Semaglutide and Loss Of Appetite: What Users Say

• Dai...
• Taken for less than 1 month
• January 23, 2023

"I wanted to write this early in the process of taking this medication because I know how it feels to be scared to take this tablet. I’m on it for weight loss in the UK cost £139. I read a tip to take it early in the morning, I usually take it between 4 am-6 am. I started taking it 2 days ago. The first day I felt fine with no side effects, the second day I was feeling a bit nauseous but it was manageable. Today my appetite has decreased already and I only want small amounts to eat, the thought of a large meal makes me feel ill. I’m intrigued to know if this will stay or go. If it lasts I will be one of the lucky ones. I weigh about 268 lbs so I will come back in two weeks and let you know. I hope the side effects don’t ramp up each day I take it. We will see."

• Bac...
• Taken for 1 to 6 months
• March 9, 2023

For Weight Loss (Obesity/Overweight) "I started Wegovy 6 weeks ago at 0.25 mg for 4 weeks, and for the last 2 weeks at 1 mg. I started at 211 lbs and am now 197 lbs, so have lost 14 lbs and counting in 6 weeks. Not bad! Symptoms I've experienced include being slightly more tired than usual on the day of the injection, and some constipation at first but I use Miralax if there's an issue and it works fine for me. I haven't had any extreme nausea, but the injection definitely makes me less hungry and there are certain foods that I feel slightly queasy even considering eating-like high-fat foods-so I don't eat them. I eat a lot more fruits and vegetables and get full very quickly. I work out 4-5 days a week, my energy has been good and I feel like I'm getting back to my old self. I'd like to be about 135 lbs eventually. Wegovy has been a lifesaver. I'm 55 years old and had considerable cravings, especially at night. I'm happy to be free of them. I hope to make my new habits permanent."

• Con...
• Taken for 1 to 6 months
• February 1, 2021

For Type 2 Diabetes "I started Ozempic in late December at 0.25 injection. I also take 500mg metformin per day. Soon after I started Ozempic, I had decreased appetite and my sugars improved, but I had reflux, gas, bloating, nausea, and diarrhea. After 4 weeks, I started 0.50. 2 weeks in, I have bouts of painful constipation then diarrhea, nausea, bloating, gas, reflux, and cramping. I've almost vomited a few times. When I eat, it feels like the food just sits and sits, barely moving through my gut. My doctor wants me to stick with it, saying that these side effects usually improve, but it's been pretty miserable. I'm thinking I'm going to stop taking it. While Ozempic has been effective in regulating my sugars and losing weight, I don't think it's worth the suffering that I've been enduring on this medication. I understand that studies showed it causing thyroid cancer in mice, but no one knows if it causes thyroid cancer in humans. I don't want to be the guinea pig the drug makers use to find out it does."

• eli...
• April 3, 2023

For Weight Loss (Obesity/Overweight) "Started on 0.25 mg. Had some side effects but not enough to stop taking it. Nausea, but not terrible, heartburn which was bad at times, Pepto-Bismol sorted it out (have some on hand). Curbed appetite, but noticed it starting to not be so effective when it was time to up the dose. I am now on 0.5 mg. The third week, and I am on a new dose, and there's a big change. I have heartburn most of the time, especially if I try to eat starchy carbs (1 slice of bread). Nausea here and there, but since I took the third dose of 0.5 mg, I have absolutely zero appetite. I know I should eat, but 1 or 2 mouthfuls of food is enough for me. I lost 12 lbs in the first month and will weigh myself at the end of the second month. Conclusion: if you really can't stop eating, and your health is suffering, speak to your doctor about Wegovy. It's not a magic wand, but will definitely help you. Make sure you drink plenty of water throughout the day."

• Sno...
• Taken for 6 months to 1 year
• July 16, 2019

For Type 2 Diabetes "Side effects are mild for me, but it really decreases your appetite. Initially, I could only tolerate fresh fruits and vegetables. I took this as an opportunity to change my lifestyle. I eat healthier and avoided sugary drinks. I lost a total of 40 lbs. in 6 months. A1C dropped from 7.3 to 5.4. Dress size dropped from 14 to size 4. I am no longer on daily insulin, BP meds, and cholesterol meds. All labs are normal. This medication is my lifesaver."

• Gum...
• Taken for 1 to 6 months
• February 28, 2020

For Type 2 Diabetes "I’ve been on Rybelsus since 1 December at a dose of 3 mg. January 1, I started 7mg. I don’t like taking medication and was scared of this medication due to other reviews I have read. I am very pleased with the outcome. I lost 5 lbs with very little exercise. My side effects were nausea and loss of appetite. Nausea only occurred when I ate junk food and sweets. A1c down from 7 to 6.2. Plus, I do not take any other meds for diabetes. Hope my review will help others. February 28."

• Koo...
• May 1, 2021

For Type 2 Diabetes "I have been taking Rybelsus for 6 months. At first, I was nauseous and had bad sulfur burps, but it went away. My A1C is the best it's been in 9 years. I have had a hard time treating my diabetes, as most other oral medications and daily injections just made life harder. Now, my numbers are 6.7, and I have lost a significant amount of weight, 335 lb to 285 lb, with minimal effort. It definitely suppresses my appetite. I've read you can only lose a few pounds, but I feel like a lucky one."

• Chr...
• Taken for 1 to 6 months
• July 11, 2021

For Type 2 Diabetes "I suffered from - Loss of appetite - Exhaustion - Nausea - Vomiting (once a week, usually 2 days after my injection) - Low blood sugar events (probably caused because I just had no appetite). When I spoke to my pharmacist, she encouraged me to try to hang in there, telling me it would get better, and it finally has. I was not expecting it to take over 3 months though. My readings are all good, and I've lost 28 lbs, so there were benefits to sticking it out, but it was hard. I had decided that I would continue to take the medication until my next appointment, and if things were still bad, I would tell the doctor that I no longer wanted to use it. Things are better, and my appointment is next week."

• Nw2...
• Taken for 1 to 6 months
• June 20, 2021

For Type 2 Diabetes "Started April 1, 2021, on Ozempic low dose. 3-week intervals it was increased. Side effects were constipation (went on laxatives to help), pain in my back (severe), bloating. Week 11 increased to 1mg, the side effects were major bloating, diarrhea, sounds in my stomach (crazy), nauseous, feeling under the weather. My appetite has decreased to the point that I only eat 2 meals a day that are small. My sugar levels have decreased from 7.1 to 5.2 A1C. I’ve noticed that I have been kept awake some nights like I’m nervous for some reason. In the first 3 weeks, I’ve lost 15 pounds. Haven’t checked since I want to wait but can feel a difference. The pains in the stomach are really uncomfortable, and the bloating I will try gas-x for relief. When I try to eat more than I should, my body tells me that I’m full. If I go beyond that point, I get severe pains in the stomach for hours. But depends on what I eat. Going to stay with smaller portions/healthier foods."

• Lor...
• Taken for less than 1 month
• October 3, 2023

For Weight Loss (Obesity/Overweight) "I was prescribed Wegovy for weight loss purposes. I’m 5’11, 225 pounds, with a BMI of 31%, so I can be considered obese. I’ve been on it for one week and have lost 7 pounds. I’m starting with the lowest dosage (0.25). First of all, the injection was completely painless (for me). I also inject Humira bi-weekly, so maybe I’m just used to it, but I was shocked to feel absolutely nothing. I questioned if I was doing it right, it was so painless. Do not let some testimonials scare you! I did a lot of research while waiting for the drug to come back into stock. 90% of what I read were complaints about vomiting, diarrhea, some people getting so sick they had to go off of it. Some of these reviews were written after only a week or two of the drug usage. So far, my personal experience has been completely different than what I’ve read. That could change as I go up in dosage. As of right now, the only side effect I’m experiencing is a complete lack of appetite."

• Sai...
• October 17, 2020

For Type 2 Diabetes "Dr. ordered 3mg 30 days ago to be added to Metformin 2000mg. Blood sugars have decreased from a range of 200-350 to 120-150. Weight reduced by 14 pounds. I experienced nausea and fullness for the first two weeks. That has tapered off but appetite suppression has continued. After a month, the doctor is pleased with the results, as am I. He has ordered me to continue on the 3mg and my insurance has agreed to cover it with a copay I can afford. I am so grateful for this new med!"

• joa...
• Taken for 1 to 6 months
• August 15, 2020

For Type 2 Diabetes "Dr put me on Rybelsus since I had bad luck with Trulicity and feeling sick every time I took the shot. The first month of the dose 3mg, I noticed I never ate. I had a complete lack of appetite. I was exhausted, had weird dreams, and a constant feeling of anxiety, and sometimes insomnia. I put up with it. The second round with the 7 mg, the first day I was sicker than heck. I felt like I was on a cliff dangling, my anxiety turned into panic, rapid heartbeat, and I was unable to sleep. I stopped after day 4. I called the doctor but she never got back to me. I am debating trying to take 7mg every other day or go back to the 3mg and see if there is a difference now that it is almost out of my system. It is brutal to the body. The warnings say nothing about the feelings of anxiety or the insomnia."

• Kay...
• Taken for 1 to 6 months
• August 16, 2020

For Type 2 Diabetes "With an A1C approaching 11, it was time to try something else in addition to Novolog and Tresiba, so my doctor added Ozempic. I also quit all alcohol and became a vegetarian. The first 3 weeks at 0.25 left me with a decreased appetite, nothing severe. The pounds started dropping off, fast forward 3 months and I am 22 lbs lighter. I love Ozempic, no bad side effects, and my insulin needs have decreased (not gone away), best of all, my A1C was 7! A lifestyle change helped a lot, but I credit Ozempic for many of these positive changes."

• CAD...
• Taken for 1 to 6 months
• December 13, 2020

For Type 2 Diabetes "I’m prediabetic, HbA1c 5.7. And I’ve been struggling to lose weight for 20 years. I have an excellent diet, but I eat too much. I’m hungry all the time. I started Rybelsus (paying out of pocket - Ouch) to see if it’s worth hassling my insurance company. On 3 mg, I felt nothing - no nausea, but experienced loose stools. When I went to 7 mg, I felt nausea for 1 hour after taking the pill and decreased appetite the rest of the day. I am easily staying on my 1400-1500 calorie diet, which has never been easy for me in the past. At 1 month of 7 mg, I’ve lost 8 pounds (255 to 247) and feel very encouraged. The science behind this medicine is inspiring."

• Sta...
• Taken for 1 to 2 years
• February 15, 2024

For Weight Loss (Obesity/Overweight) "It has been a year since I have been on Wegovy. I went up to 2.4 by August 1, 2023, and had lost 50 pounds in those six months. The last 6 months I have not lost any weight. I have not gained but definitely stalled for 6 months. I just went down to 1.7 last week to see if the high dose of 2.4 is the reason for the stall. Appetite suppression also stopped at 8 months. No clue what to do, but I will stay on 1.7 for a month to see if it changes the stall. Good luck, everyone! I have a whole new life after losing 50 pounds! Life is good!"

• OR ...
• Taken for 1 to 6 months
• July 3, 2022

For Weight Loss (Obesity/Overweight) "I lost 75 lbs on Wegovy. It wasn't worth it. People assume I have all this energy now. I feel like a shell of my former self. Run down, no appetite... and just got back from the hospital since I didn't have a bowel movement for almost 2 weeks once I was at the 2.4 dose. I can't recommend this drug. You will essentially give up your normal life to lose weight. To me, the benefits don't outweigh the risks."

• Ano...
• April 18, 2025

For Type 2 Diabetes "Worked well at the beginning, and all my levels decreased, such as blood sugar and blood pressure, and the weight loss was good. But as time went on, the effects weren't as obvious. While my blood sugar and blood pressure remained at the desired levels, the appetite suppression was less effective, and I started getting contraction-type cramps in my lower left abdominal area. I'm just over 1 year on it now and considering giving up taking it, but waiting to see my doctor at the moment on the 1 ml dose."

• AMa...
• January 2, 2022

For Weight Loss (Obesity/Overweight) "I’m on Week 15 of treatment and have lost nothing. On the first dose of 0.75 mg, I experienced heartburn, fullness, and zero appetite for 5 days. I was hopeful that it had finally started to work. On subsequent doses of 0.75 mg and 1 mg, and now on 1.7 mg, I’ve felt no effects from Wegovy. I’ve tried switching injection sites from my abdomen to my arm with no effect."

• Lau...
• Taken for 1 to 6 months
• April 1, 2020

For Type 2 Diabetes "I have been prescribed Ozempic for weight loss secondary to type 2. I got nauseated with some loss of appetite at 0.25 mg dosage and adapted to it over a month. Lost 9 lbs in that month. I increased to 0.5 mg last Friday (it is Tuesday), and I am miserable. Non-stop nausea, burping, some pain in the stomach, constipated. I feel miserable. I am worried about the stomach pain being pancreatitis starting, so I am increasing my water. I haven't eaten in two days. I will not continue with this drug as I think this just cannot be a good thing to do to one's body."

• Me ...
• Taken for 1 to 6 months
• January 25, 2022

For Weight Loss (Obesity/Overweight) "Nausea, diarrhea, constipation, sulfur burps, fatigue, loss of appetite, super sensitive to smells, I have to make myself eat enough. It's like morning sickness, only it's 24/7. Zofran helps for about 6 hours. Cannot tolerate much besides chicken broth and Brussels sprouts. No fried, fatty, oily, spicy foods. Need to stay hydrated with water. Ginger ale helps. I'm up to a 1 mg dose and 14th week. This nausea is constant and impacts my daily routine significantly. However, it is the only effective weight loss option that's worked in 26 years of diets and exercise and eating healthy. I will not give up. The weight is killing me, and I needed this medication. I started at 221 lbs. and now I'm at 194.3 lbs. BMI is close to pre-obesity, and I know I'll cry the day I hit it. Full disclosure, I'm disabled in part due to my weight. There is no way I could have worked and taken Wegovy with the severity of my nausea and fatigue. But the mobility and breathing issues are improving."

• Abe...
• Taken for 1 to 6 months
• November 15, 2021

For Weight Loss (Obesity/Overweight) "Started out with .25 mg. I did that for four weeks and only felt slight nausea after the injection. Today, I bumped up to the .50 mg dose, and within five hours I was nauseous. I finally vomited, and I feel better, but have no appetite now. Nothing sounds good. I’m also sleepy. So far, the weight loss is only about five pounds. If I stay nauseated, it’ll probably increase drastically, but what a dumb way to live! I hope it’s temporary. I could be sick once a week and survive if I get decent weight loss. I am also fairly active, and I exercise 4-5 times a week. I don’t have a thyroid because of cancer nine years ago."

• Dad...
• Taken for 6 months to 1 year
• October 13, 2019

For Type 2 Diabetes "This Ozempic was prescribed as a last-ditch effort to get my A1C down prior to starting insulin. The first 0.25 dose caused significant nausea, but I battled through it for a couple of weeks before starting the 0.50 dose. The nausea increased with the higher dose, and I considered stopping but had lost ten pounds, had zero appetite, and my sugar was down, so I chose to continue. It's been about 6 months now, I'm taking the full 1.0 dose, and although the nausea is still an issue, it has lessened in severity and comes in 'waves,' so I know it will pass and just tough it through. I've dropped about 30 lbs and counting, my A1C is now in the prediabetic range, and I've been able to lower doses of other medications that were causing significant side effects. I now feel better, look better, have more energy, and no longer have the constant food cravings or desire to overeat. If you can ride out the nausea, the benefits of Ozempic are huge, for me anyway."

• Jer...
• Taken for 1 to 6 months
• June 20, 2023

For Type 2 Diabetes "It was a disaster for me. My A1C used to stay between 7.5 and 8.5, and morning fasting readings were high, like 130 to 160. Increasing Glimepiride from 4 mg up to 8 mg didn't work. My doctor started me on 3 mg/day of Rybelsus. It caused constipation, upset stomach, and a lot of burping. But morning fasting readings came down to around 100, so I was tempted to try it out. After finishing the 3 mg dose for 30 days, I started taking 7 mg/day. My symptoms worsened: constipation, loss of appetite, noisy stomach, lots of burping, GERD, and weight loss from 152 lbs to 139 lbs in just about a couple of months. I could not afford to lose any more weight. I also saw some foamy urine indicating it was affecting my kidney function too. I stopped taking Rybelsus under my doctor's advice, and since then, the constipation is gone, the burping is gone, the appetite is good, and life seems back to normal. I still need to check on my kidneys for any issues since foamy urine is still there. The last A1C was 7.9."

• Ran...
• Taken for less than 1 month
• September 21, 2020

For Type 2 Diabetes "I've been taking Ozempic for two weeks now. I wondered how this drug could allow some - or most - people to lose weight. Now I know - it makes you feel sort of sick to your stomach and takes away your appetite - at least that is my result so far. I am hoping to develop a tolerance to it. Not a really pleasant experience so far, but I have not vomited or had diarrhea as some users have reported. It does appear to be lowering my blood glucose somewhat, which is the primary reason I am taking it. I am also taking metformin but have been able to reduce the dosage. I am still only taking 0.25 mg of Ozempic, so the result of higher dosages is unknown now. I will post again in a month or two with higher dosage usage results."

• L0v...
• Taken for less than 1 month
• March 14, 2020

For Type 2 Diabetes "Second day on Rybelsus 3 mg. I was too afraid to try it, but I'm glad I did. No side effects at all except for the loss of appetite. I will return and provide an update. I need to lose 60 lbs. I have tried Victoza and Invokana and got very sick within the first couple of days of taking them, so I hope Rybelsus is the answer for me. I exercise and watch my diet, but my glucose levels were still too high."