Histrelin Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 16, 2024.

Applies to histrelin: subcutaneous implant.

Precautions

It is very important that your doctor check the progress of you or your child at regular visits to make sure the implant is in the proper place and is working properly. Blood tests may be needed to check for unwanted effects.

For female patients: You should not receive this medicine if you are pregnant or may become pregnant. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine. If you think you have become pregnant while using the medicine, tell your doctor right away.

You may have some pain, redness, or bruising at the site where the implant is placed. If your arm has not healed within 2 weeks after you received the implant or if you continue to have redness or pain, call your doctor.

For children using Supprelin® LA:

• The medicine can cause a brief increase in blood levels of some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. If your child's symptoms do not improve within 4 weeks, or if they get worse, call your doctor.
• This medicine may cause some children to be agitated, irritable, or display other abnormal behaviors. Make sure the doctor knows if your child is having trouble sleeping, gets upset easily, has a big increase in energy, or starts to act reckless. Also tell the doctor if your child has sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.
• Using this medicine may increase your child's risk of having seizures. Check with your doctor right away if your child starts to have convulsions, muscle spasm or jerking of all extremities, sudden loss of consciousness, or loss of bladder control.
• This medicine may cause intracranial hypertension or pseudotumor cerebri (increased pressure in the head) in children. Check with your doctor right away if your child has blurred or double vision, change in ability to see colors, especially blue or yellow, continuing ringing or buzzing or other unexplained noise in the ears, dizziness, eye pain, hearing loss, nausea and vomiting, or severe headache.

For male patients:

• When you start using Vantas®, some of your symptoms might get worse for a short time. You might also have new symptoms such as bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating. The symptoms should improve in a few weeks. Tell your doctor if you have any new symptoms or your symptoms get worse.
• This medicine may cause your blood sugar level to increase. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.
• This medicine may increase your risk of having a heart attack or stroke. Check with your doctor right away if you have chest pain or discomfort, difficulty with speaking, headache, pain or discomfort in the arms, jaw, back or neck, sweating, trouble breathing, or vomiting while using the medicine.
• Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

Before you have any medical tests, tell the medical doctor in charge that you are using histrelin implant. The results of some tests may be affected by this medicine.

Common side effects of histrelin

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of histrelin

Along with its needed effects, histrelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:

For healthcare professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit.

Endocrine adverse events

• Common (1% to 10%): Elevated blood glucose, gynecomastia
• Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone
• Rare (less than 0.1%): Benign pituitary tumor
• Postmarketing reports: Pituitary apoplexy^[Ref]

Cardiovascular

• Very common (10% or more): Hot flashes (66%)
• Common (1% to 10%): Blushing
• Uncommon (0.1% to 1%): Hematoma, peripheral edema
• Rare (less than 0.1%): Palpitations, ventricular extrasystoles^[Ref]

Local

• Very common (10% or more): Implant/application site reaction (51%)
• Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain
• Postmarketing reports: Implant breakage^[Ref]

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.^[Ref]

Other

• Common (1% to 10%): Asthenia, fatigue
• Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise
• Rare (less than 0.1%): Wound infection, disease progression^[Ref]

Psychiatric

• Common (1% to 10%): Mood changes, depression, decreased libido, insomnia
• Uncommon (0.1% to 1%): Irritability^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, pain in the extremities
• Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia^[Ref]

Dermatologic

• Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis
• Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis
• Rare (less than 0.1%): Skin infection^[Ref]

Gastrointestinal

• Common (1% to 10%): Constipation
• Uncommon (0.1% to 1%): Abdominal discomfort, nausea^[Ref]

Genitourinary

• Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention
• Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency
• Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Anemia^[Ref]

Hepatic

• Common (1% to 10%): Hepatic disorder
• Uncommon (0.1% to 1%): Elevated aspartate aminotransferase
• Postmarketing reports: Drug-induced liver injury^[Ref]

Immunologic

• Rare (less than 0.1%): Influenza-like illness^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Tremor, lethargy
• Rare (less than 0.1%): Migraine
• Postmarketing reports: Seizures/convulsions^[Ref]

Renal

• Common (1% to 10%): Impaired renal function
• Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance^[Ref]

Respiratory

• Common (1% to 10%): Exertional dyspnea
• Rare (less than 0.1%): Epistaxis^[Ref]

See also:

Frequently asked questions

• Is Supprelin LA the same as Lupron?
• How quickly does Supprelin LA work?

Further information

Histrelin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer