Estradiol / Norethindrone Dosage
Medically reviewed by Drugs.com. Last updated on Mar 18, 2022.
Applies to the following strengths: 1 mg-0.5 mg; 0.05 mg-0.14 mg/24 hours; 0.05 mg-0.25 mg/24 hours; 0.5 mg-0.1 mg
Usual Adult Dose for:
- Atrophic Urethritis
- Atrophic Vaginitis
- Hypoestrogenism
- Postmenopausal Symptoms
- Prevention of Osteoporosis
Additional dosage information:
Usual Adult Dose for Atrophic Urethritis
1 tablet orally once a day
Comments:
- Use at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Re-evaluate periodically to determine if treatment is still necessary.
- Only the estradiol 1 mg/norethindrone 0.5 mg strength is recommended for vulvar and vaginal atrophy treatment.
Uses:
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Usual Adult Dose for Atrophic Vaginitis
1 tablet orally once a day
Comments:
- Use at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Re-evaluate periodically to determine if treatment is still necessary.
- Only the estradiol 1 mg/norethindrone 0.5 mg strength is recommended for vulvar and vaginal atrophy treatment.
Uses:
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Usual Adult Dose for Hypoestrogenism
1 tablet orally once a day
Comments:
- Use at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Re-evaluate periodically to determine if treatment is still necessary.
- Only the estradiol 1 mg/norethindrone 0.5 mg strength is recommended for vulvar and vaginal atrophy treatment.
Uses:
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Usual Adult Dose for Postmenopausal Symptoms
1 tablet orally once a day
Comments:
- Use at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Re-evaluate periodically to determine if treatment is still necessary.
- Only the estradiol 1 mg/norethindrone 0.5 mg strength is recommended for vulvar and vaginal atrophy treatment.
Uses:
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Usual Adult Dose for Prevention of Osteoporosis
1 tablet orally once a day
Comments:
- Use at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
- Re-evaluate periodically to determine if treatment is still necessary.
- Only the estradiol 1 mg/norethindrone 0.5 mg strength is recommended for vulvar and vaginal atrophy treatment.
Uses:
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
- Prevention of postmenopausal osteoporosis
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Contraindicated
Precautions
US BOXED WARNING(S):
CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER, AND PROBABLE DEMENTIA
Estrogen Plus Progestin Therapy:
Estrogen Alone Therapy:
Recommendation:
- Estrogens, with or without progestins, should be prescribed at the lowest effective dose for the shortest duration consistent with treatment goals and risks.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
More about estradiol / norethindrone
- Side effects
- Drug interactions
- During pregnancy
- Reviews (78)
- Imprints, shape & color data
- Pricing & coupons
- Drug class: sex hormone combinations
Patient resources
- Drug Information
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- Estradiol and norethindrone (Advanced Reading)
- Estradiol and norethindrone Transdermal (Advanced Reading)
- Estradiol and Norethindrone Tablets
- Estradiol and Norethindrone Patch
Other brands
CombiPatch, Activella, Mimvey, Lopreeza
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.