Prempro and Cramps: What Users Say

• FLy...
• November 8, 2009

For Postmenopausal Symptoms "Periods recommenced on using this, also got menstrual cramps (which I had before so no huge deal). Lost all sweating symptoms and skin became less dry, although skin is itchy. Other than this I have had no other bad side effects; have been on this medicine now for approximately 6 months."

• Sam...
• Taken for 1 to 6 months
• February 8, 2021

For Postmenopausal Symptoms "After having a complete hysterectomy, I started hot flashes that same day of the surgery. At my 2-week post-op, I was a mess, wasn’t sleeping, hot flashes, crazy emotionally. My doctor started me on Prempro. Sticker shock on the cost, $206 for a 1-month supply! After a month, I felt great, sleeping and less emotional. A few months in, I started experiencing migraines and awful cramps in my legs. I didn’t want to go off Prempro, but the migraines were happening so often that I couldn’t get my work done, so I had to discontinue it after 6 months. I’ve since switched to a doctor that uses a compounding pharmacy and am trying to find the right combination of hormones."

• cbe...
• April 5, 2012

For Oophorectomy "I am 22 and underwent oophorectomy surgery following 2 massive ovarian cysts on each ovary. Right out of surgery, I was prescribed Prempro and had to take it. I experienced hot flashes for the first few days. The doctor told me that if I felt bloated, I could skip a week and I would have a small period, which I have done. I had cramps and sporadic bleeding, but the bloating never went away. I have gained a lot of weight that has been really hard to lose, and I have been on this medicine for only 3 months. I also have really bad acne all over my face that I haven't had since junior high. Once I go back to the doctors, I will be asking to try another hormone replacement therapy."

• Sun...
• Taken for less than 1 month
• February 21, 2021

"I enjoyed reading all the comments. I literally took my first pill last night. I will be 50 in August, and for the last 2 years, I’ve had hot flashes, day and night, can’t sleep, and terrible leg cramps where I would need to get up in the middle of the night and walk. My doctor suggested I take it at night at the same time every day! She wants to see me in 4 weeks because my blood pressure was a bit high at my appointment. Never had an issue with my pressure. I think I was just nervous. I hope my experience will be a good one!"

• Anonymous
• Taken for 1 to 6 months
• January 13, 2022

For Postmenopausal Symptoms "Doctor had me on Premarin for a year, worked great. Doctor then switched me to Prempro. Only took for a month and a half, was having leg cramps and a period after no period for 5 years. I’ll try a supplement instead."

• Kri...
• August 9, 2016

For Postmenopausal Symptoms "I had a heavy, painful period and was clotty. Also, breast tenderness. I needed to stop this medicine after being on it just one month."