Triptorelin Dosage

Medically reviewed by Drugs.com. Last updated on Jan 5, 2023.

Usual Adult Dose for Prostate Cancer

3.75 mg IM every 4 weeks
OR
11.25 mg IM every 12 weeks
OR
22.5 mg IM every 24 weeks

Comments:

• Administered as a single IM injection in either buttock; the injection site should be alternated periodically.
• Due to different release characteristics, the dosage strengths are not additive and must be selected based upon the desired dosing schedule.

Use: For the palliative treatment of advanced prostate cancer

Usual Pediatric Dose for Precocious Puberty

2 years and older:
22.5 mg IM every 24 weeks

Duration of therapy: Therapy should be discontinued at the onset of puberty at the discretion of the physician.

Comments:

• This drug should only be administered by a healthcare provider.
• Monitor response to this drug with LH levels after a GnRH or GnRH agonist stimulation test, basal LH, or serum concentration of sex steroid levels beginning 1 to 2 months following initiation of therapy, during therapy as necessary to confirm maintenance of efficacy, and with each subsequent dose.
• Measure height (for calculation of growth rate) every 3 to 6 months and monitor bone age periodically.
• Noncompliance with drug regimen or inadequate dosing may result in inadequate control of the pubertal process with gonadotropins and/or sex steroids increasing above prepubertal levels.
• If the dose of this drug is not adequate switching to an alternative GnRH agonist for the treatment of CPP with the ability for dose adjustment may be necessary.

Use: For the treatment of pediatric patients 2 years of age and older with central precocious puberty (CPP)

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS (NOTE: Check individual product package inserts for brand name specific information):

• Hypersensitivity to the active component or any of the ingredients or other GnRH agonists or GnRH
• Pregnancy

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• NOTE: Different products have different indications and dosing. Consult the manufacturer package insert before using product.
• Must be administered under the supervision of a physician.
• Alternate injection site periodically.

Storage requirements:

• Store at room temperature, do not freeze

Reconstitution/preparation techniques:

• Reconstitute in sterile water only; do not use any other diluent.
• Administer immediately after reconstitution.
• The manufacturer product information should be consulted.

Patient advice:

• Patients are likely to have an increase in testosterone after the first dose, which may worsen their symptoms during the first weeks of treatment.
• The increased testosterone and symptoms should decline after 3 to 4 weeks.
• Advise patients that there is an increased risk of developing diabetes, myocardial infarction, sudden cardiac death, and stroke.
• Advise patients that allergic reactions may occur, and serious reactions require immediate treatment.

Frequently asked questions

• How long can I take Trelstar (triptorelin) for prostate cancer?
• Why is triptorelin used for prostate cancer?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer