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Lynparza Side Effects

Generic Name: olaparib

Note: This document contains side effect information about olaparib. Some of the dosage forms listed on this page may not apply to the brand name Lynparza.

In Summary

Common side effects of Lynparza include: upper respiratory tract infection, anemia, decreased hemoglobin, increased mcv, increased serum creatinine, nasopharyngitis, nausea, pharyngitis, vomiting, cough, and dyspnea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to olaparib: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, olaparib (the active ingredient contained in Lynparza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olaparib:

More common

  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • bloody or cloudy urine
  • body aches or pain
  • chest pain
  • chills
  • cough
  • cough producing mucus
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty breathing
  • ear congestion or pain
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • head congestion
  • headache
  • hoarseness or other voice changes
  • joint pain
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • muscle aches and pains
  • nasal congestion
  • nausea
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swollen glands
  • tightness in the chest
  • trouble sleeping
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Fast heartbeat
  • hives, itching, skin rash
  • irritation
  • joint stiffness or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • troubled swallowing

Side effects not requiring immediate medical attention

Some side effects of olaparib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • constipation
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • difficulty with moving
  • dizziness
  • dry mouth
  • fear or nervousness
  • flushed, dry skin
  • fruit-like breath odor
  • heartburn
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • lack or loss of strength
  • loss of bladder control
  • loss of or change in taste
  • muscle stiffness
  • pain in the joints
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • unexplained weight loss
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to olaparib: oral capsule, oral tablet

Oncologic

Uncommon (0.1% to 1%): Myelodysplastic syndrome/Acute Myeloid Leukemia[Ref]

Hematologic

Very common (10% or more): Decreased hemoglobin (up to 90%), elevated mean corpuscular volume (up to 85%), decreased lymphocytes (up to 56%), anemia (up to 34%), decreased absolute neutrophil count (up to 32%), decreased platelets (up to 30%)

Common (1% to 10%): Leukopenia[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis/pharyngitis/upper respiratory infection (up to 43%), cough (up to 21%), dyspnea

Common (1% to 10%): Pulmonary embolism

Uncommon (0.1% to 1%): Pneumonitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 75%), abdominal pain/discomfort (up to 47%), vomiting (up to 43%), diarrhea (up to 31%), dyspepsia (up to 25%), constipation

Common (1% to 10%): Stomatitis[Ref]

Other

Very common (10% or more): Fatigue/asthenia/lethargy (up to 68%), peripheral edema

Common (1% to 10%): Pyrexia[Ref]

Renal

Very common (10% or more): Increased creatinine (up to 30%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia/musculoskeletal pain (up to 32%), myalgia (up to 25%), back pain (up to 25%)[Ref]

Cardiovascular

Common (1% to 10%): Hypertension, hot flush, venous thrombosis[Ref]

Dermatologic

Very common (10% or more): Dermatitis/rash (up to 25%)

Common (1% to 10%): Dry skin, eczema, pruritus[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection

Common (1% to 10%): Dysuria, urinary incontinence, vulvovaginal disorder[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 25%)

Common (1% to 10%): Hypomagnesemia, hyperglycemia[Ref]

Nervous system

Very common (10% or more): Headache (up to 25%), dysgeusia (up to 21%), dizziness

Common (1% to 10%): Peripheral neuropathy[Ref]

Psychiatric

Common (1% to 10%): Anxiety, depression, insomnia[Ref]

References

1. "Product Information. Lynparza (olaparib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.