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Generic Name: olaparib (oh LAP a rib)
Brand Names: Lynparza

What is Lynparza?

Lynparza (olaparib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Lynparza is used to treat advanced ovarian cancer in women with a certain abnormal inherited gene. Lynparza is usually given after at least 3 other cancer medicines have been tried without success.

Lynparza was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, olaparib produced complete or partial response in many women. However, further studies are needed to determine if this medicine can lengthen survival time.

Important information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Lynparza if you are allergic to olaparib.

To make sure Lynparza is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • lung disease or breathing problems;

  • a history of bone marrow problems or other types of cancer; or

  • a history of treatment with other cancer medicines or radiation treatment.

Do not use Lynparza if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your treatment ends.

It is not known whether olaparib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Lynparza.

How should I take Lynparza?

Take Lynparza exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Your doctor will perform a blood test to make sure Lynparza is the right treatment for your condition.

Do not crush, chew, dissolve, or open a Lynparza capsule. Swallow it whole.

Do not use a pill that is broken or damaged. Call your pharmacist for new medicine.

Lynparza can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. You may also need chest x-rays to be sure this medicine is not causing harmful effects on your lungs. Your cancer treatments may be delayed based on the results of these tests.

Store Lynparza at room temperature away from moisture and heat. Do not use the medicine if it has been exposed to high heat (higher than 104 degrees).

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Lynparza dosing information

Usual Adult Dose for Ovarian Cancer:

Initial dose: 400 mg (eight 50 mg capsules) orally twice a day
Duration of therapy: Continue treatment until disease progression or unacceptable toxicity

Comments: Patients should be selected based on the presence of deleterious or suspected deleterious germline BRCA-mutations, as detected by an approved test.

Use: Monotherapy in patients with deleterious or suspected deleterious germline BRCA mutated advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Lynparza?

Grapefruit, grapefruit juice, and Seville oranges may interact with olaparib and lead to unwanted side effects. Avoid the use of grapefruit products while taking Lynparza.

Lynparza side effects

Get emergency medical help if you have signs of an allergic reaction to Lynparza: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with Lynparza. Call your doctor right away if you have signs of infection such as:

  • fever, chills, sore throat, cold or flu symptoms;

  • sudden weakness or tired feeling;

  • painful mouth sores, pain when swallowing, red or swollen gums;

  • pale skin, skin sores, red spots on the skin;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum);

  • rapid heart rate, cough, trouble breathing; or

  • weight loss.

Call your doctor at once if you have:

  • wheezing, shortness of breath, new or worsening cough;

  • blood in your urine or stools; or

  • severe or ongoing nausea or vomiting.

Common Lynparza side effects may include:

  • infections;

  • feeling weak or tired;

  • heartburn, indigestion, stomach pain, loss of appetite;

  • nausea, vomiting, diarrhea;

  • headache, back pain, muscle or joint pain;

  • altered sense of taste;

  • abnormal kidney function tests;

  • rash; or

  • cold symptoms such as stuffy or runny nose, sneezing, cough, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Lynparza?

Other drugs may interact with olaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Lynparza.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lynparza only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 1.02. Revision Date: 2016-11-15, 8:17:01 AM.