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Gonadotropin releasing hormone (GnRH) is a hormone produced in the hypothalamus and transported to the pituitary gland through the blood stream. GnRH controls the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. Secretion of GnRH is controlled by neural input from other parts of the brain and in females particularly, through negative feedback by the sex steroids.
More potent analogues of GnRH (compared to endogenous GnRH) have been synthesized and are used to treat endometriosis, fibroids, infertility and prostate cancer.
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