Leuprolide for Endometriosis User Reviews

• Sarah
• January 2, 2016

Lupron Depot (leuprolide) "Don't let the online reviews cheat you out of a better life! I actually delayed getting Lupron by a year because I was so scared by the online reviews and reports of adverse reactions/symptoms. However, my experience was wonderful. My doctor put me on the ad-back and I did have a few hot flashes initially, but I would take those 1,000x over the pain my endometriosis caused me. I also took calcium to offset any bone density loss. Please, please, please work with your doctor to decide if Lupron is right for you. I did it and now I am on my way to restoring my quality of life."

• Jensey
• Taken for 1 to 6 months
• February 13, 2020

Lupron Depot (leuprolide) "I feel like I’m one of the few people who has had a positive experience on the medicine Lupron. I’ve been pain-free from my endometriosis for 3 months, now on my third dose. After my first dose, I had some joint pain and severe hot flashes for a couple of weeks, but those symptoms lessened as time went on. My mood has changed for the better while on this medicine, I no longer have pain from the endometriosis, and my only symptom from this medicine is minor hot flashes! I can’t believe it. This medicine has been a blessing."

• Lindz
• Taken for less than 1 month
• September 30, 2018

Lupron Depot (leuprolide) "I’m a 24-year-old female who’s suffered from terrible endometriosis pain; my periods left me crumpled up on the ground, moaning in pain to the point that I seriously wished I were dead. I am not exaggerating in the slightest. Sometimes I’d get really dizzy and hear an intense buzzing in my ears right before I almost passed out. The pain was unbearable; I often had to miss school and work because of my period. I recently underwent surgery and was recommended Lupron. I read horrible reviews about it for weeks leading up to my doctor appointment and was terrified to try it, but so far I haven’t had any problems other than hot flashes (and that’s MUCH preferable to the agonizing pain I used to be in). Of course, it’s only been a few months since I got the injection, so we’ll see...but so far it’s been great! Don’t let the reviews scare you; if you’re in good health like I am, you probably won’t experience serious complications or side effects. Hope this helps!"

• Ambear
• November 2, 2015

Lupron Depot (leuprolide) "I have been taking this for 6 months now, about to start my 7th, and I love it! I will say the first month or so, I was really wondering what I had gotten myself into. But now, I am so glad I did it. I take the 1-a-month, not the 3-month shot. I haven't had a period in 5 months, and I haven't cramped in 5 months. I was having hot flashes before I started taking this, and I will say that at times they are way worse, but I would much rather deal with hot flashes than be huddled over in my bed because the cramps are so bad that I can't even function. I do understand that some people have bad experiences with things, and some people don't. It is all up to your body. Everyone's body is different. I hope seeing a good review like this will help."

• LJonesL
• December 15, 2014

Lupron Depot (leuprolide) "I was diagnosed with Stage 4 endometriosis and was prescribed Lupron. After reading all of the horrible reviews and side effects, I was terrified to try this. After chatting with my doctor, we both agreed that this would be the most aggressive treatment as my husband and I would like to get pregnant one day. I am on month 3 of the shot, and I have to say that I am pleased. The worst thing are the hot flashes. For me, they are at least 10 times a day! But I will take that over the excessive cramping and pain any day. I feel minor cramps occasionally during the time I would normally have my period. I have experienced no depression, weight gain, weight loss, bleeding, joint pain, etc. I am hoping after the treatments I will be able to conceive."

• amaya
• Taken for 1 to 6 months
• November 19, 2012

Lupron Depot (leuprolide) "I started Lupron about a month ago. I started taking it after the doctor told me I had stage 1 endometriosis. About a year before, I found out I had PCOS, which caused me to gain a lot of weight, about 23 lbs. Since I've been on Lupron, I've been feeling so much better, and I've lost 7 lbs! The only thing I have been struggling with is the hot flashes. Other than that, I've been doing very well on the shot."

• Endo...
• Taken for 1 to 6 months
• September 24, 2014

Lupron Depot (leuprolide) "Stage 4 endometriosis. I've been on Lupron for 3 months and will get another injection next week. I've had a few hot flashes, about 1x/day occasionally, but not every day. I have stayed below my original weight by about 5 lb. Some moodiness/occasional depression. But overall, I haven't had any major problems! I was very worried about side effects before starting Lupron, but am glad I did it. I want to be healthy! I'm getting married next weekend also, so have been planning a wedding at the same time. We're hoping to get pregnant next year!"

• cdawhg
• November 13, 2015

Lupron Depot (leuprolide) "I really feel it is important to share my experience with this drug. I did extensive research before making my decision to start the Lupron Depot pack. I was scared, and I prayed to have a good experience since most reviews for this drug are awful. I am grateful to be able to give this drug TWO THUMBS UP! I am taking one-month shots combined with the add-back pills. The first month, I experienced NO increase in symptoms. I bled for the first month and a half, now my constant bleeding is gone! For the first month, I experienced very mild hot flashes, now none at all. My quality of life is 110% better, and I am pain-free. I am so grateful I took a chance on this medication. I finally got a break from the constant pain and exhaustion from endo."

• 1Sweet
• Taken for less than 1 month
• January 29, 2014

Lupron Depot (leuprolide) "I was on Lupron for 6 months back in 09. The side effects weren't bad for me at first, but I have to say the night sweats were the worst! I just hated waking up in the middle of the night, needing to shower because I was so sweaty. However, I was pain-free! I had an AWESOME summer and went camping, mountain biking, traveling. My pain has slowly come back over the years, and my (new) doctor just gave me my first shot of Lupron yesterday. I am hoping it works just as well as it did the first time. I want to be me again."

• Lexii
• October 5, 2015

Lupron Depot (leuprolide) "Don't do it! I got the 3-month shot 1 month ago and have had these symptoms so far: constant and severe pelvic pain, sharp lower back pain, pain when the bladder is full and when emptying, lots of migraines and headaches, nausea, vomiting, high anxiety, extreme fatigue, very low mood swings, loss of appetite, and insomnia. The worst symptom of all is the severe depression, I have had several thoughts of suicide. I would rather deal with just the pain than all of these together. I was told by my doctor the only symptom I would get is hot flashes, and she had only heard of success stories with this drug, that was a total lie. If you react badly with other birth controls, do not do Lupron, it's a living nightmare!"

• Not...
• Taken for 1 to 6 months
• January 22, 2015

Lupron Depot (leuprolide) "I am 37, and for the most part, have been very healthy... never pregnant and married for three years. I have had an ovarian cyst, but have been controllable. On Nov. 9, 2014, I went to the ER, and the next day I was having a mass and 6' of my colon removed due to endometriosis. I had stage 4. My OBGYN suggested this shot. I read all the reviews and was VERY leery of starting it, but I just took my second shot. It has not been so bad. I have experienced hot flashes and weight gain. I have about 4-6 hot flashes a night, but no sweats yet. I am hungry ALL the time, and it seems the more I eat, the more I want. I can't seem to get full. I have gained 10 pounds in about 6 weeks. My mood has been good, though. I have had to start Osphena due to side effects."

• Mindd...
• Taken for 1 to 6 months
• January 28, 2020

Lupron Depot (leuprolide) "I had 2 injections of this ruinous dangerous drug - Lupron! 1. NEVER use if have PMDD or PMS! Thyroid disease. Or serious mental issues after child birth aka manic depression. My gracious Dr by passed all the contraindications!! I have spent the past 26 years in an unimaginable state of severe fear! I was diagnosed with hypothalamus, adrenal, and digestive exhaustion. I had to have food supplements to survive! This drug will ruin your MIND! Get a hysterectomy instead!!! It can't cure endometriosis!!!! Get on bio identical hormones after wards! You'll be feeling BETTER WITHOUT uterus, and be able to go on! PLEASE PLEASE do NOT let ANYONE talk you into using this brain altering destroyer! You will NEVER have your full sanity!"

• MoMoMo
• Taken for 1 to 6 months
• May 6, 2020

Lupron Depot (leuprolide) "I was put on Lupron Depot for three months for endometriosis. I received an injection every month. My treatment started in January and ended the first Saturday in March 2020. The side effects weren't all that bad. I got my period on my dose, but it eventually went after that. I had, however, severe headaches that made me dizzy, experienced some mood changes (mostly anger), painless sex, hot flashes (manageable), and joint pains at the end of my last shot. The joint pains are mostly in my knees and fingers, but I only experience those after waking from a nap. Once I get up and start moving about, they disappear. I now await my cycle to return. It has been eight weeks since my last injection, and signs of my period returning are back. I'm spotting and experiencing mild cramps. All in all, my experience wasn't bad. Hope this helped someone. Oxoxox"

• Kris
• February 18, 2020

Lupron Depot (leuprolide) "Ok y’all I admit before taking Lupron Depot 11.25 Mg 3 month injection; I read every review I could find. I was disappointed to find mainly negative reviews but I took a leap of faith and decided to get the injection anyway. Within the first month I truly regret that decision. In tough situations I typically look for the silver lining. However I was not prepared for the extreme fatigue (No more 5am workouts), hot flashes all day every day, night sweats that literally leave my side of the bed soaked (it’s totally gross), but the topper is body aching and hurting down to my muscles and bones like I have the flu...every day going on 63 days straight. I am 38 yrs old, good shape, active when I started the injection I was 115lbs, I am now 130lbs with no energy. Needless to say I am declining the 2nd treatment and look forward to 2-6 months when all of the side effects should fully wear off and hopefully get my normal life back."

• Tired...
• Taken for 1 to 6 months
• February 17, 2019

Lupron Depot (leuprolide) "This made my pain much worse. It is the worst experience I've ever had with a medication! The side effects are much worse than the endo pain! This medicine shouldn't be given to women for endo! I have been in the worst pain and depression that I've ever had in my entire life thanks to this medication."

• Rayvan
• June 25, 2015

Lupron Depot (leuprolide) "Worst mistake of my life! I had one 3-month shot when I was 17, and I'm still regretting it (I'm 21 now). I was pretty much paralyzed while on it. I couldn't move on my own. I needed help to even sit up in bed. I missed so much school/work and cried almost all day, every day. I was in so much more pain. I was constantly sick (vomiting, nausea, painful bowel movements, headaches, joint pains), and the menopause symptoms were absolutely crazy. I still, to this day, have stomach issues I didn't have before. I have bone density loss as well. I will never recommend this drug to any woman. It is not meant for us."

• Anonymous
• December 27, 2009

Lupron (leuprolide) "I just finished my 3-month course of shots. The first two months were not too bad, but the third month has taken its toll on me. I can deal with the hot flashes, but the joint pain has become very intense. The pain is disruptive, where my hands are aching all the time. It keeps me up at nighttime, and then lack of sleep becomes a problem. I wish they would suggest a joint therapy program for you to take if you need it because it's not like you can just call up your doctor and see him right away."

• Seele...
• Taken for 1 to 6 months
• June 27, 2016

Lupron Depot (leuprolide) "I would like to address women who already struggle with depression, insomnia, or mood disorders, like myself. If you're already bad off, don't do this to yourself, it might be the final 'push.' I got the 3-month shot (+add-back), and it made me suicidal. My moods went from extreme anger to sobbing, insomnia, hot flashes, and my left arm kept going numb in daily activities! This went on for a month, at 2 months, I leveled out. Not far into the 3rd month, the hot flashes came back, cold sweats (felt like drug withdrawal), and my pain was back! I went to my OB/GYN 1 week early because of this to find I had grown 11 new painful cysts! It didn't even work, and to stop it is also unpleasant (withdrawals). Worst med decision I ever made! HELL!"

• Britt
• Taken for 6 months to 1 year
• March 27, 2018

Lupron Depot (leuprolide) "Honestly, I was so sick of having surgeries constantly, so my OB recommended trying Lupron for my endometriosis - 1 shot once a month for 6 months and longer if I would like to. I was told I couldn't have any more babies. I had tried everything, and nothing worked to have another. I got on Lupron for my extreme pain from endo, and for the first month, I got a horrible, period-like period, then after that, I didn't have a period. When I got off it, I was prego and didn't even know. I got my rainbow miracle baby, thanks, Lupron, and my endo hasn't returned since then, thank goodness. Yes, hot flashes, being sick in the morning, tired a lot because I couldn't sleep, and mood swings from hell was all worth it. I will definitely be back on this if my endo comes back!!!! Definitely a 10-star review from me! (I stayed on Lupron for 9 months)."

• 23...
• Taken for 1 to 6 months
• November 18, 2013

Lupron Depot (leuprolide) "I'm on day 48 of treatment and had my second shot on 11/04/2013. With the first shot, I bled 2 weeks prior and another 3 weeks after. After that, I haven't bled since. I'm being treated for lifelong (23 years) endometriosis. I have been disabled since 13 years old because of it. The only symptom I have had is severe non-stop hot flashes. I will have a hysterectomy in December."

• usern...
• February 1, 2012

Lupron Depot (leuprolide) "I was actually on Lupron Depot for 18 months. My periods stopped within a week, and my pain was gone within the first month. I almost didn't go on it because of the horror stories I read online, but I'm glad I did. My skin broke out more than normal, but nothing a little makeup couldn't hide. The hot flashes were intense at first, but slowly started to subside. After six months, they completely stopped. I also fully understand night sweats. The side effects were well worth it to me since I no longer have cramps that hurt so badly I pass out. I am also enjoying being period-free after never having a regular cycle and being anemic the better part of my life."

• Angel
• Taken for 1 to 6 months
• February 28, 2018

Lupron Depot (leuprolide) "I was diagnosed with stage 4 endometriosis in April of 2017. My situation was a little different because the disease went into my colon and shut down my bowel system. After two surgeries, my doctor recommended I go on Lupron for 6 months. After reading the reviews, I told my doctor no. I was scared out of my mind. He insisted and I finally agreed. I just took my last shot of my 6mo treatment, and in the beginning, I experienced the hot flashes, but I was given Northein pills to offset it, and it worked. I didn't bleed; I occasionally had sweats, nausea, or an upset stomach. However, I can't say anything really bad about the drug. I'm glad I took it. I think it depends on the individual body, but I will say you have to give your system time to adapt to the drug."

• Mom...
• Taken for less than 1 month
• November 11, 2013

Lupron (leuprolide) "My daughter (19) was given Lupron immediately after surgery to remove endometriosis. The doctor came to us right as she was in recovery and said she was giving her Lupron to suppress the cause. No explanation of side effects... how I regret it. She had to leave college... and the pain, weight gain, lack of concentration, etc. have been traumatic for us all. It takes YEARS to get this out of your system! I regret EVERY day that I let this happen to my daughter. I should have asked the questions, but I trusted the doctor."

• Teeel...
• Taken for 1 to 6 months
• February 10, 2020

Lupron Depot (leuprolide) "The depo has been great for me! At the end of my 3 month shot and the only major side effect I have are the hot flashes (which are controllable). I haven’t had a period, haven’t been moody, minimal weight gain!"

• Chann...
• September 6, 2011

Lupron Depot (leuprolide) "I LOVE LUPRON. I have stage 4 endometriosis, and Lupron has been AWESOME. I have only had one side effect: hot flashes, which I do not mind at all, they only come twice a day and last for up to 2 minutes. Hopefully, my husband and I can have intercourse without pain. I'm 23 years old."