Semaglutide and Tiredness: What Users Say

• Mar...
• May 26, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "This is a miracle pen, started on 5/22 155 lbs today 5/26 150 lbs. No side effects except the day I took the shot, got very tired in the afternoon. Eating protein shakes, not hungry at all. Hopefully, my insurance continues to pay for it!"

• Ano...
• Taken for less than 1 month
• April 26, 2025

Semaglutide "Incredible that one's appetite just vanishes. Sadly, the side effects are quite dramatic. Nausea, burping, tiredness. Not such a good combination."

• Ted...
• Taken for 1 to 6 months
• February 12, 2025

For Weight Loss (Obesity/Overweight) "This drug has definitely helped with decreasing my appetite and decreasing sugar cravings. I've been on semaglutide for 6 weeks and have lost 13 lbs so far. As far as side effects go, I've experienced some tiredness, nausea, and some stomach discomfort. Nothing debilitating. I'm going through a weight loss center. I go once a week for counseling and injections. I started out at 0.25 injection the first 30 days and am now up to 0.5 injections once a week."

• Kat...
• Taken for 2 to 5 years
• October 10, 2024

Semaglutide for Type 2 Diabetes "I have been on Ozempic for Type 2 diabetes. Was overweight as well, I am 4'11 and had ballooned to over 170 pounds. I was taking medicine for blood pressure, anxiety, depression, you know, all the things. I started in March 2022. My A1c was 7.9. Today I am down to 105 (hold up, that is normal for my height). No more high pressure. Beginning, I wasn't sure I would get past the nausea, but I fought through it, and yes, it does go away. I have been on stool softeners for a while, so I have never had any issues going to the restroom. My A1c is 5.4 now. I don't feel good, though. I can't put my finger on it, but I am severely exhausted and fatigued. I will not trash this medicine because I think it works as it should and has been amazing for diabetics. I just wish I didn't feel like poo all the time. The side effects do subside over time. My doctor and I have found the perfect dosing and schedule for me to keep my blood sugar under control."

• BHW...
• Taken for less than 1 month
• September 23, 2024

For Weight Loss (Obesity/Overweight) "I began taking the 0.25 dose 4 weeks ago (I will take my first dose of 0.5 this upcoming week). I was VERY hesitant to begin this journey due to the reviews I have read regarding side effects, but I am fortunate enough to not have experienced many. I can say I was a bit lethargic the first few days, and I do experience mild nausea if I do not eat. Prior to taking this drug, I was constantly hungry, and the food noise I experienced was constant - it regularly affected my daily functioning. However, about 48 hours after taking the first dose, I began to notice a difference. I legitimately have not experienced the sensation of hunger in 4 weeks, which is a GAME changer for me. I have not made any drastic changes to my diet or exercise, as I was already eating quite healthy and working out 3-6 days a week. I have lost 16 lbs - will update on my journey in a month or two."

• Dut...
• Taken for 1 to 6 months
• September 6, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "I'm almost 2 meters long, and when I started, I was more than 157 kg. Within 11 weeks, I lost 22 kg. Almost every week, I lost 1.5 kg and more after the big water loss. For me, it's an addition to the bigger plan. Yes, I use Wegovy (now on 1 mg), but I also go to the gym 5 times a week and add some hour-long walks to my day. And yes, I also have a strict timeframe where I have my meals. And yes, they are mostly veggies and some yogurt with some granola for some fiber. I had some side effects like heartburn, burping, constipation, and I'm more tired than before. But I think that's a normal thing to process, especially when you make the transition. If you are seriously overweight, please consider this medicine as a small part of the bigger plan!"

• jos...
• Taken for less than 1 month
• September 2, 2024

Semaglutide for Type 2 Diabetes "Scared of taking any medications. Thus far, it has been dropping my numbers, however, I have been waking up and having difficulty falling back asleep. I am a bit tired during the day. Thus far, it looks like it is working."

• mar...
• Taken for 1 to 6 months
• July 4, 2024

Semaglutide for Type 2 Diabetes "So far, so good. I have had to decrease my insulin from 44 units to 22 units and stopped 500 metformin. Lost 10 lbs in the first 1 1/2 weeks, then plateaued, now weight is dropping again (4 lbs). I've been on it for 4 weeks and will increase to 0.5 on the next shot day. Got the prescription from my doctor and will see him 3 months from starting Ozempic. Really watching what I eat. Only side effect so far is feeling tired a lot, but I can live with that. Oh, and I am 71 years old and obese with a body mass index of 49. Ouch, I know."

• Han...
• Taken for 1 to 6 months
• June 18, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I need to lose weight. I have lost 25 pounds in three months with this medication. Worst side effects I have experienced are occasional headache, constant tiredness, and I am cold in the afternoons. I’m on the 1.7 mg starting today."

• Daw...
• Taken for less than 1 month
• May 24, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Just started this new medication, and I’m on my second injection of the .25 mg. The side effects I have had are slight abdominal pain, acid reflux, nausea, and tiredness. I am 5’8 and was 244.5 lbs. To date, I am now 239 lbs - I’ve lost 6 lbs since 5-21-23. I weigh in every Sunday to stay on track of my weight and what it is. The side effects are mild, and I am going to stick with it because, like so many others, I’m tired of being TIRED… the weight has to go, and I encourage you to try this."

• Gra...
• Taken for 1 to 2 years
• May 21, 2023

Semaglutide for Type 2 Diabetes "Have been on Ozempic for 2 years. It's fantastic for weight loss and improving BSLs and HbA1c level, but I ended up with hyperthyroid. I feel really exhausted all the time, have frequent migraines with aura, daily dizzy spells, muscle pain with spasms, and changes of all over body skin texture. I used to have really great skin, but it’s dry and rough now. I’m glad my diabetes is under great control, but the side effects can be pretty brutal."

• Bac...
• Taken for 1 to 6 months
• March 9, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy 6 weeks ago at 0.25 mg for 4 weeks, and for the last 2 weeks at 1 mg. I started at 211 lbs and am now 197 lbs, so have lost 14 lbs and counting in 6 weeks. Not bad! Symptoms I've experienced include being slightly more tired than usual on the day of the injection, and some constipation at first but I use Miralax if there's an issue and it works fine for me. I haven't had any extreme nausea, but the injection definitely makes me less hungry and there are certain foods that I feel slightly queasy even considering eating-like high-fat foods-so I don't eat them. I eat a lot more fruits and vegetables and get full very quickly. I work out 4-5 days a week, my energy has been good and I feel like I'm getting back to my old self. I'd like to be about 135 lbs eventually. Wegovy has been a lifesaver. I'm 55 years old and had considerable cravings, especially at night. I'm happy to be free of them. I hope to make my new habits permanent."

• Ext...
• Taken for 1 to 6 months
• January 18, 2023

For Weight Loss (Obesity/Overweight) "I took my first injection on Dec 17, 2022, so I'm 4 1/2 weeks in (1 month). I'm on the 2.4 mg injection. Started at 30 units. Lost 9 lbs the first week. Gained weight the following weekend over Christmas, and also a bit over New Year's weekend. As of this morning, I'm down from 238.6 lbs to 218.4 lbs...that's 20 pounds in a month, including the weight I had to lose twice from gaining over the holiday weekends! I take my injections on Saturday. Side effects: nausea on Sunday, very, very light. Enough to notice, but not uncomfortable. Tired on Monday mornings. Take B12 and fine in a couple of hours. A little bit more tired on Tuesday mornings. Again, B12 and fine. Feel good on Wednesdays. Thursday, I have an abundance of energy. Friday afternoons, I can feel the rumblings of hunger, but don't really feel like eating. Saturday, it's time for the injection again, so the rumbling stops. I haven't experienced any other side effects."

• In ...
• Taken for 1 to 6 months
• June 7, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "6-7-2022: I am about to start my eighth week on Wegovy: first four weeks at 0.25 mg, second four weeks at 0.5 mg, and starting 1.0 mg this week if I can get the medicine. My pharmacy is having difficulty getting it. The first week was difficult. I started on a Thursday evening and had diarrhea for two days straight and accompanying upset stomach. I took Friday off from work and was sick on Saturday. On Sunday, I felt better but very tired and stayed in bed all day. I was feeling better by Monday and Tuesday. Since then, few side effects. I lost 5 lbs. the first month and 7 the second, averaging my doctor's goal of 6 lbs./week. I'm so glad to be moving in the right direction. I'm 5'2" and weighed 260 at my highest. I lost 30 pounds a couple of years before COVID hit and had kept it off (a major triumph) but had gained back 10 of those pounds before starting Wegovy."

• Lad...
• Taken for less than 1 month
• February 19, 2022

Semaglutide for Cardiovascular Risk Reduction "Went to my endo, desperate from dealing with both hypothyroidism and menopause. Have regularly put on 30 kg over the past 5 years up to 114 kg, have extreme fatigue, spine issues, and severe leg pain/body aches. Was prescribed Ozempic to assist with weight loss as nothing else worked. I was very worried about side effects and it not working after reading reviews. Started my 0.25 mg dose 3 days ago, injecting in the upper thigh just before bed, but didn't get the full dose as I pulled it out a tad early. Had some mild nausea the next morning that only lasted a few minutes and developed a headache, but panadol took care of that. I didn't notice much the first day and was worried that it wasn't going to work. However, on day 2, I was only able to eat about 1/3 of my dinner and felt full. Have already lost 0.5 kg in just 3 days. No other side effects that I can tell. Though I do feel more thirsty and am a bit tired; however, that's normal for me, so can't say it's a side effect. Happy so far!"

• Ano...
• Taken for 1 to 6 months
• January 31, 2022

Semaglutide for Cardiovascular Risk Reduction "I have tried so many types of diets, shakes, personal fitness training, you name it, and weight did not budge. Since starting on Ozempic at the end of November 21, I have lost 10 kg over 2 months and counting. I started on 0.25 mg and have progressively moved on to 1 mg (which I have been on for 2 weeks). Besides some tiredness, I have had no side effects. It is easy to use, and the fine needle is painless. So happy!!"

• LMH...
• Taken for less than 1 month
• November 8, 2021

Semaglutide for Weight Loss (Obesity/Overweight) "So far so good. I'm only on week 2, but am down 10 pounds with a combination of exercise and a 1200 cal/day diet. The symptoms I've had so far are tiredness, constipation, and some hair falling out (Dr. will be checking my vitamin levels to make sure I don't need supplements with the new diet). It definitely curbs my appetite, which is huge with my diet essentially cut in half. I am looking forward to seeing sustained results."

• AJa...
• July 4, 2021

Semaglutide for Type 2 Diabetes "I have been taking 3 mg Rybelsus since June 4th. I am not experiencing nausea nor diarrhea, however, I am experiencing constipation and loss of appetite. Since I have been taking this medication, I notice I get tired very quickly. Overall, I notice that it has helped my diabetes tremendously, and I have lost 8 lbs with very little exercise. I also take metformin 750 ER. Before starting Rybelsus, my A1C was 8.1, I do expect it to be much lower on my next visit in September."

• Mis...
• Taken for 6 months to 1 year
• August 14, 2020

Semaglutide for Type 2 Diabetes "Started Rybelsus when it first came out in October 2019. Took 3 mg at first and my glucose levels started to rise. Changed to 14 mg and was on that for 6 months. Glucose went very low - I was tired and weak. A1C went from 10.1 to 5.2. Changed to 7 mg and feel so much better, glucose levels are still within normal limits. I've had no side effects and great results. I do take this with 5 mg of Glipizide - once a day. Have tried many diabetic drugs and Rybelsus has worked the best. I've had a slight weight loss... under 10 lbs. So glad I tried this drug. It's a winner in my book."

• Los...
• March 3, 2020

Semaglutide for Type 2 Diabetes "I have taken Ozempic for four days and have not experienced any of the symptoms others are saying they have had with one exception: I am very tired. I am eating a little less but do not feel like some say they can't eat at all. My blood sugar is down to 110, and I have lost three pounds. So far I see only good things. I hope it stays that way as I want to lose about 30 pounds and not take metformin. Hopeful!"

• Pat...
• July 19, 2019

Semaglutide for Type 2 Diabetes "Started taking Ozempic for pre-diabetes and insulin resistance. This is the first medication I've ever taken for diabetes. A1c was 5.7. I increased the dose quickly at the doctor's recommendation if little to no side effects occurred. First dose 0.25 in the office. Second 0.5 a week later. Third dose at 1.0 a week after that. Only side effect I have is mild nausea. Appetite has disappeared, and I eat only when hungry and much smaller portions. Serious bloating when I eat too much, which is a great deterrent. Been on the medication for 4 weeks overall, 2 weeks at 1.0, weight dropped from 305 lbs. to 295 lbs. Still a little lethargic, but I was very lethargic before starting the medication. I feel like this medicine is a game changer for me. I love not thinking about food all of the time, only eating when hungry and not for pleasure, and losing weight. Will retest A1c in 2 months. Hopefully, the weight loss continues, and I caught the A1c level before it turns into full-blown diabetes."

• VDC...
• Taken for less than 1 month
• June 30, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I am super tired after the 3rd day, hoping it stops. Also, I can't eat much of anything. More like snacking is all I can do right now. No way I could eat a full meal. 1/4 of a sandwich puts my belly on 100% full. Hope this is normal. Thx."

• Mae...
• Taken for 1 to 6 months
• June 26, 2025

"Constant headache, tiredness, lack of energy. I didn’t want to go out or do anything with family or friends, but mainly because I had constant headaches that were not being relieved by my prescription medicine."

• Anonymous
• Taken for 1 to 2 years
• March 10, 2025

Semaglutide for Type 2 Diabetes "Pros: Blood sugar and weight became stable. Cons: However, after 18 months of taking a .5 dose, I feel tired and weak all the time, even though I am active and walk 3 miles four days per week. Plan: wean off Ozempic gradually to see if my energy returns once my system is cleared of the drug. Recommend: depends on the severity of Type 2 and whether a person has the knowledge and ability to control illness with diet and lifestyle, which is what I plan to do."

• Apr...
• Taken for 1 to 2 years
• December 31, 2024

For Weight Loss (Obesity/Overweight) "I took a very low dosage of .25, and I lost 30 pounds over the course of six months. The first few days of taking it, I would have a headache and would be very tired, but that eventually went away."