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Medications for Precocious Puberty

Precocious puberty is premature development of body characteristics that normally occur during puberty (the period in life at which rapid physical and physiologic changes occur, including development of reproductive capability). Puberty normally occurs between 13 and 15 years old in boys and between 9 and 16 years old in girls.

Females: onset of sexual development before 8 years of age including any of the following:

  • breast development
  • appearance of axillary or pubic hair
  • maturation of the external genitalia
  • onset of menses

There is some evidence that onset of development as early as 7 years of age in Caucasian girls and 6 years of age in African American girls may be considered normal.

Males: onset of sexual development before 9 years of age including any of the following:

  • enlargement of the testes and penis
  • appearance of axillary or pubic hair
  • appearance of facial hair usually first noted on the upper lip

Drugs used to treat Precocious Puberty

The following list of medications are in some way related to or used in the treatment of this condition.

Filter
Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Supprelin LA 5.5 2 reviews for Supprelin LA to treat Precocious Puberty
Rx X N
Generic name:
histrelin systemic
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Lupron Depot-PED 5.6 25 reviews for Lupron Depot-PED to treat Precocious Puberty
Rx X N
Generic name:
leuprolide systemic
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
tamoxifen Rate Add review
Rx D N
Generic name:
tamoxifen systemic
Brand name:
Soltamox
Drug class:
hormones/antineoplastics, selective estrogen receptor modulators
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
leuprolide 5.6 27 reviews for leuprolide to treat Precocious Puberty
Rx X N
Generic name:
leuprolide systemic
Brand names:
Lupron Depot-PED, Fensolvi
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Soltamox Rate Add review
Rx D N
Generic name:
tamoxifen systemic
Drug class:
hormones/antineoplastics, selective estrogen receptor modulators
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
triptorelin Rate Add review
Rx X N
Generic name:
triptorelin systemic
Brand name:
Triptodur
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
histrelin 5.5 2 reviews for histrelin to treat Precocious Puberty
Rx X N
Generic name:
histrelin systemic
Brand names:
Supprelin LA, Vantas
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Triptodur Rate Add review
Rx X N
Generic name:
triptorelin systemic
Drug class:
gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Vantas Rate Add review
Rx X N
Generic name:
histrelin systemic
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Synarel Rate Add review
Rx X N
Generic name:
nafarelin systemic
Drug class:
gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Fensolvi Rate Add review
Rx X N
Generic name:
leuprolide systemic
Drug class:
hormones/antineoplastics, gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
nafarelin 7.0 1 review for nafarelin to treat Precocious Puberty
Rx X N
Generic name:
nafarelin systemic
Brand name:
Synarel
Drug class:
gonadotropin releasing hormones
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph

Frequently asked questions

Learn more about Precocious Puberty

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.