Lupron Depot for Endometriosis User Reviews (Page 3)

• Alm...
• November 13, 2011

"I have been receiving Lupron shots since August 2011. December will be shot number five. Within the first two weeks after receiving my first shot, I noticed a huge difference in pain. How awesome! I had been dealing with this pain since 2008. I had exploratory surgery and tried Chinese medicine along with acupuncture and found no relief. Lupron has been the first thing to help me be almost completely pain-free. Will post again after the 6th injection. I had one huge mood swing after my 1st shot and very little hot flashes. I am not craving chocolate as much but have found myself craving milk (I have always been a milk drinker)."

• Can...
• Taken for 1 to 6 months
• September 23, 2020

"Lupron ruined my health. It made me depressed and have suicidal thoughts, which are not normal for me at all. I did not continue after month 4, and unfortunately, because I wanted to stop the medication, my doctor would not see me anymore. Please research the ingredients and side effects before you choose to take Lupron. My doctor told me specifically not to look up the side effects... Not wise!"

• Sha...
• Taken for 6 months to 1 year
• September 20, 2019

"I had severe endometriosis. I had the kind of pain that makes you blackout. I would bleed all over my chair at work. I wear only black or navy pants. So far, I've taken 3 shots, and thankfully I am pain-free. I have no period. But the hot flashes are HORRIBLE. I'm always hot and tired. I don't remember the last time I had a good night's sleep. I've gone as far as putting ice packs on my bed so that I can sleep for a few hours. I've gained about 35 pounds in 9 months, my hair is thinning, I ache all over, my vision has decreased so much, I seem to forget everything if I don't write it down. I think I got the entire list of side effects, however, that pain before taking Lupron? No way! I literally shake when I think about it. I'll try to manage."

• Anonymous
• March 18, 2010

"I just had my 5th shot yesterday. The past few months have been painless in regard to side effects other than night sweats and mood swings. I have not gained any weight, and everything seems pretty normal. Once again, other than the mood swings. These are harsh, and sometimes I feel like another person has taken over my body and thoughts."

• Anonymous
• January 1, 2010

"I did a 6-month treatment of Lupron, and it wasn't that bad. The first couple of months, I experienced migraines and hot flashes. For the remainder of the treatment, I continued to experience the hot flashes, but my mood swings became very uncomfortable for my family, friends, and me. I would one minute be calm and neutral...the next minute I would become mean and hateful. That was never how I was prior to the treatment. However, I completed my treatment in August 2009, and I haven't had any problems with my endometriosis at all. My doctor has now given me the option to either get pregnant or continue with birth control pills until I decide to become pregnant to maintain the endometriosis. I highly recommend this method if you can withstand the side effects."

• Anonymous
• January 22, 2009

"I have taken monthly injections for the past 6 months. I had a very difficult time for the first 6 weeks of treatment, but since then have not had many side effects. I had severe stomach cramping initially, along with migraines and mood swings. As those side effects subsided, the hot flashes began. With the hot flashes came nausea and unpredictable crying fits. My doctor put me on a low dose of Estradiol and Prozac. Within a few days, I was pretty much back to my old self, minus the horrible belly pains. I have to say, overall the good outweighs the bad."

• End...
• August 26, 2015

"Lupron is not for everyone! I must admit I was horrified to try it, but it came to a point I would rather die, so I had nothing to lose. In 2011 and 2012, both 9 months each. Then after treatment was birth control (Levora), high dose. Now, 2015, just started having severe pain uncontrolled by anything else, so started Lupron injection yesterday. This med made me forget I had the disease. I'm not saying there could be long-term issues or anything else. But right now, in this moment, I'm not sick, and every time before, it was a godsend. Hopeful this time will be as smooth as the last couple of times. Good luck."

• Doi...
• December 1, 2016

"During my early 30s, I had 2 laparoscopies and 1 laparotomy for severe endometriosis but had no relief from pain. At 34, I had my 1st Lupron Depot shot. It eliminated my pain completely. The only side effects were hot flashes and irritability. The side effects were exactly what I am experiencing with menopause now at the age of 58. I did not have any joint pain or other side effects. After 6 months of shots, my primary care physician advised that bone loss could result from prolonged treatment, so we stopped treatment. As an alternative, I was put on low-dose birth control pills, which I took every day to stop my periods. Should have done this to begin with! No pain and no side effects!"

• Ei...
• December 7, 2016

"I have endometriosis and adenomyosis, and pain was scary, and I became bedridden some of the days. I had my first Lupron 11.25 mg in June 2016. I am suffering following side effects, but I will continue this medication as pain from endo and adeno is worse than side effects. - Swelling at feet - Weight gain - 6 kg in 6 months - Increased sweating - Hot flash suffered only the first month of this treatment - Fluid retention - Carpal tunnel - Forgetful - Growth of upper lip hair - Slipped disc and compression of the right leg nerves. I am going to take the second injection soon, and after that, I will go for hysterectomy. Btw, I am just 36 :(."

• Anonymous
• November 8, 2009

"I was very pleased with my Lupron experience. I was on a six-month course and found the first three to four months easy. I did experience hot flashes, mood swings, and slight insomnia. My fifth and sixth months were a little more difficult for me. The hot flashes became a little more apparent, the mood swings more frequent, and my face began to break out. To me, that was the worst. Along with the Lupron, I had a laparoscopy 2 months before the medication, and I started acupuncture treatments about a month before beginning Lupron, which really helped with the side effects. My pain levels before medication were unbearable. I could hardly bring myself to get out of bed. I now notice that my pain level is low if I have any at all."

• mom...
• Taken for 1 to 6 months
• June 18, 2015

"I took the shot for 6 months. I had issues that I could tolerate, such as vision change. The injection would shoot pain across my lower back. Well, it's been 8 months since I had a shot. It took me 2 months before my period returned. I recently started experiencing pain in my belly button. Vision was getting worse, mood swings. The end of April, my period was bad, then 2 weeks later, I had another one. I was ready to have everything removed. I had given up hope of having a baby... So, out of the blue, I missed my period, and now I'm 5 weeks PREGNANT!! I wish everyone good luck and hang in there!"

• Sin...
• September 4, 2019

"So I’ve been on Lupron Depot with an add-back for 10 months. I have severe endometriosis. I would bleed severely every month for at least two weeks, if not longer, with the worst pain of my life. I wanted to die. I definitely wasn’t living. The smallest movements, and I’d be soaked in blood. The pain was literally unbearable, and I’d have to make a trip to the emergency room. Yes, I do have side effects from the Lupron Depot: headaches, tired and drained, and for a few weeks out of my three-month cycle, my body hurts so bad I can barely walk around. But these side effects have nothing on the pain and depression I was suffering before. I had no life at all. Everything revolved around my period. It’s the only thing that’s given me relief."

• Ano...
• Taken for less than 1 month
• December 11, 2018

"I received my first shot almost 2 weeks ago. I am on the 3-month dosage. Absolutely no side effects the first couple of days, but pelvic/abdominal pain began day 3. My period came as normal on day 12 of getting the shot. I was really hoping to not have any at all. I will gladly deal with the more common side effects if my pain and period will go away! Only a few bouts of nausea and moments where I’ll feel so sad. I’m 39, no kids, and have been suffering from debilitating, life-altering pain since 12! I’m praying this helps!"

• Men...
• November 20, 2015

"This drug ruined my joints, chronic pain, I lost an inch in height, and my endometriosis was only gone for three years. I have gained 40 pounds, now have lost my mobility, can no longer dance or go out, I'm only 36, but I feel twice as old. I would never have taken it if I had known it was a chemotherapy drug for prostate cancer."

• Anonymous
• Taken for 6 months to 1 year
• February 7, 2016

"I had a laparoscopy done in March 2015, and they determined stage 4 endometriosis. Before then, I had maybe 1 week out of a month without pain for over a year, it was horrible. My first injection was in September 2015. I had a laparotomy in October 2015, the doctor did an amazing job and removed all the scar tissue and cysts. My second injection was in December 2015, and the hot flashes are brutal. I am now on a low dose of estrogen to help with the hot flashes. It has helped but not fully. I highly recommend the injection if you want to be pain-free, the hot flashes are brutal but way better than the pain."

• Ang...
• February 4, 2020

"My doctor told me about Lupron Depot, told me the side effects, and I was weary because it's an antineoplastic. I started it along with the add-back therapy of Provera 5 mg and had barely any side effects the first few weeks. Then I slowly started to gain hot flashes and some cramping in my right ovary where my cyst was. My period stopped before the second shot. I will say not to get it in the arm (deltoid) because my first shot was in my right arm, and it hurt even a month after. I get my fourth shot on the 18th, and I can tell you, the benefits will outweigh the negative side effects I'm having. So far I've had: thinning and loss of hair, my back and neck constantly hurt, hot flashes 2-6 times a day (mainly at night), vaginal dryness, which causes a lot of pain during sex, mood changes (I cry a lot)."

• Des...
• February 20, 2016

"Desperate for relief after 2 surgeries within 3 months of each other, I was so hopeful about this medication. I ignored the reviews and got the shot (11.75 dosage administered every 3 months). I regret my choice so much. First, the expense! Even with insurance, my out-of-pocket was $1,100. The mood swings were so bad that I became suicidal. I've gained 20 pounds that exercise and nutrition can't shed. The hot flashes were controlled by an OTC called Estroven. The pain did subside, but only for the 1st month after each shot (I got 2 shots total). Now, the pain is back and worse than ever and I'm only on month 5 of the treatment. Surgery #3 scheduled in 2 weeks. This med is NOT worth the side effects."

• Ali...
• October 24, 2013

"I just got my first shot 10 days ago. Was bleeding 2 weeks before the shot, and it has not stopped yet. Pain has gotten a little more intense and has interfered with my sleep. Skin is also more dry than usual. My fingers are crossed that this will work. I have had very painful cycles since I was a kid, and I'm ready to not have to call in sick to work and miss social activities due to pain. No hot flashes, mood swings, or any other side effects, maybe due to the progestin I'm on. Will probably post in another couple of weeks."

• KCM...
• Taken for 1 to 6 months
• May 28, 2016

"My first 3 weeks on Lupron were miserable. Painful, the heaviest period I've ever had, and just overall regretting my decision. It's now been about 2 months, and I'm feeling amazing! Hot flashes and forgetfulness, yes. But the pain is almost completely gone. My pain had me bedridden some days, and now my worst days just require a heating pad. I can't believe the turnaround."

• bit...
• June 11, 2016

"I was diagnosed with endometriosis during an appendectomy, but due to cluster headaches, hormones were contraindicated. Eventually, Lupron was advised. My mom, who NEVER had any menstrual cramps, told me horror stories, and I reacted as usual and agreed to the Lupron injections, and I have lived to regret it. Like so many others, I had severe menopausal symptoms, mood swings that made my fiancé think I was bipolar, and attempted suicide twice in a 3-month period, which is very unlike me. It caused weight gain, which I'd never had, and threw me into early menopause at the age of 46, 8 years after treatment. Now I'm suffering from acute hypertension, and I'm at risk for a stroke, which can't be attributed to anything else. But hey, no cramps!"

• Las...
• Taken for 6 months to 1 year
• February 4, 2021

"I've been suffering from endometriosis and ovarian cysts for 22 years. After trying all the hormones, we discovered I also had fibroids and adenomyosis. My doctor performed a hysterectomy with RSO. Even with that, I kept having cyclical bleeding and endo pain. We agreed on starting Lupron Depot for 6 months with progesterone add-back. I was incredibly nervous because of all the reviews. The first 2-3 weeks were pretty rough. Migraines, emotions all over the place. By week 4, I felt amazing! As the first 3-month shot started to wear off, symptoms began returning, and I couldn't wait for the next round. Dose #2 is coming to an end, and I can confidently say I haven't ever felt better. This drug was a dream come true for me! We've decided to proceed with removing the last ovary, and hopefully, I can start truly living life."

• ska...
• Taken for 1 to 6 months
• November 8, 2016

"I got a month shot right when I was about to start my period. Period ended up lasting about 12 days. I was told night sweats and menopausal symptoms would happen, but I did NOT expect the suicidal urges (I've been diagnosed with depression, but it was manageable before this shot), migraines - the worst migraines I've ever experienced in my life, nausea, cankles. I've had to take roughly 5 days off work just in the last 3 weeks, and I may even lose my job. I am so irritable and cannot sleep for the life of me. I wake up at least 30 times a night. I'd rather have my excruciating menstrual cramps than go through this ever again. My body did NOT like this AT ALL!"

• Hys...
• Taken for 1 to 6 months
• December 16, 2016

"At age 42, I had a partial hysterectomy (uterus only) to remove large fibroids. (Daughter was born when I was 32.) The doctor found stage IV endometriosis. He left my ovaries and said he never wanted to do surgery again - endo everywhere. He suggested Lupron to arrest the endo. It took me a year to start Lupron. I had to contact a foundation to qualify to receive the medication for free. I did two 3-month shots. I remember some hot flashes, nausea, and a few mood swings, but it passed fairly quickly. Now, I am 46 and in full menopause. I have osteopenia with some degenerative disc issues. Chronic back pain hurts most when laying on my stomach in bed. But I do not use pain meds or H.R.T. I hope the brain fog and other symptoms continue to improve."

• Kam...
• Taken for 1 to 6 months
• October 11, 2016

"I started this about 6-7 weeks ago after laparoscopy for small endo on my bowel, and the top of the cervix was unsuccessful. The first month was a nightmare. Started with worsening pain symptoms and an extra-long last period. Mood swings were outrageous. Crying all the time and a little feet/ankle swelling. Started adding back therapy and spironolactone a week ago, and as I reach the end of month two, I'm pain-free and I feel emotionally more stable. The side effects are manageable, at least right now. So if you can get past the initial period, it works."

• Mim...
• February 28, 2021

"Straight after the injection, I regret it because of the side effect, but after 3-5 days, it makes me feel better and brings my life back. It has been 8 years that I have been in pain, 1 ectopic pregnancy and terrible pain every single period. Too much medicine I had to take, and it is a risk to my kidney function, and no medication helped me at all. I just keep asking how come I only had this Lupron after 8 long years of suffering through the terrible pain. It makes me feel better and be able to do the things that I never ever did for 8 years because of 2-3 weeks in pain every period. Now I can do all the normal activities, and it feels so good to be up in the morning after having a good sleep and being pain free. I am looking forward to my second injection."