Skip to Content

User Reviews for Leuprolide

Also known as: Eligard, Lupron Depot, Fensolvi Lupron Depot-PED Camcevi

Leuprolide has an average rating of 5.8 out of 10 from a total of 317 ratings on Drugs.com. 44% of those users who reviewed Leuprolide reported a positive effect, while 34% reported a negative effect.

Condition Avg. Rating Reviews Compare
Endometriosis  
5.5
151 reviews 102 medications
Prostate Cancer  
5.8
78 reviews 56 medications
Uterine Fibroids  
6.3
61 reviews 4 medications
Precocious Puberty  
6.1
25 reviews 17 medications
Breast Cancer, Adjuvant  Off-label
2.0
1 reviews 23 medications
Female Infertility  Off-label
9.0
1 reviews 24 medications
Summary of Leuprolide reviews 5.8 317 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Leuprolide

chiomaritaN May 15, 2021

Lupron Depot (leuprolide) for Uterine Fibroids: “I took luprodex 3.75mg injection for 5 months on monthly basis to reduce the severe cramp.and pain associated with monthly flow. First month of injection was still painful but the subsequent months were normal and I also ovulated well on month 4. Then after the last dose, it took just 6 weeks before my period returned. It was quite normal but with a very light right abdominal cramp. I will do scan to check if the bulky uterus has reduced because I want to conceive too. One important observation is that it did not stop my period for those months . I usually see my period each month but did not see the next month when I stopped the injection. It was a beautiful experience though I had severe leg cramp/ arthritis...”

8 / 10
Was this helpful?YesNo
surferman · Taken for 1 to 2 years March 27, 2021

Lupron Depot (leuprolide) for Prostate Cancer: “Had a prostatectomy in Oct. 2019 and PSA rose in April 2020. Took bicaltumide pills and a lupron injection in Aug 2020. second injection in Jan 2021. The next injection is May 2021. My side effects are mostly really bad hot flashes day and night, extra fat around waist, got the mood thing going. My wife said I should talk to doc before next dose. I also got an inguinal hernia after surgery . It is a hard drug to live with but at 71 years old I'll take every day. I see the doc next month for a checkup after a blood test. I also had 39 radiation visits in Jan 2021. I hope my PSS is still around 0.034 due to lupron. I have to take a total of 5 injections which have been every 4 months. Good luck to people who have to take this route.”

7 / 10
Was this helpful?YesNo
geezer46 · Taken for 1 to 2 years March 6, 2021

Lupron Depot (leuprolide) for Prostate Cancer: “I completely agree with Rob, if i had have known the consequences of taking this drug, I would probably done the same as him. It takes away everything that being a man is. He does not however mention the sex word, from my first injection 5 years ago there has not been any, plenty of everything else that he states but no kind of love making. Probably he did not take enough to cause e/d, if not good on him. Not enough information is given to us about the FULL effects of this drug, men are not made to live a good QOL without testosterone, because after you have been castrated that is it. As far as I can tell very few men have good sex and real happiness after having the drug.”

1 / 10
Was this helpful?YesNo

Frequently asked questions

Bill May 21, 2020

Eligard (leuprolide) for Prostate Cancer: “Massive radical prostrate surgery 1997. Clear of the return of cancer until 2016, low PSA of 18 when discovered at my annual physical. No radiation, only Eligard every six months. Here it is 2020 and I am 86 years of age. Only side effects are increase in weight (15 pounds), low energy level, and increased breast size. Never hot flashes or sweating. COVID-19 has keep my wife and I house bound for the past 3 months and we enjoy life in states of happiness, bliss and joy. If one lives long enough, prostrate cancer will eventually put you under. Too many symptoms to make a doctor's appointment. When I think it is cancer of the wrist, it's arthritis. When I think it's cancer of lumbar region, it's vertebrae disks. So why think you're going to live forever. Enjoy the love your wife, children and friends offer and learn to enjoy how cancer progresses during the last phase of life. My wife has NEVER heard me complain.”

10 / 10
Was this helpful?YesNo
Rob February 25, 2021

Eligard (leuprolide) for Prostate Cancer: “Got the results back, in September 2020 had a biopsy (thanks for the delay covid) came back with Gleeson score of 9 and Grade 5! They tried to operate but too much scar tissue. Next was the oncologist appointment who said we need to do something now and said eligard should stop it growing . What they didn't say was that I would put weight on, the night sweats make you put covers on, take covers of all night, Getting up to pee up to 9 times a night, Feeling lethargic, Dark thoughts and mood swings, An emotional wreck. Went to the gp who put me on anti depression tablets which have amplified my emotional state.... told the wife tonight I'm not taking any more anti depressants, not doing eligard and not going to a planning day. I want to go out on my terms feeling like myself not juiced up on this rubbish. Facts are I could have some good years left without medication or go on feeling wound up and unintentionally pushing away those that care.”

1 / 10
Was this helpful?YesNo
TZAK January 3, 2012

Lupron Depot (leuprolide) for Uterine Fibroids: “I just received my 2nd shot of 3.75 Lupron and so far so good! I have heard horror stories not only on line, but from my friends who have been on it for various reasons and I was more than worried to start it. I have one large fibroid and I was put on Lupron injections to shrink it to make it easier for my husband and I to have a baby after I have a robotic myomectomy in June. I was so afraid of mood swings, but surprisingly, after 5 weeks I am still very happy. My bloating has gone away for the most part and I am really looking forward to not bleeding the way I did due to this fibroid! All in all, I am posting on here so that woman like myself, a 35 year old wanting a baby will know that not all Lupron horror stories will happen to you!”

7 / 10
Was this helpful?YesNo
Steelie · Taken for 1 to 6 months October 26, 2020

Eligard (leuprolide) for Prostate Cancer: “I was given a six-month injection on Eligard 45mg, then 3 days later I had a CV event on me in the emergency room. Other side effect that Eligard has given me is I've had bone pain, severe neuropathy, night sweats, night terrors, brain fog, confusion, anxiety and anger.”

1 / 10
Was this helpful?YesNo

More FAQ

Steve · Taken for 1 to 6 months January 29, 2021

Eligard (leuprolide) for Prostate Cancer: “My side effects from Eligard is extreme bone pain, joint pain, testicular pain, my penis shriveled up like I had jumped in ice water and stayed icy cold for several days, night sweats, night terrors, nightmares, brain fog. I had a CV event 3 days after wound up in the emergency room with extreme difficulty and pain urinating, especially at night. According to the manufacturer this is supposed to be used for palliative care Well I guess they don't know the meaning of palliative care I wish I had never started this treatment”

1 / 10
Was this helpful?YesNo
Wally · Taken for less than 1 month January 9, 2020

Eligard (leuprolide) for Prostate Cancer: “Have had one month injection of Eligard and will not be taking another. Side effects including hot flashes, night sweats, fatigue, joint pains, mood swings, memory loss - I get the lot. Worst decision I ever made and hope the effects wear off ASAP. I would rather take my chances than be half the person I am now. Reading other comments where there seems to be no ending to the side effects gives me little hope for a reprieve. Oncologist gave me no impression I would be suffering like this. Just "this is the standard treatment" - it does not cure the disease just supposedly slows it. Personally I would rather have less time and good quality of life.”

3 / 10
Was this helpful?YesNo
pofoto · Taken for 2 to 5 years October 25, 2020

Eligard (leuprolide) for Prostate Cancer: “I was diagnosed with prostate cancer in 2014 at 64 years old. My doctor said my best option for getting rid of the cancer was to have it removed. I went through the surgery in August 2014, but the cancer was not gone. I had 38 radiation treatments in 2015, and that kept my PSA low for two years. It went up to 1.0, and the doctor started giving me Eligard injections every 3 months beginning in 2018. I have severe depression with dark thoughts concerning my death eventually from this cancer. I also have weight gain, and no sexual desires at all. I have no toleranceor patience and it makes me very irritable. I must admit it works as it has kept my PSA below 1.0 for the last two years! I don't think I will take it much longer. My doctor is saying they are looking for a different treatment soon. I have no idea what that will be. It has taken all the joy of life out of me and I am not interested in almost anything...”

5 / 10
Was this helpful?YesNo
Peartree · Taken for 1 to 6 months December 19, 2019

Eligard (leuprolide) for Prostate Cancer: “I am 68 years old. Had 6 mo. injection August 2018. Dr. told me hot flashes and night sweats were the side effects. That I could handle. What I could not handle was the loss of cognitive functions, mood swings, loss of muscle mass, weight gain, thoughts of suicide, total ED, shrunken penis and testicles. It has destroyed my life. I have still not recovered all of the cognitive functions I lost, can not get rid of the extra weight and to top it all off, my cancer was not to the point I needed the hormone. Eligard may have saved lives, but to me the treatment has destroyed my quality of life.”

1 / 10
Was this helpful?YesNo
Conmgr · Taken for 2 to 5 years October 2, 2013

Lupron (leuprolide) for Prostate Cancer: “Have been on Lupron for about 2 years and my stage 4 prostate cancer is now in remission. My prostate cancer specialist gets all the credit and kept side effects to a minimum with the help of other meds and supplements. I recommend Lupron.”

9 / 10
Was this helpful?YesNo
olscout September 17, 2014

Lupron (leuprolide) for Prostate Cancer: “Had my first Lupron shot before 45 days of radiation. Having hot flashes,muscle and joint pain but not too bad. Doing the shot every 3 months. Psa went from 11.5 to 0.1. Next shot coming up in couple weeks. Don't have a problem with the shot or after having it. I think Lupron has been helping me, but everyone has different experiencies with it. Good luck to all you prostate cancer people.”

10 / 10
Was this helpful?YesNo
Joya · Taken for 1 to 6 months February 7, 2019

Lupron Depot (leuprolide) for Uterine Fibroids: “I believe having this injection and educating yourself on the side effects goes hand in hand. I knew it could cause depletion of bones, I doubled up on calcium. I knew it would throw me into menopause, I immediately and consistently took black cohash. I had a hemoglobin of 6.5. It stopped my heavy periods which allowed it to rise to 12 in order to not have to have a transfusion during or after my hysterectomy. Educate yourself and prepare your body for the injection. The injection can not do all of the work, nor should you expect to.”

8 / 10
Was this helpful?YesNo
fibroids suck! · Taken for 1 to 6 months January 22, 2015

Lupron Depot (leuprolide) for Uterine Fibroids: “Awesome stuff! I went on Lupron so I could be a candidate for focused ultrasound treatment. Don't let all the negative reviews scare you! I used to look about 4 months pregnant. I am otherwise healthy, thin and exercise regularly. Had minor hot flashes; not a big deal considering the overall benefits. My mass of fibroids shrank dramatically in 3 months. Previously hard, round abdominal area shrank considerably! I couldn't believe how successful Lupron was for me, and how good I felt on it. I went off the pill (which I was on for years for constant bleeding/spotting). Didn't have memory loss, hair loss or bad moods like many other women's experiences. I took vitamins while on it to help counteract things like possible bone loss.”

10 / 10
Was this helpful?YesNo
Bart · Taken for 1 to 6 months May 2, 2020

Eligard (leuprolide) for Prostate Cancer: “Diagnosed with prostate cancer in April 2019, had a 6 month Lupron shot in May followed by 45 radiation treatments ending in early September. Went on vacation and able to do 2-3 mile hikes over rough terrain with only a little fatigue. Went in for second shot early November and they changed me to Eligard. They said it was virtually the same product. Within 2 weeks I developed intense pain in my hips that has not gone away. Can hardly walk to the mailbox any longer due to the pain. Dealing with mood swings, minor depression, trouble sleeping and have gained 30 pounds. Due to go back next Wednesday for another 6 month Eligard shot. Not going to happen.”

1 / 10
Was this helpful?YesNo
walking dead....... · Taken for 5 to 10 years March 5, 2014

Lupron (leuprolide) for Prostate Cancer: “I was 50, had my prostate removed then let it go at 55. Had a PSA above 400, my weight dropped to 105lbs thought I was going to die then had 15 radaiaton treatments and started Lupron shots. PSA dropped, I came back to life now I an 63 still getting Lupron shots every 6 months sure there are some side effects but its better than being dead if you have cancer. I hope something works for you.”

8 / 10
Was this helpful?YesNo
clauscn December 10, 2009

Lupron (leuprolide) for Prostate Cancer: “I have been receiving Lupron or Eligard every 6 months for ten years to help reduce the growth of prostate cancer. Early research reports indicated that one side effect might be peripheral neuropathy. That started to develop in my feet shortly after I was put on Lupron. Loss of bone mass has also been associated with Lupron. I have begun taking 1200 units of calcium VitaminD each day. My PSA scores have all continued to be below .1. I have no major complaints, and have learned to live with the side effects.”

8 / 10
Was this helpful?YesNo
Lupron Depot: not that bad · Taken for 1 to 6 months February 19, 2019

Lupron Depot (leuprolide) for Uterine Fibroids: “I wanted to write a review for other women who are thinking about getting this injection. I read a lot of horror stories online so I was pretty nervous. I got the 3 month injection to try and shrink my large fibroids. Upshot is, it wasn't that bad but my fibroids didn't shrink; however, it stopped my periods. Preventing the excessive bleeding is good for health prior to hysterectomy. But it's expensive and insurance will make you jump through bureaucratic hoops to get it. After getting the shot, I felt kind of weird. Then I had one last awful period blowout a few days later. Since then, no periods. Menopause symptoms included hot flashes, brain fog, mild acne, some moodiness and irritability. However I think a lot of this can be worked around with good nutrition, exercise, breathable clothing, meditation.”

8 / 10
Was this helpful?YesNo
Screw cancer · Taken for 6 months to 1 year October 13, 2020

Eligard (leuprolide) for Prostate Cancer: “Husband got Eligard shot to minimize size of prostate to prepare for radiation with 6 month follow up. When he returned the cancer had spread to his bones and PSA went from 32 to 182 in those 6 months with no additional PSA tests given. The shot was ineffective and we were not informed that it could metastasis to other body parts giving us a choice of a different treatment that would not limit his life.... Demand monthly PSAs!!!”

1 / 10
Was this helpful?YesNo
Anonymous August 6, 2010

Lupron Depot (leuprolide) for Uterine Fibroids: “I can't say enough about how glad I am that I was given Lupron injections! I was being treated for heavy non-stop bleeding caused by the several large fibroids I had. I was told by 3 different Doctor's that I would definitely need to have a hysterectomy. I really had no other option. My OBGYN and the surgeon, started me on the Lupron injections 4 months ago to stop the bleeding (I had become extremely anemic and couldn't have the surgery until my blood counts came back up which would take 3 months) and to try and shrink the fibroids. After my 4th and final shot 2 weeks ago, my MRI showed that the fibroids had shrunk 75% and my surgeon discharged me today saying that I will NOT be having a hysterectomy, nor any surgery! Thank you Lupron.”

10 / 10
Was this helpful?YesNo
Jensey37 · Taken for 1 to 6 months February 13, 2020

Lupron Depot (leuprolide) for Endometriosis: “I feel like I’m one of the few people who has had a POSITIVE experience on the medicine Lupron . I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine are minor hot flashes!! I can’t believe it. This medicine has been a blessing.”

10 / 10
Was this helpful?YesNo
mdo333 January 4, 2012

Lupron (leuprolide) for Prostate Cancer: “Had 1st shot 11/10/11, PSA was at 182, tested 3 weeks later, PSA had dropped to 3.3. Have prostate, metastatic bone and lymphatic cancer. This combined with radiation therapy, greatly improved my mobility (pelvis, hips fully involved, as well as on and inside spine). Side effects are hot flashes and night sweats, but other than that manageable for the relief I've gotten.”

8 / 10
Was this helpful?YesNo
mrm26 August 2, 2016

Lupron Depot (leuprolide) for Uterine Fibroids: “I had a fibroid that had grown into my uterine cavity and it caused heavy bleeding, large blood clots, and discomfort. I had surgery scheduled in June of 2016 and was given a Lupron injection in March of 2016 to shrink the fibroid to make surgery easier. I had read terrible reviews and was scared of the side effects. Overall my experience was very positive, I had minor side effects such as hot flashes and migraines. I am in my mid-twenties and very active, which I believe helped. No weight gain or hair loss. I felt great throughout the 3 months and actually felt more mentally and hormonally balanced then ever before...I'm actually kind of upset it has worn off! Don't be afraid of this drug, it worked wonders for me!”

10 / 10
Was this helpful?YesNo
WWII Vet · Taken for 6 months to 1 year February 18, 2015

Lupron (leuprolide) for Prostate Cancer: “Have been getting monthly Lupron 7.5 mg injections since July 2014 (just had my 8th injection). No hot flashes; some mood swings and I recently started having arm and leg cramps a few times a week. Taking Casodex 50 mg daily as well, so it's hard to know which to blame. PSA was 205 when I started these meds and is now 0.03. I believe the complete lack of hot flashes may be due to receiving the monthly vs 3 or 6-month injection dose. I hope this information helps others.”

9 / 10
Was this helpful?YesNo
Sarah2016 January 2, 2016

Lupron Depot (leuprolide) for Endometriosis: “Don't let the online reviews cheat you out of a better life! I actually delayed getting Lupron by a year because I was so scared by the online reviews and reports of adverse reactions/symptoms. However, my experience was wonderful. My doctor put me on the ad-back and I did have a FEW hot flashes initially, but I would take those 1,000x over the pain my endometriosis caused me. I also took calcium to offset any bone density loss. Please, Please, Please work with your doctor to decide if Lupron is right for YOU. I did it and now I am on my way to restoring my quality of life.”

9 / 10
Was this helpful?YesNo
Jean · Taken for 1 to 2 years April 24, 2019

Eligard (leuprolide) for Prostate Cancer: “Been taking Eligard for 5 X every 3 months, just over a year. Prostate out 10 years ago. Radiation 45x about 6 years ago. Eligard effective at reducing PSA. Occasional hot flashes. Tire easily. Often light headed. Little tolerance for BS. More headaches. Breast enlargement. Thinking about stopping use.”

4 / 10
Was this helpful?YesNo
Tom 627 · Taken for 1 to 6 months May 25, 2019

Eligard (leuprolide) for Prostate Cancer: “Been on Eligard for two months and it has taken all the joy out of life. There will be no second injection. My life expectancy is better with cancer than with Eligard and I'm fighting such dark thoughts almost everyday, afraid I'm going to hurt someone, the mood swings are unpredictable and scary. Sex is becoming near impossable all the time.”

Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.