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Prempro and Bloating: What Users Say

Bloating: mentioned by 7 users (10.4%)

Based on user experiences from 67 Prempro reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 26.9%
night sweats 11.9%
weight gain 11.9%
bloating 10.4%
cramps 9.0%
hair loss 7.5%
sore breasts 7.5%
depression 6.0%
moody 6.0%
acne 4.5%

Reviews for Prempro

Commonly mentioned side effects
  • Jul...
  • January 28, 2020

"I’m 54 and started taking Prempro for 3 months, and hot flashes and night sweats are gone. I’m not as irritable as I was, and not as tired. I am very active-gym, running, biking, etc.-so I think that helps with meditation. The only thing I have noticed is some mild bloating. It’s not so bad that I will stop using it. Hope this was helpful."

9 / 10
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44 Report
  • Vik...
  • Taken for less than 1 month
  • November 18, 2019

For Postmenopausal Symptoms "I'm 44 years old. I haven't had a period in over 4 years. My hormones were out of whack. My symptoms I was having were hair loss, hot flashes, and I was mean and hateful. My doctor put me on Prempro. I've been on it for a month now... Hot flashes are gone. My hair stopped falling out. My breasts didn't get too bad tender, but they did get fuller. My mood has not changed, I'm still moody. I already had acid reflux, and Prempro made it even worse! My feet feel a little swollen, or at least my shoes feel tighter. And I do feel a little bloated. I've decided to stop taking Prempro. I would rather deal with the hot flashes and hair loss than the acid reflux flare-ups."

8 / 10
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28 Report
  • Lis...
  • October 29, 2013

"I started on Prempro on September 2, 2013, for my night sweats, hot flashes, and mood swings. I was on it for almost two months. The first month was fine, but during the second month, I developed way too many severe side effects. I had: swelling of hands and ankles, breast enlargement and pain, severe bloating, vaginal irritation, acne, my mood swings worsened, and I gained a lot of weight. The night sweats and the hot flashes got better, but the side effects were much worse than the night sweats and hot flashes. I started on Healthy Woman Soy Menopause Supplement, and it took care of the night sweats and hot flashes without all of the other side effects. This drug is definitely not for everybody, and my advice would be to listen to your body!"

1 / 10
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48 Report
  • Kat...
  • Taken for 1 to 6 months
  • May 14, 2022

For Postmenopausal Symptoms "I was lucky to not experience menopause until 55, but moderate hot flashes became annoying, so the doctor prescribed low-dose Prempro. At first, everything seemed fine, but after a couple of months, acne and weight gain ruined it for me. I was seriously waking up every couple of days with new pimples, and I've had good skin my whole life. Weight gain and bloating also started, and I've been thin my entire life. So no way I'm living with blotchy, bad skin and a pot belly to solve a few hot flashes."

3 / 10
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12 Report
  • Mcm...
  • Taken for less than 1 month
  • November 19, 2019

For Postmenopausal Symptoms "So I was taking Remifemin, which wasn’t working for me, so I asked my doctor about HRT. I was having severe hot flashes at night, where I was soaking wet, and hot flashes maybe 3 to 4 an hour at 48 years old, and I’ve stopped my period pretty much eight months ago. I am on my fourth day and really haven’t seen a difference in hot flashes and night sweats yet, still bloated and very sensitive, like crying at really stupid stuff... lol. I’m looking forward to seeing how this medication works, but it is awfully expensive, but thank God I can somewhat afford it."

6 / 10
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21 Report

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  • Deb...
  • Taken for less than 1 month
  • September 5, 2019

For Postmenopausal Symptoms "Pros: Better mood, sexual functioning back to normal (great!). Cons: Every day terrible bloating, gas, and constipation. On the third week, sudden terrible water retention in legs made walking uncomfortable for me (I'm normally very athletic). I'm not sure if the severe migraine I had 10 days ago was the Prempro or not, but it's suspicious since I had to go in for injections on emergency for the first time from my headache specialist. I plan on NOT taking it in the morning and calling my doctor about the water retention. (I already called regarding the other side effects, but the edema occurred after that phone call today). Anyway, I was going to just ask for either a lower dose or an option a friend recommended (Bijuva). But now, I just want to switch meds altogether. This amount of edema just won't cut it for me!"

3 / 10
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13 Report
  • cbe...
  • April 5, 2012

For Oophorectomy "I am 22 and underwent oophorectomy surgery following 2 massive ovarian cysts on each ovary. Right out of surgery, I was prescribed Prempro and had to take it. I experienced hot flashes for the first few days. The doctor told me that if I felt bloated, I could skip a week and I would have a small period, which I have done. I had cramps and sporadic bleeding, but the bloating never went away. I have gained a lot of weight that has been really hard to lose, and I have been on this medicine for only 3 months. I also have really bad acne all over my face that I haven't had since junior high. Once I go back to the doctors, I will be asking to try another hormone replacement therapy."

3 / 10
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24 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.