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Generic Name: olaparib (oh LAP a rib)
Brand Names: Lynparza

Medically reviewed on Mar 1, 2018

What is Lynparza?

Lynparza (olaparib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Lynparza tablets and capsules are used to treat advanced ovarian cancer in women with a certain abnormal inherited gene who have received at least 3 prior types of chemotherapy.

Lynparza tablets are also used to help maintain your body's response to prior chemotherapy for ovarian cancer, fallopian tube cancer, or peritoneal cancer when the cancer has come back.

Lynparza tablets are also used to treat HER2-negative breast cancer that has spread to other parts of the body before or after prior chemotherapy or hormonal treatment.

Important Information

Serious and sometimes fatal infections may occur during treatment with Lynparza. Call your doctor right away if you have signs of infection such as: fever, weakness, feeling tired or short of breath, mouth sores, skin sores, easy bruising or bleeding, blood in your urine or stools, or weight loss.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Lynparza may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.

Before taking this medicine

You should not use Lynparza if you are allergic to olaparib.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • liver or kidney disease;

  • lung disease, breathing problems; or

  • bone marrow problems or other types of cancer.

Olaparaib can harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy, whether you are a man or a woman. The use of this medicine by either parent may cause birth defects.

If you are a woman, keep using birth control for at least 6 months after your last dose of Lynparza. If you are a man, keep using birth control for at least 3 months after your last dose. Also do not to donate sperm during the 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine.

It is not safe to breast-feed a baby while you are taking Lynparza. Also do not breast-feed for at least 1 month after your last dose.

How should I take Lynparza?

Take Lynparza exactly as it was prescribed for you. Your doctor will perform a blood test to make sure olaparib is the right treatment for your condition.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take Lynparza with or without food.

Do not crush, chew, dissolve, or break a capsule or tablet. Swallow the pill whole.

If your doctor changes your brand, strength, or type of olaparib, your dosage needs may change. Ask your pharmacist if you have any questions about the Lynparza pills you receive at the pharmacy.

Lynparza capsules must not be used as a substitute for Lynparza tablets. These two pill forms are not taken in the same dosage amounts.

Olaparib can lower blood cells that help your body fight infections and help your blood to clot. You will need weekly or monthly blood tests. You may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat.

Do not use any capsules that have been exposed to high heat (higher than 104 degrees F).

Lynparza dosing information

Usual Adult Dose for Ovarian Cancer:

Initial dose: 400 mg (eight 50 mg capsules) orally twice a day
Duration of therapy: Continue treatment until disease progression or unacceptable toxicity

Comments: Patients should be selected based on the presence of deleterious or suspected deleterious germline BRCA-mutations, as detected by an approved test.

Use: Monotherapy in patients with deleterious or suspected deleterious germline BRCA mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lynparza?

Grapefruit, grapefruit juice, and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products while taking Lynparza.

Lynparza side effects

Get emergency medical help if you have signs of an allergic reaction to Lynparza: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with olaparaib. Call your doctor right away if you have signs of infection such as:

  • fever, chills, flu symptoms;

  • sudden weakness or tired feeling;

  • painful mouth sores, red or swollen gums;

  • skin sores, red spots on the skin;

  • pale skin, easy bruising or bleeding;

  • blood in your urine or stools; or

  • weight loss.

Call your doctor at once if you have:

  • wheezing, shortness of breath, new or worsening cough;

  • chest pain; or

  • severe or ongoing nausea or vomiting.

Common Lynparza side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Lynparza?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lynparza only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.