Comparing Amitriptyline vs Vortioxetine
| Amitriptyline | Vortioxetine |
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| Amitriptyline | Vortioxetine |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Vortioxetine may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits... View more |
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| More about Amitriptyline | More about Vortioxetine | ||||||||
| Ratings & Reviews | |||||||||
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Amitriptyline has an average rating of 7.6 out of 10 from a total of 1807 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 16% reported a negative effect. |
Vortioxetine has an average rating of 6.1 out of 10 from a total of 1566 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 31% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Amitriptyline side effects |
View all Vortioxetine side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all Amitriptyline prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
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N/A |
Trintellix | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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16 hours |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 717 drugs are known to interact with Amitriptyline:
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A total of 355 drugs are known to interact with Vortioxetine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
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| First Approval Date | |||||||||
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April 07, 1961 |
September 30, 2013 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
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