Comparing Amitriptyline vs Bupropion
Amitriptyline | Bupropion |
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Amitriptyline | Bupropion |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Related suggestions Depression
Migraine Prevention (Migraine Prophylaxis)
Persistent Depressive Disorder
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More about Amitriptyline | More about Bupropion | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1778 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
Bupropion has an average rating of 7.1 out of 10 from a total of 2869 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: amitriptyline side effects in more detail. |
See also: bupropion side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all amitriptyline prices |
View all bupropion prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
N/A |
Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
16 hours |
30 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 709 drugs are known to interact with amitriptyline:
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A total of 502 drugs are known to interact with bupropion:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
April 07, 1961 |
December 30, 1985 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.