with you. It’s awful."

• Kee...
• Taken for 1 to 6 months
• December 1, 2019

For Type 2 Diabetes "I took this medication for 5 weeks. While informing my doctor of the awful side effects that I was having, he kept assuring me that I would soon feel better. After going to the emergency room on 3 different occasions for severe nausea and stomach pain that had me bedridden for almost 2 weeks straight, come to find out that this medication has given me pancreatic cancer. Do not, I repeat, do not take this medication!"

• Mar...
• Taken for 1 to 6 months
• February 17, 2020

For Type 2 Diabetes "I took Trulicity for 7 weeks, all was well until it was nearly the end of me. I was at work and started feeling stomach pains around 10:00 a.m. By 1:30 p.m., I could no longer stand upright. I ended up in the hospital for a week with severe pancreatitis attributed to Trulicity. I'm now on Metformin, and I cannot control my blood sugars. I am extremely worried and physically very sick. I don't know what to do, I can't bring it below 300s. I am afraid of getting kidney damage."

• goo...
• Taken for less than 1 month
• September 13, 2019

For Type 2 Diabetes "I was given the Trulicity injection because my A1C (sugar levels) was at 8.5%. I decided to take it on a Friday because I knew there might be some side effects. Well, let me tell you. This stuff knocked me hard for the first week. I felt like my entire gastro system was not functioning. My stomach didn't digest normally, I felt sick all the time. The 2nd day I had a lot of gas coming from both ends. I was embarrassed at how much. I felt like I wasn't urinating very much, my bowel movements were almost nonexistent. I had stomach pains that lasted at least 5 days. After 7 days, I am just now starting to feel better. No drug should EVER make you feel the way I felt. Please think twice before taking this drug, it was TOXIC!!! Medication is supposed to make you feel better, not worse. I have serious intestinal and stomach issues, so if you do as well, I would stay clear of this drug. It puts your stomach into a gastroparesis state, AKA slow stomach. NOT a good thing to suffer from."

• Mot...
• Taken for less than 1 month
• March 7, 2020

For Type 2 Diabetes "I just injected Trulicity for the second time, and I noticed that my numbers first thing in the morning are averaging 160 - 180, where before taking Trulicity, my numbers averaged 130 - 150. I have stomach pain off and on, feel sick to my stomach a lot, and my right side under my ribs, I feel pain. I will try and do this for 1 month and see if this drug improves my numbers, but right now, the drug sucks. I am taking Glipizide in the morning and evening, but numbers have not improved."

• Sav...
• May 21, 2023

For Type 2 Diabetes "My husband was in a bad car accident, and the pain and stress caused his blood sugar to be very high. After 3 months, he was prescribed Trulicity to get it to come down. Well, he had stomach pains, nausea, vomiting, and decreased appetite, and he lost 30 pounds in 2 months. He was NOT OBESE! Now he is weak and still can’t eat, even after quitting it 3 weeks ago."

• Spr...
• April 30, 2020

For Type 2 Diabetes "This is my 2nd month on Trulicity. First month, I had the 1.75 and had too many side effects: nausea, stomach pain, loss of appetite, and some ankle swelling. Called doctor, and he reduced dosage to the .75, and so far, so good. I can’t take this med with Metformin, though, because I get a worse effect when I take both together."

• Tex...
• Taken for 1 to 6 months
• March 20, 2016

For Type 2 Diabetes "I am pre-diabetic or A1C over 5.9. Last year, my doctor prescribed Trulicity to help with weight loss, as I am taking metformin as well. After my 6 weeks of injections, I had to stop due to stomach pain and uncontrollable belching. I mean, belching that could make a maggot gag! But recently, my A1C hit 6.1, and it was during the tasty holidays that it happened. So, in February, we started with the 0.75 injections, and I have learned if you reduce your portion sizes and eat less greasy fried food, the belching stopped, and so did any stomach side effects. With Trulicity injections, I feel full all day and just snack on fruit and smaller meals. I have lost over 15 lbs since February, it is now late March. I will post an A1C update in the future."

• Mrs...
• Taken for 1 to 6 months
• July 24, 2020

For Type 2 Diabetes "Been on Trulicity for a few months for pre-diabetes, ended up in the hospital with severe vomiting, diarrhea, and stomach pains. No one figured Trulicity, now, 3 weeks later, same episodes. I am done with this!!!"

• Sma...
• Taken for 1 to 2 years
• December 28, 2019

For Type 2 Diabetes "Oh my goodness... this drug is the strangest thing. Initially was constipated with severe distension of my stomach. I have Crohn’s disease also, but that’s been controlled well. After getting to a higher dose, lost about 14 lbs. Side effects were bearable, and HbA1c went to normal ranges. Decided to try and come off the drug after a year... big mistake. My BGL levels went up, diabetic symptoms returned, went back on Trulicity, and I’ve had severe bowel urgency and accidents in public, sulfur burps (Pepto-Bismol cures that), general feeling of unwell, and stomach pain (it’s just like having out-of-control Crohn’s disease, but I know it’s not that). I’m taking myself off it as can’t handle it anymore."

• Bec...
• Taken for 1 to 6 months
• January 23, 2017

For Type 2 Diabetes "This was my 4th week taking Trulicity .75. The 1st two weeks went okay, the 3rd week I started having severe pains in my stomach, severe nausea, hives, diarrhea. The 4th week was the same but worse, I broke out in hives from my head to my feet, had welts all over me. I just got back from the hospital last night because of it. And it's still doing the same thing the next morning, I wake up with severe stomach pains, nausea, I belch and it tastes like rotten eggs, diarrhea, and the itching, hives everywhere! Ended up having to take prednisone and Benadryl for the hives rash, Zofran and acid reducers for the sickness and vomiting. It makes food lay in my stomach and doesn't let it digest. Please do research on this medicine if it is offered."

• Mik...
• November 16, 2018

For Type 2 Diabetes "OMG... I thought it was just me, but I have to agree with many others. Although it has lowered my A1C, the side effects are horrendous. The worst stomach pains and gas cramps with diarrhea for 3 days after I take my injections on Mondays (1 per week). And thank goodness for that. I couldn't do two injections in a week, I'm already feeling so down and out and lousy for 3 days. It takes me those other 4 just to recover. No pain, no gain. Well, not my idea of losing weight and sitting on the toilet for the next 2 days with stomach pains and gas pains and cramps. Not what I had in mind. I never knew my stomach made that many sounds. Not to mention the worst heartburn I've ever had in my life, like burning my esophagus right out of my throat. I'm calling my doctor. I might not have lost weight on Metformin, that was fine to me. The nausea from Victoza was bad, it's not even close to how Trulicity makes me feel. Those of you with good results and no side effects, God bless you. I just can't say the same."

• Sue...
• Taken for less than 1 month
• October 20, 2018

For Type 2 Diabetes "I told the doctor that I deal with IBS. My stomach is never in very great condition. Just the same, he insisted I take this medication. I told him I had taken Bydureon in the past with no success. The day following the injection, I was suffering from severe stomach pain, vomiting, nausea, headache. I am angry with the drug company, the doctor, the nurse who bit off my head because I refused to continue. It is now 9 days after the injection, and I am still having issues. In my opinion, not a good drug."

• Evi...
• Taken for less than 1 month
• April 15, 2019

For Type 2 Diabetes "I took my first injection of Trulicity on a Thursday. On Sunday morning, I woke up and I had stomach pain, diarrhea, wanted to vomit, and felt horrible. I thought I was sick. After 3 days, I was okay. Then my second injection was done on the next Thursday, and I woke up again on Sunday with stomach pain and diarrhea. I can't use it anymore. My blood sugar is very good, but I can't live like that."

• Aci...
• Taken for 1 to 6 months
• January 5, 2019

For Type 2 Diabetes "I've been taking Trulicity for about 2 months. Nausea, horrible acid reflux, stomach pain and bloating, constipation. I'm scared to eat too much, so I suppose I've lost some weight, but at what price? I'm stopping this poison. I can feel fine and literally in 3 minutes, then be vomiting water."

• Per...
• Taken for 6 months to 1 year
• August 22, 2016

For Type 2 Diabetes "Been on Trulicity over 8 months, 6 or so months ago, thought I had pancreatitis, stomach pain so bad, sulfur burps, stomach swollen with gas, nausea, going through tests to find out what's wrong, then back pain that I've never had before, so severe. Already need hips and knees replaced, but knee pain got worse, nausea every day and night, sipping ginger ale just to survive, can't eat, except for cheese nips...not till today did I realize all this may be caused by Trulicity!! Thought I was dying!! Ugh, happy to have found this site."

• miz...
• Taken for 1 to 2 years
• June 7, 2019

For Type 2 Diabetes "I have been on Trulicity for about 13 months. At first, I experienced nausea and loss of appetite. I lost 13 pounds within about the first 6 weeks! I took nausea medicine to help me get through the nausea symptoms. But it did help my A1C drop from 9.3 to 6.6. After several months, my symptoms subsided and I seemed to be on an even keel. My appetite returned and I gained weight back. All of a sudden, for the last 5 weeks, I have been sick as a dog! The nausea has returned, I have indigestion and belching like never before, and stomach pain. I am miserable. I am constipated, I am fatigued, and my kidney specialist tells me the Trulicity is causing my problems. I took my last injection 2 days ago, and the rest of it is going in the trash!!! No more for me."

• Nev...
• Taken for 1 to 6 months
• June 28, 2018

For Type 2 Diabetes "The first week after the shot, I felt exhausted and had no appetite whatsoever. I could only eat a few bites of each meal. The second week, I felt totally normal. Third week, less than 6 hours after taking the dose, I was vomiting and had severe stomach pains and diarrhea. I was so sick that I had to go to the emergency room. The remainder of that week, I would have terrible diarrhea after eating any carbs or fatty foods. The doctor told me to try it one more time. I waited 2 weeks to try it again because I was honestly mortified from the time before. I tried it once more and had severe stomach pains and bloating all that day. That night, I began vomiting and felt like I was going to pass out. It began to be so severe that I had to be hospitalized again. I will never take this medication again. I felt 10x worse than I did when I had the flu. I’m only 21 years old, and usually, my body is not sensitive to medications."

• Mon...
• Taken for 1 to 6 months
• July 4, 2019

For Type 2 Diabetes "The first week the nausea was awful, and I also had stomach pains. Each week the nausea, present on days 2-3, became less. My HbA1c has dropped from the 8’s to 5.9, and I have lost approx 7 kilos. I will continue on this medication, can’t ignore these good results."

• Anonymous
• Taken for less than 1 month
• September 28, 2019

For Type 2 Diabetes "This medication, Trulicity, is good to lower your A1C, but not worth it with the side effects. The constant sulfa burps, bloating, stomach pain, looking like I’m 9 months pregnant, waking up aspirating is the worst part. I developed gastroparesis with other injection medications like Trulicity and was told Trulicity should be mild compared to Victoza and meds similar. But by far, Trulicity is a lot worse. I would rather use insulin and feel better than be on a medication where I feel miserable and can only eat jello or saltine crackers."