Prempro and Weight Gain: What Users Say

• Rly...
• Taken for less than 1 month
• March 16, 2021

For Postmenopausal Symptoms "I was feeling stuck in perpetual PMS. I was really moody, starving all the time, tired and unmotivated, and gaining weight. Hot flashes were about to finish me off. My doctor gave me a prescription for Prempro. I noticed a difference in 2 days! I am so much less moody, have more motivation, and way less hungry. Tonight will be my 4th dose, and I honestly cannot wait to see how I feel after a week."

• Hop...
• Taken for 2 to 5 years
• September 18, 2018

For Postmenopausal Symptoms "I took Prempro for about four and a half years. I started at the age of 57, and it did help with some of my problems. But I ended up gaining 50 lbs and also developed breast cancer at the age of 62. I have three other sisters, and none of them or any other women in our family have had breast cancer. Think before you take this pill. I am no longer on Prempro, and I have all my menopausal symptoms back in full force."

• Lis...
• October 29, 2013

"I started on Prempro on September 2, 2013, for my night sweats, hot flashes, and mood swings. I was on it for almost two months. The first month was fine, but during the second month, I developed way too many severe side effects. I had: swelling of hands and ankles, breast enlargement and pain, severe bloating, vaginal irritation, acne, my mood swings worsened, and I gained a lot of weight. The night sweats and the hot flashes got better, but the side effects were much worse than the night sweats and hot flashes. I started on Healthy Woman Soy Menopause Supplement, and it took care of the night sweats and hot flashes without all of the other side effects. This drug is definitely not for everybody, and my advice would be to listen to your body!"

• Kat...
• Taken for 1 to 6 months
• May 14, 2022

For Postmenopausal Symptoms "I was lucky to not experience menopause until 55, but moderate hot flashes became annoying, so the doctor prescribed low-dose Prempro. At first, everything seemed fine, but after a couple of months, acne and weight gain ruined it for me. I was seriously waking up every couple of days with new pimples, and I've had good skin my whole life. Weight gain and bloating also started, and I've been thin my entire life. So no way I'm living with blotchy, bad skin and a pot belly to solve a few hot flashes."

• Ter...
• Taken for less than 1 month
• July 10, 2024

For Postmenopausal Symptoms "I've been taking Prempro for the past month. The first week, my hot flashes got worse, but by week 2, they started to cool off. So far, I like what I'm feeling, but I can't sleep without my fan. I think I'm gaining weight. Today I got my second refill, and I started searching for more info. To be honest, what I read really scared me and made me rethink if I should continue taking it."

• cbe...
• April 5, 2012

For Oophorectomy "I am 22 and underwent oophorectomy surgery following 2 massive ovarian cysts on each ovary. Right out of surgery, I was prescribed Prempro and had to take it. I experienced hot flashes for the first few days. The doctor told me that if I felt bloated, I could skip a week and I would have a small period, which I have done. I had cramps and sporadic bleeding, but the bloating never went away. I have gained a lot of weight that has been really hard to lose, and I have been on this medicine for only 3 months. I also have really bad acne all over my face that I haven't had since junior high. Once I go back to the doctors, I will be asking to try another hormone replacement therapy."

• Anonymous
• June 1, 2017

For Postmenopausal Symptoms "I had been on Enjuvia (plus a progesterone supplement) for 3+ years, and they worked fantastic from day one! Unfortunately, they have stopped making it for reasons I can't find. I was put on Divagel, and I gained 15 pounds in 3 weeks, plus the leg (including my foot) I put it on swelled up like a balloon, among other side effects. I have been on Prempro for 6 days now, and my hot flashes/night sweats are worse than ever, but all my other 'problems' seem to be okay. The doctor's office said to give it a month, wish me luck!"

• Mag...
• Taken for 10 years or more
• April 5, 2025

For Postmenopausal Symptoms "I feel extremely fortunate to have had a female MD at the time I hit menopause. I was 50, and my husband died around the same time menopause hit. My MD prescribed Prempro 0.3/1.5, and I believe this has kept my body healthy for the past 19 years, and yes, I am still taking Prempro today. I still maintain a healthy sex life (with my long-term partner), my bone density is good, and my overall health is very good. My gynecologist refused to prescribe this many years ago, but my PCP continues to prescribe this for me. All my friends are just now learning about the health benefits of HRT, for many, it is too late, and some prefer to use bioidentical or natural hormones. Prempro helped me through my grief, it helped with hot flashes and night sweats, and helped prevent weight gain. It is very expensive, hopefully a generic someday soon! I will reach out to Pfizer to see about some sort of discount."