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Supprelin LA

Generic Name: histrelin (implant) (his TREL in)
Brand Names: Supprelin LA, Vantas

What is Supprelin LA?

Supprelin LA (histrelin) is a man-made form of a hormone that regulates many processes in the body. Histrelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.

Supprelin LA is subcutaneous implant and is used to treat precocious puberty in both male and female children. The implant is a small, thin flexible tube containing the medicine histrelin and is placed under the skin.

Supprelin LA may also be used for purposes not listed in this medication guide.

Important information

You should not receive Supprelin LA if you are allergic to histrelin or other medications that affect gonadotropin hormones. Supprelin LA is used to treat precocious puberty in children. Supprelin LA can cause a miscarriage or birth defects. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before you receive Supprelin LA, tell your doctor if you have painful or difficult urination, diabetes, heart disease, coronary artery disease, liver disease, a history of heart attack or stroke, osteoporosis, or a condition affecting your spine.

You may have a temporary increase in symptoms of your condition for a week or so after you have received the Supprelin LA implant. Call your doctor if any of these symptoms become severe.

Call your doctor at once if you have a serious side effect such as severe numbness or tingling in your legs or feet, muscle weakness, problems with balance or coordination, loss of bladder or bowel control, urinating more or less than usual, sudden numbness or severe headache, problems with speech or vision, increased thirst or urination, excessive hunger, or chest pain spreading to the arm or shoulder.

A Supprelin LA implant is usually left in place for 12 months and then removed. Your doctor will determine at that time whether you need to receive another implant for treatment of your symptoms.

Before receiving this medicine

You should not receive Supprelin LA if you are allergic to histrelin or to similar hormone medications such as leuprolide (Lupron, Eligard, Viadur), nafarelin (Synarel), or ganirelix (Antagon).

To make sure Supprelin LA is safe for you, tell your doctor if you have:

  • painful or difficult urination;

  • diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);

  • coronary artery disease (hardened arteries);

  • personal or family history of long QT syndrome;

  • liver disease;

  • a history of heart attack or stroke;

  • osteoporosis; or

  • a condition affecting your spine.

This medicine can harm an unborn baby or cause birth defects. Do not use Supprelin LA if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine.

It is not known whether histrelin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Supprelin LA given?

Supprelin LA is given in a tiny implant that is inserted under the skin on the inside of your upper arm. You will receive this implant with a minor surgical procedure in a clinic or doctor's office.

It is best to place the implant into your non-dominant arm (your left arm if you are right-handed). Be sure to tell your doctor which arm you use most often.

You should be lying on your back during insertion of the Supprelin LA implant. Your arm will be positioned with your elbow bent and held still while the implant is inserted. The skin of your upper arm will be treated with a numbing medicine to keep you from feeling pain during the insertion. Once your arm is numb, your doctor will use a scalpel to cut a small incision where the implant will be inserted.

The Supprelin LA implant is inserted using a special tool that pushes the implant into place through the incision in your skin. After injecting the implant and removing the insertion tool, your doctor will then feel your arm to make sure the implant has been correctly placed.

The incision in your skin may be closed with a small number of stitches or surgical strips. Follow your doctor's instructions about caring for the incision and keeping it bandaged and clean until it heals completely. Keep your arm dry for at least 24 hours.

You will most likely be able to feel the implant through your skin, but it should not cause pain or discomfort.

A Supprelin LA implant is usually left in place for 12 months and then removed.

Call your doctor if you have any pain, swelling, tenderness, itching, tingling, bruising, or redness where the implant was inserted. Also call your doctor if any part of the implant comes through the skin, or if the entire implant falls out.

You may have a temporary increase in symptoms of your condition for a week or so after you have received the Supprelin LA implant. Call your doctor if any of these symptoms become severe.

You will need regular medical tests to be sure this medicine is not causing harmful effects.

Supprelin LA can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using histrelin.

Whether or not you receive a new Supprelin LA implant, the old one must be removed after 12 months of use. A Supprelin LA implant must be removed through a surgical incision in your doctor's office.

Supprelin LA dosing information

Usual Pediatric Dose for Precocious Puberty:

Supprelin LA(R): One 50 mg implant inserted subcutaneously in the inner aspect of the upper arm
Duration of therapy: The implant should be removed after 12 months.

-To continue therapy, another implant may be inserted at the time an implant is removed.
-Discontinuation of therapy should be considered at the discretion of the physician and at the appropriate time point for the onset of puberty (approximately 11 years for females and 12 years for males).

Supprelin LA(R): Treatment of children with central precocious puberty

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Since Supprelin LA is given as an implant by a healthcare professional, it does not have a daily dosing schedule.

The implant should not be left in your arm for longer than 12 months. Call your doctor when it is time for your implant to be removed.

What happens if I overdose?

Since the Supprelin LA implant contains a specific amount of the medicine, you are not likely to receive an overdose.

What should I avoid after receiving a Supprelin LA?

For at least 7 days after your implant is inserted, avoid strenuous exercise or heavy lifting.

Histrelin can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Supprelin LA side effects

Get emergency medical help if you have signs of an allergic reaction to Supprelin LA: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe bone pain, severe numbness or tingling in your legs or feet;

  • painful or difficult urination;

  • blood in your urine; or

  • little or no urinating.

Common Supprelin LA side effects may include:

  • hot flashes;

  • urination problems;

  • constipation;

  • breast swelling or tenderness;

  • feeling tired;

  • decreased testicle size, trouble getting an erection; or

  • redness, bruising, or skin irritation where the implant was inserted.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Supprelin LA?

Other drugs may interact with histrelin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Supprelin LA.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Supprelin LA only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 6.02. Revision Date: 2017-03-20, 3:43:42 PM.