Skip to Content

Lynparza Side Effects

Generic Name: olaparib

Note: This page contains information about the side effects of olaparib. Some of the dosage forms included on this document may not apply to the brand name Lynparza.

In Summary

Common side effects of Lynparza include: upper respiratory tract infection, anemia, decreased hemoglobin, increased mcv, increased serum creatinine, nasopharyngitis, nausea, pharyngitis, vomiting, cough, and dyspnea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olaparib: oral capsule

In addition to its needed effects, some unwanted effects may be caused by olaparib (the active ingredient contained in Lynparza). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking olaparib:

More common:
  • Chest pain
  • chills
  • cough
  • ear congestion or pain
  • fever
  • head congestion
  • hoarseness or other voice changes
  • nasal congestion
  • pale skin
  • runny nose
  • sneezing
  • sore throat
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Lower back or side pain
  • painful or difficult urination
  • sores, ulcers, or white spots on lips or in the mouth
  • swollen glands

Minor Side Effects

Some of the side effects that can occur with olaparib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • back pain
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • difficulty with moving
  • dry mouth
  • fear or nervousness
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • heartburn
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • lack or loss of strength
  • loss of bladder control
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • stomach discomfort, upset, or pain
  • sweating
  • swelling or inflammation of the mouth
  • trouble sleeping
  • unexplained weight loss
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to olaparib: oral capsule

Oncologic

Uncommon (0.1% to 1%): Myelodysplastic syndrome/Acute Myeloid Leukemia[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (up to 90%), elevated mean corpuscular volume (up to 85%), decreased lymphocytes (up to 56%), anemia (up to 34%), decreased absolute neutrophil count (up to 32%), decreased platelets (up to 30%)
Common (1% to 10%): Leukopenia[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis/pharyngitis/upper respiratory infection (up to 43%), cough (up to 21%), dyspnea
Common (1% to 10%): Pulmonary embolism
Uncommon (0.1% to 1%): Pneumonitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 75%), abdominal pain/discomfort (up to 47%), vomiting (up to 43%), diarrhea (up to 31%), dyspepsia (up to 25%), constipation
Common (1% to 10%): Stomatitis[Ref]

Other

Very common (10% or more): Fatigue/asthenia/lethargy (up to 68%), peripheral edema
Common (1% to 10%): Pyrexia[Ref]

Renal

Very common (10% or more): Increased creatinine (up to 30%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia/musculoskeletal pain (up to 32%), myalgia (up to 25%), back pain (up to 25%)[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, hot flush, venous thrombosis[Ref]

Dermatologic

Very common (10% or more): Dermatitis/rash (up to 25%)
Common (1% to 10%): Dry skin, eczema, pruritus[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection
Common (1% to 10%): Dysuria, urinary incontinence, vulvovaginal disorder[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 25%)
Common (1% to 10%): Hypomagnesemia, hyperglycemia[Ref]

Nervous system

Very common (10% or more): Headache (up to 25%), dysgeusia (up to 21%), dizziness
Common (1% to 10%): Peripheral neuropathy[Ref]

Psychiatric

Common (1% to 10%): Anxiety, depression, insomnia[Ref]

References

1. "Product Information. Lynparza (olaparib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Not all side effects for Lynparza may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide