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User Reviews for Lupron Depot to treat Endometriosis

Lupron Depot has an average rating of 5.5 out of 10 from a total of 112 ratings for the treatment of Endometriosis. 43% of those users who reviewed Lupron Depot reported a positive effect, while 37% reported a negative effect.

Lupron Depot Rating Summary

5.5/10 average rating

112 ratings from 113 user reviews.

Compare all 76 medications used in the treatment of Endometriosis.

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Reviews for Lupron Depot

Mimie February 28, 2021

“Straight after the injection I regret it because of the side effect but after 3-5 days it makes me feel better and it makes my life back. It has been 8 years that I have been in pain, 1 ectopic pregnancy and terrible pain every single period. To much medicine I had take and it is a risk to my kidney function and no medication help me at all. I just keep asking how come I only had this Lupron after 8 long years in suffering the terrible pain. It makes me feel better and be able to do the things that I never ever been doing for 8 years because 2-3 weeks in pain every period. Now I can do all the normal activities and it feel so good to be up in the morning after having a good sleep and pain free. I am looking forward for my second injection.”

9 / 10
Lash · Taken for 6 months to 1 year February 4, 2021

“I've been suffering from endometriosis and ovarian cysts for 22 years. After trying all the hormones, we discovered I also had fibroids and adenomyosis. My doctor performed a hysterectomy with RSO. Even with that, I kept having cyclical bleeding and endo pain. We agreed on starting lupron depot for 6 months with progesterone add-back. I was incredibly nervous because of all the reviews. The first 2-3 weeks were pretty rough. Migraines, emotions all over the place. By week 4, I felt amazing! As the first 3 month shot started to wear off, symptoms began returning and I couldn't wait for the next round. Dose #2 is coming to an end and I can confidently say I haven't ever felt better. This drug was a dream come true for me! We've decided to proceed with removing the last ovary and, hopefully, I can start truly living life.”

10 / 10
Miso907 · Taken for 1 to 6 months January 7, 2021

“After a laparoscopic surgery and an 84 day heavy, heavy period, I started Lupron. The first two weeks were not great. My bleeding stopped and then started again but it was more like an ordinary period. I saw an increase in migraines during these first two weeks but I saw a significant reduction in migraines after that. I have zero complaints about the intervening 10 weeks. I’ve been period free, pain free, side effect free. I can’t remember the last time I felt that good. I’m due for another three-month injection in a week. In the last couple of days, I’ve started to have cramps and daily migraines. I’m very much looking forward to getting another dose!”

10 / 10

Frequently asked questions

Jensey37 · Taken for 1 to 6 months February 13, 2020

“I feel like I’m one of the few people who has had a POSITIVE experience on the medicine Lupron . I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine are minor hot flashes!! I can’t believe it. This medicine has been a blessing.”

10 / 10
Sarah2016 January 2, 2016

“Don't let the online reviews cheat you out of a better life! I actually delayed getting Lupron by a year because I was so scared by the online reviews and reports of adverse reactions/symptoms. However, my experience was wonderful. My doctor put me on the ad-back and I did have a FEW hot flashes initially, but I would take those 1,000x over the pain my endometriosis caused me. I also took calcium to offset any bone density loss. Please, Please, Please work with your doctor to decide if Lupron is right for YOU. I did it and now I am on my way to restoring my quality of life.”

9 / 10
Lindz · Taken for less than 1 month September 30, 2018

“I’m a 24-year-old female who’s suffered from terrible endometriosis pain; my periods left me crumpled up on the ground, moaning in pain, to the point that I seriously wished I were dead. I am not exaggerating in the slightest. Sometimes I’d get really dizzy and hear an intense buzzing in my ears, right before I almost passed out. The pain was unbearable; I often had to miss school and work because of my period. I recently underwent surgery and was recommended Lupron. I read horrible reviews about it for weeks leading up to my doctor appointment and was terrified to try it, but so far I haven’t had any problems other than hot flashes (and that’s MUCH preferable to the agonizing pain I used to be in). Of course, it’s only been a few months since I got the injection, so we’ll see...but so far it’s been great! Don’t let the reviews scare you; if you’re in good health like I am, you probably won’t experience serious complications or side effects. Hope this helps!”

8 / 10
MoMoMo · Taken for 1 to 6 months May 6, 2020

“I was put on lupron depot for three months for endometriosis. I received an injection every month. My treatment started in January and ended the first Saturday in March 2020. The side effects weren't all that bad. I got my period on my dose but it eventually went after that. I had however severe headaches that made me dizzy, experienced some mood changes (mostly anger), painless sex, hot flashes (manageable) and joint pains at the end of my last shot. The joint pains are mostly in my knees and fingers but i only experience those after waking from a nap. Once I get up and start moving about they disappear. I now await my cycle to return. It has been 8 eight weeks since my last injection and signs of my period returning are back. I'm spotting and experiencing mild cramps. All in all my experience wasn't bad. Hope this helped someone oxoxox”

8 / 10

More FAQ

Ambear November 2, 2015

“I have been taking this for 6 months now, about to start my 7th and I love it! I will say the first month or so, I was really wondering what had I gotten myself into. But now, I am so glad I did it. I take the 1 a month not the 3 months shot. I haven't had a period in 5 months, I haven't cramped in 5 months. I was having hot flashes before I started taking this and I will say that at times they are way worse but I would much rather deal with hot flashes then be huddled over in my bed bc the cramps are so bad that I can't even function. I do understand that some people have bad experiences with things and some people don't It is all up to your body. Everyone's body is different. I hope seeing a good review like this will help.”

10 / 10
Teeellejay · Taken for 1 to 6 months February 10, 2020

“The depo has been great for me! At the end of my 3 month shot and the only major side effect I have are the hot flashes (which are controllable). I haven’t had a period, haven’t been moody, minimal weight gain!”

9 / 10
Kris February 18, 2020

“Ok y’all I admit before taking Lupron Depot 11.25 Mg 3 month injection; I read every review I could find. I was disappointed to find mainly negative reviews but I took a leap of faith and decided to get the injection anyway. Within the first month I truly regret that decision. In tough situations I typically look for the silver lining. However I was not prepared for the extreme fatigue (No more 5am workouts), hot flashes all day every day, night sweats that literally leave my side of the bed soaked (it’s totally gross), but the topper is body aching and hurting down to my muscles and bones like I have the flu...every day going on 63 days straight. I am 38 yrs old, good shape, active when I started the injection I was 115lbs, I am now 130lbs with no energy. Needless to say I am declining the 2nd treatment and look forward to 2-6 months when all of the side effects should fully wear off and hopefully get my normal life back.”

3 / 10
Minddestroyer · Taken for 1 to 6 months January 28, 2020

“I had 2 injections of this ruinous dangerous drug - Lupron! 1. NEVER use if have PMDD or PMS! Thyroid disease. Or serious mental issues after child birth aka manic depression. My gracious Dr by passed all the contraindications!! I have spent the past 26 years in an unimaginable state of severe fear! I was diagnosed with hypothalamus, adrenal, and digestive exhaustion. I had to have food supplements to survive! This drug will ruin your MIND! Get a hysterectomy instead!!! It can't cure endometriosis!!!! Get on bio identical hormones after wards! You'll be feeling BETTER WITHOUT uterus, and be able to go on! PLEASE PLEASE do NOT let ANYONE talk you into using this brain altering destroyer! You will NEVER have your full sanity!”

1 / 10
LJonesL December 15, 2014

“I was diagnosed with Stage 4 endometriosis and was prescribed Lupron. After reading all of the horrible reviews and side effects I was terrified to try this. After chatting with my doctor we both agreed that this would be the most aggressive treatment as my husband and I would like to get pregnant one day. I am on month 3 of the shot and I have to say that I am pleased. The worst thing are the hot flashes. For me they are at least 10 times a day! But I will take that over the excessive cramping and pain any day. I feel minor cramps occasionally during the time I would normally have my period. I have experienced no depression, weight gain, weight loss, bleeding, joint pain etc. I am hoping after the treatments I will be able to conceive.”

7 / 10
Endo Stage 4 · Taken for 1 to 6 months September 24, 2014

“Stage 4 endometriosis. I've been on Lupron for 3 months and will get another injection next week. I've had a few hot flashes, about 1x/day occasionally, but not everyday. I have stayed below my original weight by about 5lb. Some moodiness/occasional depression. But overall I haven't had any major problems! I was very worried about side effects before starting Lupron, but am glad I did it. I want to be healthy! I'm getting married next weekend also so have been planning a wedding at the same time. We're hoping to get pregnant next year!”

10 / 10
amaya2 · Taken for 1 to 6 months November 19, 2012

“I started Lupron about a month ago. I started taking it after the doctor told me I had stage 1 endometriosis. About a year before I found out I had PCOS which caused me to gain a lot of weight, about 23lbs. Since I've been on Lupron I've been feeling so much better and I've LOST 7LBS!! The only thing I have been struggling with is the hot flashes. other than that I've been doing very well on the shot.”

10 / 10
1Sweet67 · Taken for less than 1 month January 29, 2014

“I was on Lupron for 6 months back in 09. The side effect weren't bad for me at first but I have to say the night sweats were the worst! I just hated waking up in the middle of the night, needing to shower because I was so sweaty. However, I was pain free! I had an AWESOME summer and went camping, mountain biking, traveling. My pain has slowly come back over the years and my (new) doctor just gave me my first shot of Lupron yesterday. I am hoping it works just as well as it did the first time. I want to be me again.”

7 / 10
cdawhg November 13, 2015

“I really feel it is important to share my experience with this drug. I did extensive research before making my decision to start the Lupeneta pack. I was scared and I prayed to have a good experience since most reviews for this drug are aweful. I am grateful to be able to give this drug TWO THUMBS UP! I am taking one month shots combined with the add back pills. The first month I experienced NO increase in symptoms. I bleed for the first month and a half, now my constant bleeding is gone! For the first month I experienced very mild hot flashes, now none at all. My quality of life is 110% better and I am pain free. I am so grateful i took a chance on this medication. I finally got a break from the constant pain and exhaustion from endo.”

10 / 10
Tired of this · Taken for 1 to 6 months February 17, 2019

“This made my pain much worse. It is the worst experience I've ever had with a medication! The side effects are much worse than the endo pain! This medicine shouldn't be given to women for endo! I have been in the worse pain and depression that I've ever had in my entire life thanks to this medication”

1 / 10
Not As Bad As I Thought · Taken for 1 to 6 months January 22, 2015

“I am 37 and for the most part been very healthy...never pregnant and married for three years. I have had ovarian cyst, but have been controllable. Nov.9, 2014 I went to the ER and the next day I was having a mass and 6" of my colon removed due to Endometriosis. I had stage 4. My OBGYN suggested this shot. I read all the reviews and was VERY learey of starting it, but I just took my second shot. It has not been so bad. I have experienced hot flashes and weight gain. I have about 4-6 hot flashes a night, but no sweats yet. I am hungry ALL the time and it seems the more I eat, the more I want. I cant seem to get full. I have gained 10 pounds in about 6 weeks.My mood has been good though. I have had to start Osphena due to side effects.”

10 / 10
Lexii October 5, 2015

“Don't do it! I got the 3 month shot 1 month ago and have had these symptoms so far: constant and severe pelvic pain, sharp lower back pain, pain when bladder is full and when emptying, lots of migraines & headaches, nausea, vomiting, high anxiety, extreme fatigue, very low mood swings, loss of appetite and insomnia. The worst symptom of all is the severe depression, I have had several thoughts of suicide. I would rather deal with just the pain than all of these together. I was told by my doctor the only symptom I would get is hot flashes and she had only heard of success stories with this drug, that was a total lie. If you react badly with other birth controls do not do Lupron, it's a living nightmare!”

1 / 10
Angel · Taken for 1 to 6 months February 28, 2018

“Hi, I was diagnosed with stage 4 endometriosis in April of 2017. My situation was a little different because the disease went into my colon and shut down my bowel system. After two surgeries my doctor recommended I go on Lupron for 6 months. After reading the reviews, I told my doctor no. I was scared out my mind. He insisted and I finally agreed. I just took my last shot of my 6mo treatment and in the beginning I experienced the hot flashes but I was given Northein pills to offset it and it worked. I didn't bleed, I occasionally had sweats, nausea or an upset stomach. However; I can't say anything really bad about the drug. I'm glad I took it. I think it depends on the individual body but I will say you have to give your system time to adapt to the drug.”

8 / 10
B January 20, 2020

“Lupron is a HORRIBLE medication. Many medical "professionals" are not forthcoming with their patients about all the side effects, or the long term side effects that continue well after Lupron is stopped. They also don't tell you it can kill you, or disable your life. This medication sent my life in a tailspin (of course I was lied too- being told all the positive, and common things you will find on any site about Lupron) I will never return back to normal. Just like so many others. I am now having to go for disability thanks to Lupron, and the negligence of of the doctor who gave It to me. Do IN DEPTH RESEARCH! Know your facts! I do not recommend this medication Not only does it damage your body in many ways, but it's put me into a living nightmare!”

1 / 10
Britt · Taken for 6 months to 1 year March 27, 2018

“Honestly I was so sick of having surgeries constantly and so my OB recommended me trying Lupron for my endometriosis - 1 shot once a month for 6 months and longer if i would like to. I was told I couldn't have any more babies. I had tried everything and nothing worked to have another. Got on lupron for my extreme pain from endo and for the first month I got a horrible period like period then after that I didn't have a period. When I got off it I was prego and didn't even know. I got my rainbow miracle baby thanks Lupron and my endo hasn't returned since then thank goodness. Yes hot flashes, being sick in the morning, tired a lot because I couldn't sleep and mood swings from hell was all worth it. I will definitely be back on this if my endo comes back!!!! Definitely a 10 star review from me! (I stayed on lupron for 9 months).”

10 / 10
Melissa September 27, 2018

“ I had severe cervical dysplasia requiring a portion of my cervix be removed, chronic pain, PCOS, and was diagnosed with severe endometriosis following laproscopic removal of many adhesions from my uterus and scarring of my ovaries. My OB recommended I do six to nine months of Depot lupron after my laproscopy to keep the Endo at bay and help reduce scarring. I started out with the one month shot and felt okay, a little achey and some hot flashes. I went back to got the three month shot. I was miserable but my OB really pushed me to keep going with it. I am on my second three month shot and I am not me anymore. I am moody, extremely depressed, my bones hurt, I've gained 20lbs, I'm fatigued, anxious, have insomnia, headaches, and have had horrible gastrointestinal symptoms. It is ruining my marriage. My work performance has suffered. I am foggy and forgetful. Everything is an effort. I will not be getting the last shot and hope this hasn't caused irreversible damage!!!”

1 / 10
Seelenlos · Taken for 1 to 6 months June 27, 2016

“I would like to address women who already struggle with depression, insomnia, or mood disorders, like myself. If you're already bad off don't do this to yourself, it might be the final "push". I got the 3month shot (+add-back) and it made me suicidal. My moods went from extreme anger to sobbing, insomnia, HOT FLASHES, and my left arm kept going numb in daily activities! This went on for a month, at 2 months I leveled out. Not far into the 3'rd month the hot flashes came back, cold sweats (felt like drug withdrawal), and my pain was back! I went to my Ob/gyn 1 week early because of this to find I had grown 11 new painful cysts! It didn't even work, and to stop it is also unpleasant (withdrawals). Worst med decision I ever made! HELL!”

1 / 10
Stephanie December 21, 2019

“I have stage 4 endometriosis and adenomyosis. Had emergency surgery 3 years ago due to a large endometrioma causing a total blockage of my sigmoid colon. Everyone's reports on here about unbearable pain and severe bleeding - yup, same for me. I've been bleeding nonstop for over a year now. Received my first 1 month dose of lupron on 11/22/19. The only side effect was a slight uptick in libido the first two weeks during the initial estrogen spike. The last week of the month, I got my period but the bleeding and pain were much reduced from before. Noticed an improvement in pain during intercourse. I am on the add-back and have had no night sweats, hot flashes, or vaginal dryness. No impact on my mood that I could notice. Received my second dose, the 3 month long dose, yesterday (12/20/19). Can't comment yet on the experience, but I'm sure hoping to stop bleeding entirely and eliminate the pain.”

9 / 10
23 year sufferer! · Taken for 1 to 6 months November 18, 2013

“I'm on day 48 of treatment and had my second shot on 11/04/2013. With the first shot I bled, 2 weeks prior and another 3 weeks after. After that I haven't bled since. I'm being treated for lifelong (23 years) Endometriosis. I have been disabled since 13 years old because of it. The only symptom I have had is SEVERE NON STOP hot flashes. I will have a hysterectomy in December.”

9 / 10
Rayvan June 25, 2015

“Worst mistake of my life!! I had one 3 month shot when I was 17 and I'm still regretting it (I'm 21 now). I was pretty much paralyzed while on it. I couldn't move on my own. I needed help to even sit up in bed. I missed so much school/work and cried almost all day every day. I was in so much more pain. I was constantly sick (vomiting, nausea, painful bowel movements, headaches, joint pains) and the menopause symptoms were absolutely crazy. I still to this day have stomach issues I didn't have before. I have bone density loss as well. I will never recommend this drug to any woman. It is not meant for us.”

1 / 10
usernametaken February 1, 2012

“I was actually on Lupron Depot for 18 months. My periods stopped within a week and my pain was gone within the first month. I almost didn't go on it because of the horror stories I read online, but I'm glad I did. My skin broke out more than normal, but nothing a little makeup couldn't hide. The hot flashes were intense at first, but slowly started to subside. After six months they completely stopped. I also fully understand night sweats. The side effects were well worth it to me since I no longer have cramps that hurt so bad I pass out. I am also enjoying being period free after never having a regular cycle and being anemic the better part of my life.”

10 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Endometriosis

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Symptoms and treatments

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