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Prempro and Sore Breasts: What Users Say

Sore breasts: mentioned by 5 users (7.5%)

Based on user experiences from 67 Prempro reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 26.9%
night sweats 11.9%
weight gain 11.9%
bloating 10.4%
cramps 9.0%
hair loss 7.5%
sore breasts 7.5%
depression 6.0%
moody 6.0%
acne 4.5%

Reviews for Prempro

  • EBR...
  • Taken for 1 to 6 months
  • March 5, 2019

For Postmenopausal Symptoms "I hit menopause at 43 and didn’t know what to do. I originally started taking a vitamin pack designed for menopause but the price was a bit outrageous. When I saw my doc, she suggested taking a low dose (1.5) of Prempro. Wow! I liked the vitamins, but I really love what Prempro gave me. No hot flashes anymore! Restful sleep! I have also noted a decrease in my appetite, which for a while was the same as a teenage boy! Overall, I’m very happy after being very worried about taking an HRT. The only side effect I’ve experienced in the negative is my breasts are a bit more tender than normal. Not sore so much as tender. Good luck to all. I found this very helpful."

9 / 10
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113 Report
  • Vik...
  • Taken for less than 1 month
  • November 18, 2019

For Postmenopausal Symptoms "I'm 44 years old. I haven't had a period in over 4 years. My hormones were out of whack. My symptoms I was having were hair loss, hot flashes, and I was mean and hateful. My doctor put me on Prempro. I've been on it for a month now... Hot flashes are gone. My hair stopped falling out. My breasts didn't get too bad tender, but they did get fuller. My mood has not changed, I'm still moody. I already had acid reflux, and Prempro made it even worse! My feet feel a little swollen, or at least my shoes feel tighter. And I do feel a little bloated. I've decided to stop taking Prempro. I would rather deal with the hot flashes and hair loss than the acid reflux flare-ups."

8 / 10
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28 Report
  • Anonymous
  • March 17, 2011

For Postmenopausal Symptoms "I have been using this medicine for 1 year for hot flashes, and now I have developed sore breasts. Otherwise, this medicine is great, no more hot flashes. Have to use vaginal cream also."

9 / 10
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40 Report
  • Car...
  • Taken for 1 to 6 months
  • October 16, 2019

For Postmenopausal Symptoms "I've been taking Prempro for 2 months, no more hot flashes, and I'm sleeping now. The only con is I've been bleeding lightly for 2 to three weeks, and my breast hurts. I think I'm done."

6 / 10
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13 Report
  • Kri...
  • August 9, 2016

For Postmenopausal Symptoms "I had a heavy, painful period and was clotty. Also, breast tenderness. I needed to stop this medicine after being on it just one month."

2 / 10
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9 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.