Skip to main content

Estradiol / norethindrone and Insomnia: What Users Say

Brand names: CombiPatch, Activella, Amabelz, Mimvey, Ena, Etyqa, Lopreeza, Mimvey Lo

Insomnia: mentioned by 9 users (9.3%)

Based on user experiences from 97 Estradiol / norethindrone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 17.5%
bleeding 12.4%
anxiety 10.3%
insomnia 9.3%
cramps 8.2%
night sweats 8.2%
bloating 6.2%
mood swings 6.2%
hair loss 5.2%
spotting 5.2%

Reviews for Estradiol / norethindrone

Commonly mentioned side effects
  • Mer...
  • Taken for 1 to 6 months
  • February 16, 2019

Estradiol / norethindrone for Postmenopausal Symptoms "I was experiencing anxiety attacks, mood swings, strange electrical shocking sensations, and having trouble sleeping more than 2 or 3 hours at a time, even when I was exhausted. This is a pricey fix, but it immediately took care of my symptoms, but I'm having light periods occasionally. If I forget to change the sticker, those symptoms return. I'm on the low dose. I'm so thankful for this drug, while I am not a fan of drugs in general, this has definitely helped my quality of life."

10 / 10
Was this helpful?YesNo
36 Report
  • Hot...
  • Taken for 1 to 6 months
  • May 30, 2018

Estradiol / norethindrone for Postmenopausal Symptoms "I am 54 years old and have had no period for about 2 years. My hot flashes were unbearable, also night sweats and trouble sleeping, anxiety - lots of issues. The CombiPatch has helped tremendously and in a short period of time. Feel like I have my life back to enjoy."

10 / 10
Was this helpful?YesNo
34 Report
  • Hot...
  • Taken for 2 to 5 years
  • September 4, 2020

Estradiol / norethindrone for Postmenopausal Symptoms "Started on the CombiPatch a few years ago, and it saved my postmenopausal life. The hot flashes, mood swings, sleepless nights, and everything else came to a halt, and I felt normal again. My big concern is right now they are on back order until October 31st. I only have two left, and we are trying to come up with an interim solution. Why does this company keep running out of the CombiPatch? Not great for your customers."

10 / 10
Was this helpful?YesNo
23 Report
  • Mar...
  • Taken for 6 months to 1 year
  • June 4, 2019

Estradiol / norethindrone for Postmenopausal Symptoms "Started the patch one year ago, it took away my symptoms almost immediately: hot flashes, sleepless nights, electrical shock feelings, anxiety for no reason. I am very happy with it, the downside is that I'm bleeding like a light period a lot and have some breast pain. Getting that checked out soon."

9 / 10
Was this helpful?YesNo
26 Report
  • JMa...
  • Taken for 1 to 6 months
  • December 14, 2018

Estradiol / norethindrone for Postmenopausal Symptoms "I was diagnosed with sudden early menopause. Severe migraines (worse than I ever had), anxiety and panic attacks, insomnia (barely sleeping), depression, and night sweats. I really started feeling 90% better within a couple of weeks. I’m sleeping. Anxiety is minimal, and I’m sleeping again. Minimal side effects, but I’ve had bloating and bad indigestion."

8 / 10
Was this helpful?YesNo
27 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • KMa...
  • Taken for 10 years or more
  • July 27, 2021

Estradiol / norethindrone for Postmenopausal Symptoms "I was on CombiPatch for many years but had to go off of it about a year ago after retiring. Unfortunately, Medicare does not cover CombiPatch. Although I am not sure that it is totally due to going off CombiPatch, I have experienced many changes over the last several months. Those include the return of hot flashes, difficulty sleeping, extreme memory loss and brain fog, irritability, a sense of sadness, possibly depression, achy joints, and just no joy in my life. I spoke to my GYN about it at my annual yesterday. The out-of-pocket cost of CombiPatch for me would be almost $230 a month, and I cannot afford that. Due to this, we are going to try a generic estrogen patch and an oral progesterone tablet. I’ll see how that goes, and if this does not relieve some of my symptoms, I would appreciate someone who is knowledgeable about how I could possibly get CombiPatch from Canada. I have no idea how this works, and I want to appreciate the information if someone can please help me. Thank you."

8 / 10
Was this helpful?YesNo
16 Report
  • Lou...
  • Taken for 5 to 10 years
  • May 2, 2019

Estradiol / norethindrone for Postmenopausal Symptoms "I was prescribed Activella for 5 years. It worked beautifully for me, and I felt good. I changed to Prempro because of insurance, and about 3 weeks into that change, I started developing breast tenderness, headache, and sleep issues. Unfortunately, I have to wait until October when I can change my insurance again to get back on Activella."

10 / 10
Was this helpful?YesNo
19 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 5, 2015

Estradiol / norethindrone for Postmenopausal Symptoms "My symptoms were slight, including flashes at night and some insomnia. Vaginal dryness was another concern. The patch has really helped. It's been almost a year since I started the patch. Early on, I had some spotting, but that has stopped. I am having some puffiness in the application area."

10 / 10
Was this helpful?YesNo
22 Report
  • kol...
  • April 29, 2021

For Postmenopausal Symptoms "When I was taking this medicine, I had lots of bleeding, pain in my calves, rashes, sleep problems, acne, etc. It did control my flashes and vaginal dryness, but I would not recommend it as it was not safe for me. I developed problems with my uterus because of it and decided to stop it right away. It has been a week since I stopped it, the bleeding is gone, I sleep all night, and so far no flashes."

1 / 10
Was this helpful?YesNo
0 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.