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Triptorelin: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on April 3, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist, that mimics the action of GnRH. After an initial transient surge, it causes a sustained decrease in FSH and LH and a significant reduction in ovarian and testicular steroidogenesis usually 2 to 4 weeks after initiation. It may be used to treat advanced prostate cancer, central precocious puberty, or to prevent a premature LH surge in women undergoing ovarian hyperstimulation for ART. Hot flashes are the main side effect in men with prostate cancer.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with triptorelin may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with triptorelin. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

There are over 255 medications that have major or moderate interactions with triptorelin. Some common medications that may interact with triptorelin include:

Triptorelin can increase the risk of QT prolongation, a potentially life-threatening irregular heart rhythm. Those at higher risk include people with congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (such as magnesium or potassium loss due to severe or prolonged diarrhea or vomiting).

Triptorelin suppresses the pituitary-gonadal system which will affect diagnostic tests of pituitary gonadotropic and gonadal functions conducted during treatment and for eight weeks after discontinuation.

Hyperprolactinemic drugs (such as bromocriptine, lisuride, or metoclopramide) should not be used at the same time as triptorelin since hyperprolactinemia reduces the number of pituitary GnRH receptors.

Note that this list is not all-inclusive and includes only some common medications that may interact with Triptorelin. You should refer to the prescribing information for Triptorelin for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use triptorelin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: April 2, 2023.