Semaglutide and Vomiting: What Users Say

• RAM...
• Taken for 1 to 6 months
• May 28, 2025

Semaglutide for Type 2 Diabetes "I've been taking Ozempic since the beginning of March 2025. My starting dose was 0.25 and I am now at 1.0. At the time I started, I weighed about 193 and am now weighing 156 lbs. The only side effects I seem to be dealing with and do not like are nausea, vomiting, and constipation. Ozempic has curbed my appetite considerably, as well as my liquid intake, which I don't mind since I've lost a lot of my weight. Right now, my biggest problem is finding clothes to fit me and deciding if I should keep my old clothes or donate them. I really haven't bought much in the way of new clothes in part because I don't know how much more weight I am going to lose, plus the expense of buying new clothes. My goal is to weigh somewhere between 135 and 140. My A1c is down from 8.9 to 8.1, I would like that to be lower, like 7.1."

• MJo...
• Taken for 1 to 6 months
• March 25, 2025

Semaglutide for Type 2 Diabetes "I took it for 3 months and was sick 2 days a week, so I stopped, but I lost 40 lbs. So I want to try again. I took my shot yesterday and have thrown up 5 times today. I want to lose more weight, but I can't stand being sick. What can I do?"

• Sus...
• Taken for 1 to 6 months
• February 19, 2025

Semaglutide for Cardiovascular Risk Reduction "Ozempic gave me unbelievable diarrhea and I vomited on my baby more than she vomited on me. However, I have lost 24 kg in just a few weeks."

• Fur...
• Taken for 1 to 6 months
• December 22, 2024

Semaglutide for Type 2 Diabetes "I have been taking Ozempic for 9 weeks. Started at 0.25 for 4 weeks, and then my dosage was increased to 0.50 for 4 more weeks. Last week, my dosage was increased to 1 mg, and now I am feeling nauseous and have been vomiting. I have to eat very small meals, or I throw it all up. Sometimes I am throwing up from the night before. I don't know what my A1c is currently, I have labs next month. My A1c was progressively going up, and I couldn't get it down. Will push through these side effects and see what happens."

• Jul...
• Taken for 1 to 6 months
• November 19, 2024

Semaglutide for Type 2 Diabetes "It is helping me lose weight, but very slowly. I am experiencing a lot of nausea and vomiting, and headaches, and my stomach is not feeling good. I am on a 0.5 dosage a week."

• Dre...
• Taken for 1 to 6 months
• September 26, 2024

For Cardiovascular Risk Reduction "Very good on the smaller doses 0.25 then 0.5 mL. Lost 25 kg in 4 months. I started taking 1 mL, and I am suffering from severe stomach pains, dizziness, and vomiting. Will go back to 0.5 mL, where I lost the weight and very little side effects."

• Anonymous
• Taken for 6 months to 1 year
• September 16, 2024

Semaglutide "I was a 59-year-old woman, and at 5'4" tall, I weighed 212 lbs. My knees had been replaced a couple of years ago, as well as back and foot surgery. I was in constant pain and miserable. Eight months later, I am proud to say I am at 159 and stalled out. I need to get out and walk more, and that'll help. I am not overeating or eating junk... it just stalls out on occasion. I feel SO much better! I move with ease and don't groan getting up from my chair! The day after my weekly shot, I do get nauseated. On occasion, I will vomit. It's not terrible, and it is well worth it!"

• Jan...
• Taken for 1 to 6 months
• September 12, 2024

For Weight Loss (Obesity/Overweight) "The first month was great, weight loss of 14 lbs. Felt fine. But the 5th week increased injection to 2, the fourth day I had terrible stomach pain, diarrhea, vomiting, got better but still have heartburn, burping, and unable to go to the bathroom. I take omeprazole and Peptic as I have GERD! But has not helped! Tried Pepto-Bismol, doesn’t help!"

• art...
• Taken for 6 months to 1 year
• September 11, 2024

Semaglutide for Type 2 Diabetes "It has helped lower my sugar level. It has also helped lower my weight by 15 pounds. I threw up once when I went to the .5 mg dose. I am now taking 1 mg without any side effects."

• Che...
• Taken for 1 to 2 years
• September 7, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "I sat out on a journey to lose weight in January 2023. I am a heart patient, and I was weighing 220 lbs for the first time in my life. I started in the beginning, I had lots of nausea and vomiting as I went through the different doses. It wasn’t until I got to the highest dose that I really saw the change in my body weight. The weight just slid off. I lost a total of 100 lbs. I definitely changed my diet: high protein, grilled veggies, and fruit. I will say it changed my taste buds. Salty things were overwhelming to me while on Wegovy, and so was sugar. I can’t eat cheese at all without getting sick. But I feel better. My heart is doing well, and my lipids are finally in the normal range. This medication helped save my life, and I feel so blessed. Good luck on your new journey, and don’t be afraid to ask your doctor for nausea meds, it helps a lot."

• weg...
• Taken for 1 to 6 months
• July 26, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I gained 70 pounds during the pandemic. December 2019, I was 138 pounds standing at 5'3. Then in January 2021, I was 209. I started having back pain and foot pain from the weight. I tried dieting, but I am a single mom that doesn't have time to cook healthy every night, and I work around food, so I told my doctor he has to prescribe me something to lose weight. He saw it was taking a toll on my health as well, so he started me on .25 Wegovy injections. I lost 13 pounds my first month. I had nausea once or twice, nothing I couldn't handle, and I vomited only once. I even had more energy. Then he prescribed me the .5 the next month, but pharmacies all in a 30-mile radius were on backorder for the entire summer with no hopes of getting it in until the end of September. I kept being persistent with the pharmacist, and she said, have your doctor call me, he can up your milligram, and we can get that dose in 2 days, so at this point, I was desperate and starting to gain back the 13 pounds I lost. So I was upped to 1.7. OMG"

• Anonymous
• Taken for 1 to 6 months
• May 18, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I have nausea and vomiting, however, my HBA1C has gone down significantly, and at this point, the side effects are worth my DM numbers being normal!"

• cyn...
• April 21, 2023

Semaglutide for Type 2 Diabetes "I had immediate appetite suppression and decreased blood sugar. On the second day, vomiting, gas, and felt full."

• Kri...
• Taken for less than 1 month
• January 8, 2023

Semaglutide for Cardiovascular Risk Reduction "Just took my 2nd dose. When I started last week, I did have some nausea, and I did vomit once, but I had eaten quite a bit at dinner before I took it. I injected in the thigh. After that first night, everything settled down, and I feel great. I have MS, and for some reason, I am seeing quite a change in my symptoms for the better. I have GERD and take 40 mg of omeprazole and 20 mg of Pepcid. These drugs have really helped with nausea. My doctor said this is what he would prescribe to other patients he had put on Ozempic. I am down 5 pounds this week. You don’t get hungry at all, so make sure you have some small meals throughout the day so you get your proper nutrition and vitamins. Just this week alone, I have noticed my cravings have stopped for sweets and junk food."

• Scu...
• Taken for 1 to 6 months
• November 22, 2022

Semaglutide for Type 2 Diabetes "A little nausea in the beginning and two episodes of vomiting in the first several weeks. After 3 months, I’ve lost 17 lbs, my A1C is down from 7 to 6.1, and my cholesterol is down a lot. I feel great."

• Fin...
• Taken for 1 to 6 months
• July 5, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "57-year-old on this for 3 1/2 weeks. I'd like to tell you how much I lost (was 4 pounds at 3 weeks), but I am so constipated for 4 days I cannot be sure what my real weight is (it could be 6 pounds now). Get a telemedicine provider to send you a vial of semaglutide (not the pre-loaded syringes) and use an insulin syringe to administer 1/2 the dose on one day with an ODT Zofran, then take the second half of the dose 24 hours later with another ODT Zofran. I administer in my outer thigh, like you would give insulin. The provider will tell you exactly how many 'units' to administer per week, just cut it in half, say Saturday and Sunday. Take a stool softener on Sunday, which I forgot to do this week! I have had zero gastrointestinal issues, no nausea, no vomiting. The Zofran may be causing some of the constipation, and I don't consider this a real issue, just a minor side effect with an easy fix. I am a Nurse Practitioner, so I have been watching everything for real side effects. I'll update."

• Anonymous
• Taken for 1 to 6 months
• May 6, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "Ok, so it's been 2.5 months. I made it to the 1 mg dose and had to stop. I did fine with the 0.25 and 0.5 doses and lost weight. The trouble started when I hit the 1 mg dose. I felt horrible the first week, like absolute death, with side effects of nausea, diarrhea, abdominal pain-just awful. I reached out to my MD, and she said this was normal to go ahead and keep going. The second week on this hasn't been much better, with vomiting, and I'm stopping it myself. I have lost 20 lbs the last couple of months even on the lower doses, but due to supply chain issues, my pharmacy cannot get them in, so I'm having to switch medications now. Lower doses have way less side effects and are just as effective. I wish I could've continued with it."

• 510...
• Taken for 1 to 6 months
• April 12, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I'm on my third month of Wegovy. The day after my injection, I usually puke at least once and sleep 10+ hours with extreme fatigue and nausea. I started in February 2022, and now it's April 2022. I went from 247 lbs to 222 lbs. 25 pounds. I get ill if I eat sugary foods with this. I eat three small meals a day, a plant-based diet, with around 5,000 steps a day and little to no exercise outside of work. I felt good usually a couple of days after injections, and by the third week at the same dose, I had no side effects. The first two injections at a new dose aren't easy for me. I have missed work and had a hard time watching my two-year-old due to puking and fatigue. I gave 10 stars because it does as it says with side effects you are aware of to begin with."

• car...
• Taken for 1 to 6 months
• February 21, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I have been on Wegovy since October 2021. I'm currently on 2.4. I have lost a total of 35 pounds. I have a lot of constipation, I have to take something for the constipation. I do have some vomiting when I eat hot, spicy, or greasy food. I'm very pleased with Wegovy."

• Ddd...
• Taken for 1 to 6 months
• February 11, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I have been on this medication since August 2021. So far, I have lost 36 lbs. I have been on the max dose of 2.4 for going on 2 months now. Side effects I have experienced have been sulfur burps/gas, nausea, vomiting, diarrhea, and sensitivity on my back and scalp (sunburn-type feeling). Although I haven’t had the most pleasant side effects, I would still recommend this medication. Now that my body is used to it and I am up to the max dose, I haven’t had any of the side effects lately, besides occasional nausea. I have noticed the most weight loss on the 1.7 and 2.4 doses. Just this week alone, I have lost 5 lbs. I hope to keep losing at this rate. I am only 40 lbs away from my goal weight now. So far, I have not really changed much with my diet or exercise. I cook my meals at home, drink water, and walk a few miles a week, and that is it. If you can stick it out and get up to the maintenance dose, it gets better!"

• Hop...
• Taken for 1 to 6 months
• January 7, 2022

Semaglutide "I've been on Rybelsus for about 6 weeks now and am up to the 7 mg dose. I was placed on it to help lose PCOS-induced weight gain. It took about a month to get used to (minor vomiting, nausea, constipation, and diarrhea during the adjustment). I've lost almost 15 lbs, my anxiety levels have plummeted, and my skin is the clearest it's been in ages. I no longer have sugar or processed carb cravings, which I think is helping all of this. I'm lucky that my insurance is fully covering the medication since it is pricey."

• Jen...
• November 24, 2021

Semaglutide for Cardiovascular Risk Reduction "Stay away from beef! It's a game changer. I have lost 43 lbs over 4 months. It really works for me. I am at 1 mg/week now, and I feel full constantly. I eat around 1/4 of what I usually did, and my sweet tooth is a lot less than it used to be. I had a lot of side effects with sulfur burps, diarrhea, and vomiting at the beginning. I found a 100% correlation with eating beef and the nasty side effects. Even as little as 1 oz! I had been feeling fine for a month when I last week tried 1 bite of a nice steak! 24 hours later, the terrible side effects were back, and I lost 5 lbs over 24 hours (mostly fluids). So stick to chicken and fish. I have not dared to test pork or lamb yet."

• Lee...
• Taken for less than 1 month
• November 22, 2021

Semaglutide for Cardiovascular Risk Reduction "I took my first injection a week ago. I've already lost 10 lbs but feel horrible. Headaches, dizziness, and feel like vomiting. I'm going to keep trying. I'm not a diabetic but was willing to try anything for weight loss. Any advice?"

• Kas...
• Taken for 1 to 6 months
• September 29, 2021

Semaglutide for Cardiovascular Risk Reduction "I have been on Ozempic for 3 months now, the first day I vomited but haven’t since, nausea for the first month or so, and I got very constipated, but now all is good and I suffer no side effects anymore. So far, I have lost 22 kg, I have no sugar cravings, and my appetite is right down, making sure I eat healthy meals is the only challenge as I do not feel like eating. But I could not recommend this enough to anyone who really struggles with food and weight loss."

• Kim...
• Taken for 6 months to 1 year
• August 2, 2021

Semaglutide for Type 2 Diabetes "I started Ozempic in October 2020. I have lowered my A1C from 8 to 5.8 and have, so far, lost 63 lbs! My appetite has decreased, but I'm eating and craving healthier food. I have continued to experience intermittent nausea and vomiting, but the side effects have significantly decreased. This is my miracle drug!"