Semaglutide and Loss Of Appetite: What Users Say (Page 4)

• mew...
• Taken for 1 to 6 months
• August 27, 2024

For Type 2 Diabetes "I’m 63 F with T2 diabetes, and I started on Oz mid-May 2024. Symptoms: nausea, fatigue, GERD, sulfur burps, stomach cramping from severe constipation, constipation, feeling like I need to vomit, ringing in my ears has increased significantly, loss of appetite, reduction of inflammation, occasional migraines, feeling “off” most days, bouts of dizziness, and feeling faint, but blood sugar and blood pressure are normal, improved blood sugar readings, weight loss of 13 lbs. There are some perks: rheumatoid and osteoarthritis inflammation has lessened, though I still feel pain daily, it’s more tolerable. I take no painkillers but will take CBD as needed. Loss of appetite has led to a loss of 13 lbs so far, blood sugar improved so I’m confident that my A1C has improved also. I struggle with what to do: stay on for the inflammatory reductions, weight loss, and blood sugar improvement benefits, or quit because I feel sick most days, so I have no real pleasure in life anymore. No, I’m not depressed."

• blh...
• Taken for less than 1 month
• May 31, 2024

For Weight Loss (Obesity/Overweight) "First dose 0.25mg, had slight stomach pain/discomfort. Later that same night, my appetite disappeared. Just seeing a fast-food commercial on TV made me feel nauseous. I thought if that's the worst of the side effects that affect me, then I'll be very happy with that. By the next day, stomach pain and nausea increased. By 4:00 am, BAM! Diarrhea, severe stomach pain, projectile vomiting, headache, chest pain, severe itching mainly on the palms of my hands and arms. I truly thought 'this must be what it feels like to be poisoned!' I was scared. It is now the next day and I feel fine. A little tired from lack of sleep from feeling so sick. I think I will do my second dose next week...but I'm quite nervous of a repeat of feeling like I was dying from the stomach pains and vomiting. Will I continue with this drug?...jury is still out! On the positive side, I've already lost 5 pounds; but of course, I can't & don't want to eat, too much nausea and vomiting."

• Nad...
• Taken for 2 to 5 years
• May 20, 2024

For Type 2 Diabetes "My main problem (Side effects): change of food tastes, very noticeable loss of appetite, don't feel hungry anymore, and some stomach problems with pain."

• dgb...
• Taken for 1 to 6 months
• June 24, 2023

For Type 2 Diabetes "Sick in the stomach, pain in the stomach, and dizziness! Worse as the dosage goes up. I am at 1 mg and have been sick all week! Extremely tired and want to sleep all the time! Have lost weight 15 lbs. always good. No appetite; nothing sounds good! I eat to relieve the pain in my stomach! Does not last! Easy to use! Such a tiny needle!"

• Re ...
• Taken for 1 to 6 months
• May 24, 2023

For Type 2 Diabetes "I experienced depression, reflux, constipation, and loss of appetite. Though I lost 10% of my weight in 2 months. I am on 0.5 mg."

• Ran...
• Taken for less than 1 month
• September 21, 2020

For Type 2 Diabetes "I've been taking Ozempic for two weeks now. I wondered how this drug could allow some - or most - people to lose weight. Now I know - it makes you feel sort of sick to your stomach and takes away your appetite - at least that is my result so far. I am hoping to develop a tolerance to it. Not a really pleasant experience so far, but I have not vomited or had diarrhea as some users have reported. It does appear to be lowering my blood glucose somewhat, which is the primary reason I am taking it. I am also taking metformin but have been able to reduce the dosage. I am still only taking 0.25 mg of Ozempic, so the result of higher dosages is unknown now. I will post again in a month or two with higher dosage usage results."

• Eda...
• Taken for 1 to 6 months
• February 6, 2020

For Type 2 Diabetes "So I have been on Ozempic for 5 weeks. I am tired a lot. Not sure if this is the drug or my poor sleep, but now that I see others are tired a lot, it makes me wonder. I have nasty burps a lot. I started on a dose of 0.25 for 4 weeks. I had a lot of low-level nausea, but not too bad except for one day. Then last Sunday, I took the higher dose of 0.5, and I was okay on Sunday and Monday, but Tuesday the nausea was horrible, and I had explosive diarrhea all day to the point I had to take Imodium, and I got my doctor's office to prescribe an anti-nausea med, Zofran, which helped a little. The next day, less nausea, and today is Thursday of that week, and I still have the burps and more BMs than I would like, as well as a lot of gas. I know I have lost weight just by how my clothes fit. I have very little appetite. Not sure if the pluses outweigh the minuses yet. I am probably going to try one more week and see how I feel. It has had a modest impact on blood sugars. I have been using less insulin."

• Sal...
• Taken for 6 months to 1 year
• January 29, 2020

For Type 2 Diabetes "Been on Ozempic for about 8 months. Everything was fine with 25 units. I've had a few bouts of low blood sugar. Dropped a little weight due to loss of appetite, and my A1C is almost normal = 6.7. Anyway, I may have to stop taking it because of the cost. My Part D has a $435.00 deductible for tier 3 drugs with a $42.00 copay. This drug is for rich people only. I'm on Social Security. How can anyone afford this? I'm very upset."

• Bai...
• Taken for less than 1 month
• July 3, 2019

For Type 2 Diabetes "At first, I had a brief overwhelming bout of nausea that passed. Decreased appetite definitely had me losing weight, but after the second injection, the nausea got much worse! Plus, I had diarrhea/vomiting, and it just got worse daily. I had to discontinue. Now it's been a month later, and I'm still having nausea and diarrhea. Horrible experience for me."

• Ano...
• April 18, 2025

For Type 2 Diabetes "Worked well at the beginning, and all my levels decreased, such as blood sugar and blood pressure, and the weight loss was good. But as time went on, the effects weren't as obvious. While my blood sugar and blood pressure remained at the desired levels, the appetite suppression was less effective, and I started getting contraction-type cramps in my lower left abdominal area. I'm just over 1 year on it now and considering giving up taking it, but waiting to see my doctor at the moment on the 1 ml dose."

• kem...
• Taken for 1 to 6 months
• October 3, 2024

For Type 2 Diabetes "My doctor switched my medication from automatic insulin to Ozempic, taken once a week, along with daily long-acting insulin injections. I lost my appetite, my mouth feels tasteless, and no food appeals to me, so I have to force myself to eat. My blood sugar levels have been unpredictable, fluctuating between highs of 250 and lows of 60. One minute it’s very low, and after eating, it shoots up, then drops again. I decided to stop the long-acting insulin last Sunday, at the start of the fourth week when my Ozempic dosage was increased from 0.25 to 0.5. Since then, things have slightly improved—my blood sugar isn’t running too low anymore, but it is still high. During this time, I’ve also developed severe heartburn, sleeplessness (only a few hours of sleep at night), and sluggishness, among other symptoms. I contacted my doctor yesterday."

• GEL...
• Taken for 1 to 6 months
• July 15, 2024

For Type 2 Diabetes "Find it difficult to take as it makes me quite nauseous. I have been taking it at 12 noon one hour before my lunch. I started off taking it at 3 a.m. when I usually awaken for a visit to the loo, and this lowered my blood glucose very well in the early morning, but then I was not getting enough sleep. However, I could not cope with the side effects and stopped taking it. Since reintroducing it, my morning glucose readings have been in the region of 12-15 mmol/l, which is not great. However, I am on 7mg of Rybelsus. I cannot drink more than 2 glasses of wine, which is good. Also, it has reduced my appetite substantially, which is also good, and I lost 3 kg in weight when I started taking it."

• car...
• Taken for 1 to 6 months
• March 23, 2023

For Type 2 Diabetes ".50 caused some gas, but 1.0 made it really bad. Loss of appetite."

• DLy...
• Taken for less than 1 month
• April 7, 2022

For Type 2 Diabetes "Have been taking the low dosage for 2 weeks now. I have no appetite and have dropped about 7 lbs during that time. The problem is constant GI pain. No nausea, just never-ending constipation and gut pain. I am taking myself off this until I can find an alternative. The weight loss is nice, but the pain just isn’t worth it."

• Chr...
• Taken for 1 to 6 months
• July 11, 2021

For Type 2 Diabetes "I suffered from - Loss of appetite - Exhaustion - Nausea - Vomiting (once a week, usually 2 days after my injection) - Low blood sugar events (probably caused because I just had no appetite). When I spoke to my pharmacist, she encouraged me to try to hang in there, telling me it would get better, and it finally has. I was not expecting it to take over 3 months though. My readings are all good, and I've lost 28 lbs, so there were benefits to sticking it out, but it was hard. I had decided that I would continue to take the medication until my next appointment, and if things were still bad, I would tell the doctor that I no longer wanted to use it. Things are better, and my appointment is next week."

• Con...
• Taken for 1 to 6 months
• February 1, 2021

For Type 2 Diabetes "I started Ozempic in late December at 0.25 injection. I also take 500mg metformin per day. Soon after I started Ozempic, I had decreased appetite and my sugars improved, but I had reflux, gas, bloating, nausea, and diarrhea. After 4 weeks, I started 0.50. 2 weeks in, I have bouts of painful constipation then diarrhea, nausea, bloating, gas, reflux, and cramping. I've almost vomited a few times. When I eat, it feels like the food just sits and sits, barely moving through my gut. My doctor wants me to stick with it, saying that these side effects usually improve, but it's been pretty miserable. I'm thinking I'm going to stop taking it. While Ozempic has been effective in regulating my sugars and losing weight, I don't think it's worth the suffering that I've been enduring on this medication. I understand that studies showed it causing thyroid cancer in mice, but no one knows if it causes thyroid cancer in humans. I don't want to be the guinea pig the drug makers use to find out it does."

• MDG...
• Taken for less than 1 month
• August 8, 2020

For Type 2 Diabetes "First, I started on Rybelsus, the 3mg dose, my blood sugar went up over 200. I stopped on the third day, went back to my old meds, and my levels returned to normal. No nausea, no diarrhea, no side effects of any kind. (I did follow the directions to take it first thing on an empty stomach and not eat for thirty minutes.) Dr. switched me to the 7mg dose, so far my blood sugar is running higher than my old meds. I am on day four, so I want to give it plenty of time. I do notice a lack of appetite. At this point, I am not impressed, but I am willing to give it more time before throwing in the towel."

• Rit...
• Taken for 1 to 6 months
• January 17, 2020

For Type 2 Diabetes "For the first three weeks on this drug, I had oscillating constipation and diarrhea. I felt very nauseous and did not want to eat much. After upping the dosage, the digestive problems have decreased, but I still feel nauseous and don't have much of an appetite. I have been on it since November and have lost 16 lbs. with Metformin, diet, and exercise."

• JRo...
• Taken for 1 to 6 months
• October 29, 2019

For Type 2 Diabetes "Within 2 weeks after moving from the starter dose of Ozempic to 0.25 to 0.5, I began having vomiting in the wee hours of the morning, with increasing intensity, nearly every night for the last 2+ weeks. The last 4-5 have been really rough. I also take metformin 500 and glimepiride 2, both AM and PM. This weekend, I went down to the Ozempic 0.25 dose, but Sunday and Monday nights were both awful bouts of vomiting. (No diarrhea at any stage with Ozempic; occasional nausea during the day, very decreased appetite.) Is anyone else having this bad and persistent vomiting? Thanks and good luck."

• Anonymous
• Taken for 1 to 6 months
• April 11, 2023

For Type 2 Diabetes "I am 20 years old and was diagnosed at age 17 with type 2 diabetes. My A1C started off not bad, I was pre-diabetic for a year and then progressed to diabetes. I’ve been on metformin for 4 years and am currently on 2500 mg. I got my A1C blood test back and it was high, so my doctor recommended Ozempic. I’ve been on it for 5 weeks and it was horrible. I was vomiting nearly every day, had terrible cramps, especially at night, so painful I couldn’t sleep, horrible, disgusting-smelling burps like eggs, and the nausea was horrendous. I haven’t had much of an appetite, sometimes the thought of food makes me feel sick. I’ve lost 6 kg in this time, but I’m not entirely sure it’s worth it. I’m currently on 0.25 mg at the moment and due for an increase to 0.50 mg. I’m not sure if I will stay on it. It’s incredibly hard to find supply as everyone wants it, and it kind of makes me mad that people are taking it off-label when there are genuine people with type 2 who need it."

• All...
• Taken for 1 to 6 months
• March 15, 2023

For Weight Loss (Obesity/Overweight) "I took 4 shots of .25 Wegovy. The first shot had no side effects and no problems. The second shot was a little different. Mild upset stomach starting about 24 hours afterward with some stomach pain. This subsided within the third day. My appetite was suppressed, felt fuller for longer. In the third shot, I had no appetite with stomach pain that lasted two days, and also felt as if I were going to pass out. I drank orange juice and ate saltine crackers with peanut butter, which helped. The last .25 shot of Wegovy… I had lost 12 pounds by this shot. But within a day, I was projectile vomiting, upset stomach, extreme pain in my abdomen, chills, and dizziness. I was taken to the emergency room. I was diagnosed with colitis that had gone to sepsis. The doctor explained a side effect from Wegovy may cause gastrointestinal problems. Wegovy attacked my colon and in turn, sepsis formed. I will not continue this shot. So many side effects go with it. It does curve your appetite, but I would be very cautious."

• Pat...
• Taken for 1 to 6 months
• August 29, 2022

For Type 2 Diabetes "I have been taking this drug for about 8 weeks, starting out with the 0.25 dose and now on the 0.5 dose. I have felt miserable the whole time, with nausea similar to pregnancy and with a revulsion to most food and smells of food cooking. Definitely low energy. I have lost weight, and I haven’t had my A1C checked since I started. I will see my doctor in a couple of weeks and will be telling her that I can’t continue to live this way. I’m 75 years young and don’t want to live the rest of my years feeling bad! Unusual, hiccup-type burps, coming out of nowhere and no appetite. Convenient once-a-week administration."

• Geo...
• Taken for less than 1 month
• February 23, 2022

For Type 2 Diabetes "Been on Rybelsus 3 mg for 16 days. Sugars have improved somewhat already, and weight down about 5 pounds, unexpected. BUT, no appetite, stomach feels full all the time, hard to even drink enough water each day because stomach so uncomfortable. Constipation that is not very responsive to Miralax. Cold hands. Some nausea. More heartburn than usual. Increased fatigue. And the worst is: dizziness and/or vertigo and a feeling of weird fullness in my head along with tinnitus. What the heck? Given the high cost, and that I've all these effects even before going on the 7 mg dosage, I don't think it's worth it."

• CRK...
• Taken for less than 1 month
• July 16, 2021

For Type 2 Diabetes "My doctor gave me a sample box of 3 mg Rybelsus for T2D. I could only tolerate it for 10 days. The first thing I noticed was my appetite was gone. As days went on, I felt like I was in my first trimester of pregnancy, although I didn’t ever feel like vomiting. Continuous nausea, lack of appetite, lethargy, and horrible constipation were my friends during the time I took the drug and for about a week afterward. I ended up in the ER with terrible IBS with very painful cramps. I thought I had a blockage from no BMs for 12 days. After being off the drug for about a week, one day I woke up and the symptoms were gone (about a week after I stopped taking it). I felt like myself again. During that short time period, the pounds just started melting off me, and I only weighed 138 going into this. I dropped down to 130. I really wanted this drug to work for me. My doctor tried to prescribe Trulicity after this. No way. It’s too similar. My A1C is 8. Not sure where to go from here."

• Ann...
• Taken for 1 to 6 months
• February 27, 2025

For Type 2 Diabetes "For the first 4 weeks, I took a 2.5 dosage. I lost 1 pound in 4 weeks. Very unhappy. Started on point 5 on Monday, and I am feeling nauseous and have no appetite, so I hope this clears up."