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Generic Name: olaparib (oh LAP a rib)
Brand Names: Lynparza

Medically reviewed by P. Thornton, DipPharm Last updated on Jun 27, 2019.

What is Lynparza?

Lynparza (olaparib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Lynparza is used to treat advanced ovarian cancer in women with a certain abnormal inherited gene who have responded to platinum chemotherapy.

Lynparza is also used to help maintain your body's response to prior chemotherapy for ovarian cancer, fallopian tube cancer, or peritoneal cancer when the cancer has come back.

Lynparza is also used to treat HER2-negative breast cancer that has spread to other parts of the body before or after prior chemotherapy or hormonal treatment.

Important Information

Lynparza affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, weakness, tiredness, trouble breathing, easy bruising or bleeding, blood in your urine or stools, or weight loss.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Lynparza may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.

Before taking this medicine

You should not use Lynparza if you are allergic to olaparib.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • lung disease, breathing problems; or

  • kidney disease.

Olaparib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

  • If you are a woman, do not use olaparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Also do not to donate sperm during the 3 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Lynparza.

Do not breast-feed while using this medicine, and for at least 1 month after your last dose.

How should I take Lynparza?

Take Lynparza exactly as it was prescribed for you. Your doctor will perform a blood test to make sure olaparib is the right treatment for your condition.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take Lynparza with or without food.

Do not crush, chew, dissolve, or break an Lynparza tablet. Swallow the tablet whole.

If your doctor changes your brand, strength, or type of olaparib, your dosage needs may change. Ask your pharmacist if you have any questions about the type of medicine you receive at the pharmacy.

Olaparib can lower blood cells that help your body fight infections and help your blood to clot. You will need weekly or monthly blood tests. You may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat.

Lynparza dosing information

Usual Adult Dose for Ovarian Cancer:

Initial dose: 300mg (two 150mg tablets) orally twice a day
Duration of therapy: Continue treatment until disease progression or unacceptable toxicity

Comments: Patients should be selected based on the presence of deleterious or suspected deleterious germline BRCA-mutations, as detected by an approved test.

Use: Monotherapy in patients with deleterious or suspected deleterious germline BRCA mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lynparza?

Grapefruit and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products and orange marmalades.

Lynparza side effects

Get emergency medical help if you have signs of an allergic reaction to Lynparza: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, flu symptoms;

  • sudden weakness or tired feeling;

  • chest pain, wheezing, shortness of breath, new or worsening cough;

  • painful mouth sores, red or swollen gums;

  • skin sores, red spots on the skin;

  • pale skin, easy bruising or bleeding;

  • severe or ongoing nausea or vomiting;

  • blood in your urine or stools; or

  • weight loss.

Common Lynparza side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lynparza?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lynparza only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.