Comparing Estradiol / Norethindrone vs Prempro
| Estradiol / norethindrone | Prempro (conjugated estrogens / medroxyprogesterone) |
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| Estradiol / norethindrone | Prempro (conjugated estrogens / medroxyprogesterone) |
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Prescription only
Prescribed for Postmenopausal Symptoms, Atrophic Vaginitis, Atrophic Urethritis, Hypoestrogenism. Estradiol / norethindrone may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Postmenopausal Symptoms, Atrophic Vaginitis, Osteoporosis, Atrophic Urethritis, Oophorectomy, Primary Ovarian Failure. Prempro may also be used for purposes not listed in this medication guide. View more |
Related suggestions Atrophic Vaginitis
Atrophic Urethritis
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| More about Estradiol / norethindrone | More about Prempro (conjugated estrogens / medroxyprogesterone) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Estradiol / norethindrone has an average rating of 6.5 out of 10 from a total of 97 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 27% reported a negative effect. |
Prempro has an average rating of 6.9 out of 10 from a total of 67 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
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View all Prempro side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Estradiol / norethindrone prices |
View all Prempro prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Activella, Amabelz, CombiPatch, Ena, Etyqa, Lopreeza, Mimvey, Mimvey Lo | Other conjugated estrogens / medroxyprogesterone brands include: Premphase, Premphase 14/14 | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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14 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 439 drugs are known to interact with Estradiol / norethindrone:
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A total of 315 drugs are known to interact with Prempro:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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November 18, 1998 |
November 17, 1995 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
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N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.