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Lupron Depot: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on April 3, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Lupron Depot is a hormone deprivation treatment that may be used for the palliative care of advanced prostate cancer. The main side effects are hot flashes and general pain and it may cause impotence, loss of libido, and atrophy of the testes. It is effective at slowing tumor progression in the majority of men.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Lupron Depot may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Lupron Depot. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

There are over 250 medications that have major or moderate interactions with Lupron Depot. Some common medications that may interact with Lupron Depot include:

Lupron Depot suppresses the pituitary-gonadal system which will affect diagnostic tests of pituitary gonadotropic and gonadal functions conducted during treatment and for three months after discontinuation.

Note that this list is not all-inclusive and includes only some common medications that may interact with Lupron Depot. You should refer to the prescribing information for Lupron Depot for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lupron Depot only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: April 2, 2023.