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Gemcitabine

Generic name: gemcitabine [ jem-SYE-ta-been ]
Brand names: Infugem, Gemzar
Dosage forms: intravenous powder for injection (1 g; 2 g; 200 mg), intravenous solution (10 mg/mL-NaCl 0.9%; 100 mg/mL; 38 mg/mL)
Drug class: Antimetabolites

Medically reviewed by Drugs.com on Aug 14, 2023. Written by Cerner Multum.

What is gemcitabine?

Gemcitabine is used to treat cancers of the pancreas, lung, ovary, and breast.

Gemcitabine is sometimes given with other cancer medicines, or when other cancer treatments did not work or have stopped working.

Gemcitabine may also be used for purposes not listed in this medication guide.

Gemcitabine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Also call your doctor at once if you have:

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of gemcitabine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Gemcitabine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, tiredness, bruising or bleeding, pale skin).

Gemcitabine can also affect your liver, kidneys, or lungs. Tell your doctor if you have stomach pain, dark urine, yellow skin or eyes, little or no urinating, swelling, rapid weight gain, severe shortness of breath, wheezing, or cough with foamy mucus.

If you receive gemcitabine during or after radiation treatment, tell your doctor right away if you have severe skin redness, swelling, oozing, or peeling.

Before taking this medicine

You should not use gemcitabine if you are allergic to it.

Tell your doctor if you have ever had:

Both men and women using gemcitabine should use effective birth control to prevent pregnancy. Gemcitabine can harm an unborn baby if the mother or father is using this medicine.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because gemcitabine can harm an unborn baby.

You should not breastfeed while you are using gemcitabine, and for at least 1 week after your last dose.

How is gemcitabine used?

Gemcitabine is given as an infusion into a vein. A healthcare provider will give you this injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when gemcitabine is injected.

If any of this medicine accidentally gets on your skin, wash the area thoroughly with soap and warm water.

Gemcitabine can increase your risk of bleeding or infection. You will need frequent medical tests.

Enhertu, Kisqali, Verzenio, Opdivo, methotrexate, Keytruda, Arimidex, pembrolizumab, fluorouracil, capecitabine

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your gemcitabine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using gemcitabine?

Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding or injury.

Do not receive a "live" vaccine while using gemcitabine, and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What other drugs will affect gemcitabine?

Other drugs may affect gemcitabine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does gemcitabine interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.