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Estradiol / norethindrone and Bloating: What Users Say

Brand names: CombiPatch, Activella, Amabelz, Mimvey, Ena, Lopreeza, Etyqa, Mimvey Lo

Bloating: mentioned by 6 users (6.2%)

Based on user experiences from 97 Estradiol / norethindrone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 17.5%
bleeding 12.4%
anxiety 10.3%
insomnia 9.3%
cramps 8.2%
night sweats 8.2%
bloating 6.2%
mood swings 6.2%
hair loss 5.2%
spotting 5.2%

Reviews for Estradiol / norethindrone

Commonly mentioned side effects
  • gml...
  • Taken for 1 to 6 months
  • October 20, 2024

Estradiol / norethindrone for Postmenopausal Symptoms "I have been on the lower dose CombiPatch for over 5 months, and it has been a lifesaver. My hot flashes disappeared within a week of starting, I consistently sleep through the night, sex is great (my natural lubrication is back and orgasms are easy again) - it really has changed my life. I'm almost 58 and just stopped having periods last year - I was in perimenopause for a LONG time. I can't believe I lived with such debilitating symptoms for so many years. I had forgotten what it was like to wear sweaters and sleep under cozy blankets - I was just so hot all the time! Now I feel like myself again, and it's amazing. I've had no breakthrough bleeding, just a bit more bloating than usual when I first started the patch (that's pretty much gone away now). I've never had a patch fall off, and I swim and soak in the bathtub regularly. Sometimes the sticky residue left when I remove a patch is a little challenging to get off my skin, but I found rubbing alcohol works like a charm."

10 / 10
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7 Report
  • JMa...
  • Taken for 1 to 6 months
  • December 14, 2018

Estradiol / norethindrone for Postmenopausal Symptoms "I was diagnosed with sudden early menopause. Severe migraines (worse than I ever had), anxiety and panic attacks, insomnia (barely sleeping), depression, and night sweats. I really started feeling 90% better within a couple of weeks. I’m sleeping. Anxiety is minimal, and I’m sleeping again. Minimal side effects, but I’ve had bloating and bad indigestion."

8 / 10
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27 Report
  • Nic...
  • Taken for less than 1 month
  • September 12, 2021

Estradiol / norethindrone for Postmenopausal Symptoms "I have been going through full-blown menopause for 8 years, plus I was in peri-menopause for 3 years prior to that. I have not taken hormone replacement therapy up to this point. However, after my skin, hair, and nails got even drier, no sex drive, and not being able to have intercourse with my husband for about 3 years because the pain was too unbearable, I decided to try HRT. My doctor put me on the CombiPatch. At first, I did not have any side effects, but I have had constant bleeding for the last 2 weeks with mild cramping and bloating. I found myself barely being able to hold my eyes open around 4 pm every day and was having to sleep. This was my first month being on it, and I have one patch left. At the end of the 7th patch, I took it off and did not put my last patch on. It has been 3 days now with no patch, and I am still bleeding, cramping, and bloating. This has been horrible. I will deal with the hot flashes. I have dealt with them for 11 years...better than HRT."

1 / 10
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16 Report
  • Bet...
  • Taken for 1 to 6 months
  • May 15, 2022

For Postmenopausal Symptoms "I am 57, postmenopausal. Originally prescribed Bijuva 2 years ago for severe hot flashes, palpitations. It worked wonders! Although insurance would not cover, I used a coupon. Two months ago, my large chain pharmacy would not honor the coupon, so my MD ordered Activella/Mimvey 1 mg estradiol, 0.5 mg norethindrone acetate. I was given the generic. Wow, what a difference-enlarged, tender breasts, bloating, discharge (not bloody), overall feeling yuck. Bijuva uses progesterone while Activella et al. uses norethindrone acetate. I'm very surprised and upset with the difference in my overall well-being."

4 / 10
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1 Report
  • AMT...
  • Taken for less than 1 month
  • April 2, 2023

"I am 43 years old. I started using the patches a week ago. I haven’t had a period in the past 6 months and have been feeling menopausal symptoms for over a year. My doctor and partner suggested that I try the treatment. They had concerns because of my age. I started bleeding less than 24 hours after my first patch, and my mood is very bad. I can’t hear any noise. I had terrible cramps and bloating. I have always suffered from cramping and heavy bleeding. I truly hope this is just passing bleeding and I won’t have to deal with it."

5 / 10
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0 Report
  • Anonymous
  • Taken for 1 to 6 months
  • October 27, 2015

For Postmenopausal Symptoms "Experienced mood swings, menstrual cycle of 6 days, bloating, sore breasts, backache, cramping, etc... felt horrible, tired, run down."

1 / 10
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2 Report

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