Semaglutide and Diarrhea: What Users Say

• Nao...
• Taken for 1 to 2 years
• April 9, 2025

Semaglutide for Type 2 Diabetes "My A1C had gone up as high as 8.0, and my doctor kept adding medications to my arsenal of drugs to control my diabetes. I was taking so many drugs but was getting terrible side effects, including kidney stones, liver enzymes over 600, diarrhea, nausea, and finally, I was hospitalized and taken off all my drugs, but then my diabetes was out of control. Finally, my GI specialist recommended starting with Ozempic .5, and that's when everything started to change. At first, I didn't see much change in my weight loss, so my doctor raised it to 1mm. It was then that I saw my A1C go down to 7.2, and I had lost 10 pounds without trying. Now I have been taking Ozempic for over a year, and my A1C is down to 6.7, and I dropped 20 pounds. I don't have any side effects unless I overeat, which I avoid. If I overeat, I get an uncomfortable feeling in my stomach, but within a short period, it subsides. I wish my mother would have had the ability to get Ozempic 10 years ago, maybe she'd be alive today."

• Bit...
• Taken for 6 months to 1 year
• March 23, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy in April 2024. I was 193 lbs at just between 5’1”-5’2.5. I had tried everything, but food noise and the fact that being so short, the calorie intake had to be so low to lose weight. Anyway, the first thing I noticed was a bit of nausea. That went away after a few days. I have had very minimal side effects. Sometimes a little nausea, constipation, or diarrhea. Nothing to really disrupt my life. For the first time in my life, I actually can tell when I am full. My IBS has been almost non-existent. I’m more awake. I have fewer sweet cravings. The food noise is still there, but my stomach is able to signal my brain that if I eat more, I will feel sick. I have lost to date 4/2024-3/2025, 63 lbs. I am just about to hit my normal weight goal. I knew how to lose the weight. I am someone who has a very difficult time shedding the weight with exercise and diet. I am super grateful for this opportunity to prove that a drug works so well."

• Ten...
• Taken for 1 to 2 years
• March 13, 2025

Semaglutide "Been on Ozempic & Metformin for 1 year now for weight loss. I felt a little side effects in the beginning, but nothing scary or concerning, a little diarrhea, which was fine because I suffer from IBM. I’m happy with my weight loss, starting out 198 lbs, now 150 lbs, height 5’1. My doctor said to continue taking it because when asked if I should come off, the reason why he thinks I might gain the weight back. Only complaint is the loose skin looks terrible. I wonder if I will ever be able to tighten up with exercise."

• Tra...
• Taken for 1 to 6 months
• February 25, 2025

Semaglutide for Type 2 Diabetes "Rybelsus has worked wonders for me. I started with the 3 mg for 1st month, then 7 mg for 3 mos. Still on my 3rd bottle, almost done. I'm 50 yrs old and weighed 271 lbs and now am at 249 lbs and lost 22 lbs; my A1C went from 8.4 to 5.3. I'm completely satisfied with my results. It really does suppress your appetite. I've had a few bouts of constipation, diarrhea, and nausea when I 1st started it. It wasn't right away either. However, there are no more side effects. I'm good over here!! Make sure you use the discount from the manufacturer online. $10/mo"

• Sus...
• Taken for 1 to 6 months
• February 19, 2025

Semaglutide for Cardiovascular Risk Reduction "Ozempic gave me unbelievable diarrhea and I vomited on my baby more than she vomited on me. However, I have lost 24 kg in just a few weeks."

• Ann...
• Taken for 1 to 6 months
• January 28, 2025

For Type 2 Diabetes "Dreadful diarrhea lasting a day each week. I have lost 11 lbs in two months. I take tablets as I am on a trial."

• Fla...
• Taken for 1 to 6 months
• January 14, 2025

Semaglutide for Type 2 Diabetes "Took a few weeks for results to show. Started at 270, and at 247, I started getting diarrhea, bloated, cramps, blurry-eyed, dizzy, fainted, low blood sugar. I had to quit to test if this was the Ozempic or one of my many other medical issues."

• Sue...
• Taken for 2 to 5 years
• January 3, 2025

Semaglutide for Type 2 Diabetes "Severe diarrhea, but nothing you can’t handle! Blood sugar is going down."

• Sco...
• Taken for less than 1 month
• December 28, 2024

Semaglutide for Cardiovascular Risk Reduction "So far, so good. I’ve been on it for 4 weeks now. I did have gas and stomach pain, nausea, and diarrhea, but that was in the beginning, and it’s lightened up a lot."

• Per...
• Taken for 1 to 2 years
• December 26, 2024

Semaglutide for Type 2 Diabetes "Ozempic has helped me, so I do not have to take insulin. When I first started it, I had tummy aches, but now that I have been on it for the past three months, no problems with that. You do have to be careful about how much you eat, Ozempic has helped me regulate how I eat and what I eat. If you overeat, you may end up with a bad case of diarrhea, but that doesn't happen very often anymore. One more thing, if you come off the Ozempic, you may see a spike in your blood sugar. Overall, I really don't have a problem with taking Ozempic."

• Jan...
• Taken for 1 to 6 months
• September 12, 2024

For Weight Loss (Obesity/Overweight) "The first month was great, weight loss of 14 lbs. Felt fine. But the 5th week increased injection to 2, the fourth day I had terrible stomach pain, diarrhea, vomiting, got better but still have heartburn, burping, and unable to go to the bathroom. I take omeprazole and Peptic as I have GERD! But has not helped! Tried Pepto-Bismol, doesn’t help!"

• Bar...
• Taken for 6 months to 1 year
• September 3, 2024

Semaglutide for Type 2 Diabetes "I had already lost 60 lb before taking Ozempic. I've been on Ozempic for about 5 months and have lost another 10 lbs (now at 220#). I have found that eating oatmeal and taking an OTC anti-diarrheal, I handle these problems very well. The good news is my A1c is now 6.3. My morning finger sticks run between 95 and 107. Once a week very easy to use. I don't even feel the injections. The bad news: recurring diarrhea, constipation, and stomach gas and belching."

• All...
• Taken for 2 to 5 years
• August 23, 2024

Semaglutide for Type 2 Diabetes "I was prescribed Ozempic because of type 2 diabetes, an overweight condition, and needing a quadruple bypass surgery. Ozempic immediately started my weight loss journey, I had a surgery wait time of 15 weeks. In that time, I lost close to 60 lbs. Post-surgery, I lost another 10 lbs. 2.5 years later, I am a happy 75-year-old male maintaining a weight of 45 to 49 lbs. My side effects are gastrointestinal, primarily. I cycle through constipation and diarrhea week by week. My appetite has been reduced, my energy has increased. I now take 0.75 mg weekly, my A1C last time was 6.4. For me, the benefit of taking Ozempic far outweighs the negatives of using the drug. This is just one person's experience, I assume that everyone has their own unique experience with this drug. I have to say that mine has been all positive."

• Dav...
• Taken for 6 months to 1 year
• August 23, 2024

Semaglutide "I started using Rybelsus in October of 2023. My starting dosage was 3 mg, and then raised to 7 mg about 4 months later. I have encountered redness, hives, and itching on my calves, scaly skin, diarrhea, constipation, nausea, cramping, and dizziness. Most of those symptoms have gone away. I take it each morning alone and do not take anything else for at least 30 minutes. When I get to work, an hour later, I take my heart and blood pressure medicine (for Afib). I gained a lot of weight for multiple reasons. The main reason was because of depression and chronic back disease. I just had lower back fusion, which has stopped my back pain. This means I can exercise now without severe pain. The good news: since I have been taking Rybelsus, I have lost 70 pounds. I now weigh 330, and by January 1, 2025, I want to be 299. It works, but does have side effects. The key is using it as directed and learning to eat smaller, healthier food portions."

• Lau...
• Taken for 1 to 6 months
• July 25, 2024

Semaglutide "I noticed my husband, who is diabetic, losing weight even though his food intake was not lessened much. For myself, I exercise for approximately 2 hours every day, eat very little, and my weight does not shift. So, in trying Ozempic, in one month, I have lost 10 lbs (eating some naughty things) but mostly just eating like 'normal' people. I feel like I can cheat a little, and my body still eliminates the calories. Being tired of not enjoying food and feeling guilty if I did was a terrible trap. This weight loss keeps me encouraged. I feel no side effects that I have not had from dieting in the past, like diarrhea or constipation, but the diarrhea only lasted a day. The constipation lasted 4 days, and then I was fine. I am a normal, healthy person, so using this drug does not cause me any other side effects. Listing every possible side effect is just a legal requirement, in my opinion. I take a 1 mg dose, am a 67-year-old woman, and have tried every possible form of weight loss. In 67 years, I finally feel free!"

• Sem...
• Taken for 1 to 6 months
• July 24, 2024

For Weight Loss (Obesity/Overweight) "I have burping and nausea for 2 days after my injection. Currently, I am having diarrhea for 2 days. Not sure if it’s the meds or if I have a stomach virus."

• JRO...
• Taken for less than 1 month
• June 23, 2023

For Weight Loss (Obesity/Overweight) "Day two of initial dosage, shot. No side effects at all at this point. Was told it was good I was working from home as I might feel diarrhea, dizziness, and tenderness in the stomach area. So far, nothing, all normal for me. I’ll update routinely. I am high-end obese, high muscle density, normal BP, HR, and cholesterol. I do have PVC but no impact. I played ice hockey the night of the first dosage, I played better than most nights, only a coincidence. I note this only to illustrate normal life activities so far. Too early to report weight loss."

• Edd...
• Taken for 6 months to 1 year
• June 3, 2023

Semaglutide for Type 2 Diabetes "Around November 1, 2022, my doctor told me I had to face the fact I was a Type 2 diabetic. Although my A1C was 5.9, my fasting glucose was 147, and my triglycerides were close to 600. I am 6' 1" tall, and my weight was 278 pounds, which made me obese. It is now June 1, 2023. I am 68 years old. After 6 months, without even dieting, my weight is 231 pounds, my fasting glucose was 92 and 100 (measured on two occasions), my triglycerides were down below 200, and my A1C was 4.6. The side effects from Ozempic are as others say-- gas (which is countered by taking Gas-X chewable pills), constipation, and sometimes diarrhea. It is manageable. I was raised to 2 mg of Ozempic within 3 months, which is what I am on now. One thing I have learned is that you cannot overeat. If you do, you will regret it. You must eat manageable portions spread out throughout the day. I plan to increase my exercise routines, but Ozempic is working without it."

• Won...
• Taken for 6 months to 1 year
• September 9, 2022

Semaglutide for Type 2 Diabetes "Was placed on this medication to help with PCOS-caused insulin resistance and obesity. The first two months were a bit uncomfortable - I was nauseated a lot and had bouts of constipation and diarrhea. Fortunately, immediately starting it, my sugar cravings disappeared. I think I had a rough couple of months because of my old eating habits since this medicine slows how fast your stomach empties. As I developed better eating habits, this has gone away completely. I’ve been on this for almost a year now and have lost almost 60 lbs. I’m about 5 lbs away from being a normal weight and I’m barely making any effort at this point; the weight is just coming off. I feel the healthiest I’ve felt in over a decade and have been seeing my PCOS symptoms reduce as the weight comes off. This medicine was a miracle for me. I’ve struggled for a decade trying to get my weight under control. Once the insulin resistance was resolved, it literally fell off."

• Pat...
• Taken for 6 months to 1 year
• September 4, 2022

For Cardiovascular Risk Reduction "I started taking Ozempic one year ago: 4 weeks at .25, 4 weeks at .5, and then 1 mg for the remainder of the year. My A1C has fallen from 6.9 (diabetes) to 5.6 (normal), and I have lost 48 pounds. My blood pressure was high, and now it is 120/76 without medication. I had serious diarrhea for about two weeks when I went from the .5 dose to the 1 mg dose, but I waited it out, and it eventually went away, and I have had constipation off and on. Those are the only side effects. I am 65 years old, and I never thought I could lose this much weight and normalize my blood sugar. I have another 50 pounds to lose, so my doctor is going to move me to the 2 mg dose to see if that helps with the weight loss, since my weight loss has slowed down. I highly recommend sticking out the side effects for a few weeks to see if they improve."

• sam...
• Taken for 1 to 6 months
• July 21, 2022

Semaglutide for Cardiovascular Risk Reduction "I always struggled to lose weight in my life due to a big appetite. Now at age 34, after 3 C-sections, I was at the highest point of my weight, 81 kg at 5'3" height. I started Ozempic from 0.25 mg, and now I am in week 7 and taking a 1 mg dose. In 7 weeks, I have lost 15 lbs. I can't be more than happy. I had mild side effects here and there: nausea and diarrhea, but nothing I can't handle. It has cut my appetite by 90%. I will take it until I reach my normal BMI. Totally a game changer and lifesaver. I will keep you posted."

• pco...
• Taken for 1 to 6 months
• July 16, 2022

Semaglutide for Type 2 Diabetes "I started Rybelsus 3 mg at the beginning of June actually for PCOS. I already take 1500 of Metformin and exercise 5 days a week. At first, I had horrible nausea and diarrhea, but as of the beginning of July, I feel normal. It curbs my cravings and suppresses my appetite. At first, I was barely eating, almost starving, but now I can eat a normal amount. I’ve lost 15 pounds in a month and am very happy with my results so far. Just started the 7 mg today, excited to see how it goes."

• boo...
• Taken for 1 to 6 months
• July 15, 2022

Semaglutide for Cardiovascular Risk Reduction "Working with a board-certified obesity physician who suggested I try Ozempic. I am not diabetic but was pre-diabetic in 2015 and was on 1,000 mg Metformin until February of this year. I LOVE Ozempic. I feel like a normal human who doesn't think about food constantly, who can now leave food on my plate (because of Ozempic) and not pick at other people's plates. I've lost 32 pounds in 19 weeks!! I never had any gastrointestinal problems with the exception of being constipated, so I take something for that a couple of times a week. It is much better than the diarrhea I had with Metformin. I started on .025 mg for the first four weeks, then went to .05 mg and plan to stay on that as long as it works. BUT PLEASE BE AWARE, you have to cut down on carbs like breads, pastas, and sweets. I don't have a craving for sweets anymore. My doctor said Ozempic doesn't work as well if you keep eating those kinds of carbs, and I have noticed that when I cheat. I'm 74, something about 'old dog new tricks'"

• In ...
• Taken for 1 to 6 months
• June 7, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "6-7-2022: I am about to start my eighth week on Wegovy: first four weeks at 0.25 mg, second four weeks at 0.5 mg, and starting 1.0 mg this week if I can get the medicine. My pharmacy is having difficulty getting it. The first week was difficult. I started on a Thursday evening and had diarrhea for two days straight and accompanying upset stomach. I took Friday off from work and was sick on Saturday. On Sunday, I felt better but very tired and stayed in bed all day. I was feeling better by Monday and Tuesday. Since then, few side effects. I lost 5 lbs. the first month and 7 the second, averaging my doctor's goal of 6 lbs./week. I'm so glad to be moving in the right direction. I'm 5'2" and weighed 260 at my highest. I lost 30 pounds a couple of years before COVID hit and had kept it off (a major triumph) but had gained back 10 of those pounds before starting Wegovy."

• Non...
• Taken for 1 to 6 months
• May 15, 2022

For Weight Loss (Obesity/Overweight) "I started using this as a last effort to lose weight. I had tried everything I knew to do. My doctor starts out with a very low dose (0.10) and takes it up each week (0.20, 0.30, etc.). I experienced a little nausea my first week but severe nausea my second week. She just kept me at 0.20 for 2 weeks until I was no longer feeling that. I am now at 0.30, not because of nausea but because it is working so well at that dosage. I have had constipation for several days and then diarrhea for a couple of hours, but I am eating so little that I don’t have much in me. I am drinking a lot of water (always have) and haven’t experienced tiredness or fatigue. In the first 5 weeks, I lost 11 lbs. and 5 1/2 inches. I’m really happy so far. I never thought they would make anything that helped me. I do eat, just very small amounts. I do get a small rash at the injection site, but I use Benadryl cream and it slowly goes away."