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Vantas

Generic Name: histrelin (implant) (his TREL in)
Brand Names: Supprelin LA, Vantas

What is Vantas?

Vantas (histrelin) is a man-made form of a hormone that regulates many processes in the body. Histrelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.

The Vantas implant is used to treat symptoms of prostate cancer in men.

Vantas treats only the symptoms of prostate cancer but does not treat the cancer itself.

Important information

Vantas can cause side effects such as crying spells, anger, aggression, and feeling restless or irritable. Call your doctor if you have any new or worsening mental problems.

Before you receive a Vantas implant, tell your doctor if you have painful or difficult urination, diabetes, heart disease, coronary artery disease, liver disease, a history of heart attack or stroke, osteoporosis, or a condition affecting your spine.

Call your doctor at once if you have a serious side effect such as severe numbness or tingling in your legs or feet, muscle weakness, problems with balance or coordination, loss of bladder or bowel control, urinating more or less than usual, sudden numbness or severe headache, problems with speech or vision, increased thirst or urination, excessive hunger, or chest pain spreading to the arm or shoulder.

A Vantas implant is usually left in place for 12 months and then removed. Your doctor will determine at that time whether you need to receive another implant for treatment of your symptoms.

Before I receive this medicine

You should not receive a Vantas implant if you are allergic to histrelin or to similar hormone medications such as leuprolide (Lupron, Eligard, Viadur), nafarelin (Synarel), or ganirelix (Antagon).

Vantas should not be used in women or children.

Do not use Vantas if you are pregnant. It could harm the unborn baby or cause a miscarriage. Use effective birth control to prevent pregnancy and tell your doctor right away if you become pregnant. This medicine is not for use in women.

To make sure Vantas is safe for you, tell your doctor if you have ever had:

  • painful or difficult urination;

  • diabetes;

  • heart problems, heart attack, or stroke;

  • a personal or family history of long QT syndrome;

  • an electrolyte imbalance (such as low levels of potassium in your blood);

  • low bone mineral density (osteoporosis); or

  • a condition affecting your spine.

It is not known whether histrelin passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Vantas is not approved for use by anyone younger than 18 years old.

How is Vantas given?

Vantas is given in a tiny implant inserted under the skin on the inside of your upper arm. You will receive this implant with a minor surgical procedure in a clinic or doctor's office.

It is best to place the implant into your non-dominant arm (your left arm if you are right-handed). Be sure to tell your doctor which arm you use most often.

While lying on your back, your arm will be positioned with your elbow bent and held still while the implant is inserted. The skin of your upper arm will be treated with a numbing medicine to keep you from feeling pain during the insertion. Once your arm is numb, your doctor will use a scalpel to cut a small incision where the implant will be inserted.

The Vantas implant is inserted using a special tool that pushes the implant into place through the incision in your skin. After injecting the implant and removing the insertion tool, your doctor will then feel your arm to make sure the implant has been correctly placed.

The incision in your skin may be closed with stitches or surgical strips. Follow your doctor's instructions about caring for the incision and keeping it bandaged and clean until it heals completely. Keep your arm dry for at least 24 hours.

You will most likely be able to feel the implant through your skin, but it should not cause pain or discomfort.

A Vantas implant is usually left in place for 12 months and then must be removed through a surgical incision. Do not try to remove the implant yourself. Your doctor will determine whether you need another implant for continued treatment.

Call your doctor if you have any pain, swelling, tenderness, itching, tingling, bruising, or redness where the implant was inserted, or if the implant comes through the skin or falls out.

To be sure this medicine is helping your condition, you may need frequent blood tests. Your blood work will help your doctor determine how long to treat you with Vantas.

Histrelin can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Vantas dosing information

Usual Adult Dose for Prostate Cancer:

One 50 mg implant inserted subcutaneously in the inner aspect of the upper arm
Duration of therapy: The implant should be removed after 12 months.

Comments: To continue therapy, another implant may be inserted at the time an implant is removed.

Use:
Palliative treatment of advanced prostate cancer

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Since Vantas is given as an implant by a healthcare professional, it does not have a daily dosing schedule.

The implant should not be left in your arm for longer than 12 months. Call your doctor when it is time for your implant to be removed.

What happens if I overdose?

Since the Vantas implant contains a specific amount of the medicine, you are not likely to receive an overdose.

What should I avoid after receiving a Vantas implant?

For at least 7 days after your implant is inserted, avoid strenuous exercise or heavy lifting.

Vantas side effects

Get emergency medical help if you have signs of an allergic reaction to Vantas: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bone pain, numbness or weakness in your legs or feet;

  • painful or difficult urination, blood in your urine;

  • a seizure; or

  • mental problems - crying spells, anger, aggression, feeling restless or irritable.

Common Vantas side effects may include:

  • hot flashes;

  • urination problems;

  • constipation;

  • breast swelling or tenderness (in males or females);

  • feeling tired;

  • decreased testicle size, trouble getting an erection; or

  • redness, bruising, or skin irritation where the implant was inserted.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Vantas?

Other drugs may interact with histrelin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Vantas.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vantas only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 7.01.

Date modified: July 02, 2017
Last reviewed: May 23, 2017

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