Leuprolide for Endometriosis User Reviews (Page 5)

• LORA...
• December 4, 2019

Lupron Depot (leuprolide) "I've finished my third cycle of lupron for endometriosis and it kicked my butt ! Each cycle includes an injection each month, for 6 months. Once I finish Lupron, I slowly have periods and each month the pain gets stronger. Last time was bad, but nothing like this. There's no way of describing it other then "Roid rage", I couldn't control my emotions. 2 1/2 months I was manic, I'm talking fighting fits of rage and sobbing on the floor. which is nothing like myself, I'm almost emotionless. Hot flashes, hair thinning, loss of sex drive. That last one which I hope doesn't affect you, surprisingly is one of the worst. Gained 30 lbs over 6 mths while dieting, Even with an extremely strict diet I have only managed to loose 2 pounds and it's been 2 and a half months since my last injection. All in all I'm not sure if I will go through another treatment of Lupron as all the side effects that affected me seem to get more intense each time."

• Anonymous
• April 25, 2011

Lupron Depot (leuprolide) "I was diagnosed with endometriosis after having a laproscopy. I started the Lupron shots not long after the surgery. While the symptoms seemed to fade, the side effects were terrible. I had unbearable mood swings which caused many problems in the family. The hot flashes were ridiculous. I also ended up gaining about 20 pounds within six months. The pain did subside and I have not had as much pain since I finished the injections 10 months ago."

• Jay
• Taken for 1 to 6 months
• June 28, 2020

Lupron Depot (leuprolide) "I was put on this medication after laparoscopic surgery to remove cysts that was causing me pain. They found out I have stage 2 endo and recommended the lupron with the acetate pill. The first month was fine but the second month my period came early and never stopped. I can deal with the hot flashes but I've currently been bleeding and cramping for 4 weeks and they just keep telling me to wait it out. I'm due for the 2nd shot in July and idk if its going to help at all. I am depressed and the night sweats are a lot to deal with. I would rather have dealt with the endo pain 2 days a month than to have done this."

• emano
• October 17, 2019

Lupron Depot (leuprolide) "Using Lupron depo for endometriosis. Have an injection once a month, have just had my third injection. Missed period by 2 weeks so hopefully no painful period this month. I have had my last two periods but they were nowhere near as painful as the ones I used to suffer with. I am experiencing hot flashes, quite regularly but they only last 10/15 minutes so it’s something I can cope with and also I am going through stages of feeling quite anxious and depressed but hopefully these symptoms subside and this injection helps me for the future as I’ve recently spoken to my doctor who said this will help fertility in the future as I am 20 and have always wanted children something I thought was just going to be a dream when first diagnosed and had my fallopian tube removed at 17."

• JudiLT
• June 23, 2011

Lupron Depot (leuprolide) "Just finished three shots of Lupron Depot - shots were given in the hip - little to no pain at all. The worst side effect = hot flashes. They were unbearable really, was prescribed the lowest dosage of estrogen medicines for the hot flashes - working great. Doctor not giving any more shots of Lupron until we see how my body reacts to the medicines. I was just prescribed a progesterone as well to balance with the estrogen medicines-to take for a two week period."

• Alexis
• August 18, 2017

Lupron Depot (leuprolide) "I'm on the 6 month therapy treatment and I got my 4th injection yesterday. At the beginning I was getting the hot flashes which I can deal with, the mood swings. I rather deal with that then the terrible belly button pain , bleeding from navel and chest pain. I was diagnosed with endo stage 4 about 3 years ago. But now I'm starting to think "is it worth it?" with the insomnia, tiredness, diarrhea and waking up with migraines"

• Miss...
• July 12, 2015

Lupron (leuprolide) "I've been on lupron twice in 6years. The first time was 2008 & I didn't experience any symptoms. I was extremely happy about that. Like most of you reading all the side effects had me a little on edge. The second time my doctor suggested that I get on it (Dec2014) I agreed with no problem.. Hoping that will be the same experience as the first time.... Ohhhhhh but it wasn't, I had hot flashes, night sweats & weight gaining. I couldn't wait until those 6months were over.. Unlike the first time 3 months off lupron my cycle started & 2weeks later two cyst 7.5cm... I was devastated & in so much pain & b4 you knew it I was having surgery.. I'm 2days fresh out the hospital on lupron again... I pray this time I have a different outcome."

• Anonymous
• Taken for 1 to 6 months
• April 5, 2018

Lupron Depot (leuprolide) "Within one week of starting depot lupron, I was struck with severe headaches and fatigue. Muscle and joint pain set in and sleep became impossible. I have had no relief from my endometriosis pain. Pelvic pain is daily and constant. Dull aches in my lower abdomen and sharp shooting pain through my colon. Even with add back therapy, I have had hot flashes and severe waves of nausea, vomiting and diarrhea. I wish I had never gotten it. This is the second time my doctor has put me on this "medication" with zero results or relief from my symptoms. I only feel worse. It has made me and my relationship suffer. It's not worth it."

• Anonymous
• April 26, 2012

Lupron Depot (leuprolide) "Got first shot Jan 2012. Side effects night sweats, hot flashes, headache and muscle ache all bearable but hot flashes have interfered with sleep. Just got 2nd shot this wk 4-24-12. Have sore throat and headache, seem to be more agitated and irritable. Hot flashes are a bit worse and headaches are coming back . Overall if this is the jist of side effects all worth it to make sure cancer if spread does not come back. Had hysterectomy Nov 2011 and found cancer in uterus. Drs said it was contained to uterus but for safety precautions put me on Lupron."

• Miso
• Taken for 1 to 6 months
• January 7, 2021

Lupron Depot (leuprolide) "After a laparoscopic surgery and an 84 day heavy, heavy period, I started Lupron. The first two weeks were not great. My bleeding stopped and then started again but it was more like an ordinary period. I saw an increase in migraines during these first two weeks but I saw a significant reduction in migraines after that. I have zero complaints about the intervening 10 weeks. I’ve been period free, pain free, side effect free. I can’t remember the last time I felt that good. I’m due for another three-month injection in a week. In the last couple of days, I’ve started to have cramps and daily migraines. I’m very much looking forward to getting another dose!"

• ahann
• April 2, 2017

Lupron Depot (leuprolide) "I was diagnosed with endometriosis when I was 16, started 6 month (6 injection) Lupron therapy at 17 and felt amazing. Yes, I gained weight and got the hot flashes, depression and swelling legs and feet, but it was all worth making the pain go away. Fast forward 5 years, and endometriosis is back with a vengeance plus I had a golf-ball sized cyst on my ovary. So I had the lap to have the endo burned out and the cyst removed, and of course the next step was up to me and I begged for Lupron! Sadly, I've been let down the second time around. Symptoms are all the same but now the pain is still persistent, even in my 6th month. Major sad face about that."

• kheff
• October 22, 2009

Lupron Depot (leuprolide) "I just had my second shot 6 days ago. I will admit that my pain from the endo is a great deal better than it was. I was a few days late to get my 2nd shot and could feel the symptoms coming back slowly. The side effects are miserable. I don't want to finish out the treatment. Going for a second opinion. Will be trying estradiol today, for the hot flashes, which have been the worst, at least 3 an hour, and all night long. Haven't had any weight gain so far, weight loss, probably because I am so paranoid about gaining. "

• tired...
• January 8, 2010

Lupron Depot-Gyn (leuprolide) "I found Lupron to be effective in treating my symptoms of Endometriosis, particularly painful menstruation. Lupron causes one to cease menstruating which in turn eliminates the pain associated with month to month and/or every two to four week menstrual periods. That said, I developed a raised bump at the base of my skull on the back of my neck that itched and hurt. I became dizzy and lightheaded and dealt with short term memory loss along with joint pain in my feet, mouth watering nausea, night sweats, nasal congestion, and acne. The doctor could not give me an answer about the raised bump and that scared me so I chose to discontinue treatment."

• melissa
• May 11, 2011

Lupron Depot-Gyn (leuprolide) "Been on this for 3 months. Yes it does diminish the pain, but feel terrible by the side effects. Get mood swings, hot flashes, acne and if that's not bad enough weight gain. It's like you are a whole new person and not a very nice one. I have also been feeling very depressed. I only have one more month until my surgery so I'm trying to stick it out. Best of Luck ladies."

• SherB...
• July 27, 2015

Lupron Depot (leuprolide) "A costly and largely ineffective drug. Beware discount cards that refuse to honor their promises for low co-pay and further discounts. After having one 3 month shot priced at $2,500 and feeling little to no relief from a reoccurrence of Endometriosis I ended up getting a full hysterectomy anyway."

• Anonymous
• August 10, 2009

Lupron Depot (leuprolide) "I got my first shot almost two weeks ago. I am fat, busty and generally unmotivated. I am a tiny bit nauseous almost all of the time, but it's not bad enough to prevent me from eating. More like an appetite suppressant. Other than that everything seems fine. Although I have stage 4 endometriosis, I didn't have any of the associated symptoms, except for infertility. I guess I'll find out in a year or two if it is worth it."

• Frisbee
• April 14, 2016

Lupron Depot (leuprolide) "I've only had one dose of Lupron; before going on it I did my research. One side effect is HORRIBLE insomnia (which I have). I know not every single change in my body can be blamed on the Lupron. I have Endometriosis and the Lupron basically puts you in a state of menopause. Headaches, insomnia, sweats, mood swings were very bad the first couple of weeks; now my stomach hurts! So I think I can pick and choose what the medicine is responsible for and the state of chemical menopause is doing to me."

• KBano
• Taken for 1 to 2 years
• February 3, 2020

Lupron Depot (leuprolide) "I had a very similar experience to Lora C. I was a mess on Lupron and very much not myself. I couldn't control my emotions, I was either dead inside or crying, there was no in between. My night sweats were awful and I was mean all the time. The worst part was probably my memory. I had no recollection of anyone's name, I could recognize their face and the fact that I definitely know them, but never their names if I had met them after I was on Lupron. The shot also hurts like anything and hot flashes are real. I was consistently warm all of the time. Summer was unbearable. Also, the first few months were the worst endo pain I had ever felt. It was terrible. It finally went away after about month 4 or 5 and I was in a normal range of just feeling pressure down there. It wasn't nearly as painful, but always present."

• Lilbit
• Taken for 1 to 2 years
• January 7, 2016

Lupron Depot (leuprolide) "I had been suffering for years. Horrible pain,cramps all day and night and meds NEVER took the severe pain away. The bleeding was excessive. Never had a light day. My period lasted for a month sometimes almost 2months. At the age of 15,I was taken to the gyn which at that time was diagnosed with ovarian cysts and a bad case of endometriosis. Not only was the cysts bad but the endometriosis had grown all over my ovaries, in my belly button and was making it hard for me to move my bowels. The doctor politely said well you have a bad case here and you need surgery so I said ok well when, and he said TOMORROW. So surgery happened and not even 6months later I was having surgery again. I'm 34 and its all back"

• Tripp
• Taken for less than 1 month
• April 21, 2018

Lupron Depot (leuprolide) "I just started the lupron shot and so far its helping but its also come along with hot flashes , dizzyness, prolonged QT heart interval (I already have the heart problem but it is amplifying it) body pain which is slowly going down, brain fog, insomnia, fatigue inability to breathe, and is making some of my connective tissue symptoms worse. I'm hoping at least some of these symptoms go away. If they do I will continue the monthly shots since the endo symptoms are getting better (headache, bowel issues, insane amount of bleeding every month and debilitating pain)."

• Angmtt
• Taken for 1 to 6 months
• October 24, 2016

Lupron Depot (leuprolide) "Started almost a month ago, I just got over my period when I recieved the injection, I started my menses about week and half after injection, they said this is normal, overall pain is a tad worse, the drs also said that would happen, I'm not giving a full rating on it yet, I haven't been on it long enough, they are trying to shrink a 3 inch abdominal wall endometriosis, I will have to stay on the drug for a year, also been prescribed norethindrone, haven't really had the side effects listed with this drug, not sure I will later on or not."

• EC449
• Taken for 6 months to 1 year
• May 29, 2018

Lupron Depot (leuprolide) "I am 25 and received 9 months of injections with Lupron for endometriosis and had a terrible experience with it. First was the symptom flare the first month which made my pain even worse and I missed 3 weeks of work out of 4 weeks. Then even with add back therapy, I had hot flashes, trouble sleeping, severe pain with sex, and bad acne. And it did nothing to help the pain I was having. I stopped this medication after 9 months and even now, one year after stopping, I have residual digestive issues and continued vulvodynia which started when I was on Lupron. Many doctors seem to use this drug as a first line treatment against Endo but it is brutal and is only a temporary treatment"

• DeeDee
• August 14, 2015

Lupron Depot-Gyn (leuprolide) "I began a 6 month course of lupron with add back therapy in January 2015. I was terrified from everything I've read online. I had none of the horrible side effects, some hot Vosges here and there, but nothing unmanageable. I am a 41 year old female with endometriosis. I was pain free for the entire six months and felt good. Everyone is different, but with so many negative comments about thus therapy flooding the Internet, I thought it might be helpful to add my 2 cents."

• C135
• Taken for 1 to 6 months
• September 4, 2020

Lupron Depot (leuprolide) "I was given a Lupron Depot 3month injection. The day after the injection I was in debilitating pain in my spine my hands & wrists & my ankles & it only got worse from there. The pain worsened as the days went by, I had trouble getting up I was drained of all energy was nauseated pain & stiffness in my hands & wrists to the point I could barely move them. I had horrible painful popping & cracking in my wrists & ankles & they would lock up & felt as though my bones were going to break. I had horrific migraines too. When I called my doctor regarding this effects they said it'd go away after the trial ended. It's over 6 months since I had my trial, & the pain & stiffness in my hands & wrists didn't go away. I now have tingling & weakness that spreads through my hands, wrists & arms. I had the laparoscopic surgery last month & I do have endometriosis. I just wish I'd done the surgery to begin with."

• Sidney...
• February 16, 2016

Lupron Depot (leuprolide) "When I took this it was very painful. The shots messed up my muscles and my condition got so much worse after the 6 month period. I had to get surgery and lost my first organ. I'm not saying don't try it for endo but be wary when you do. You're supposed to have more intense symptoms in the first part but it is supposed to get better. Mine did not, it only got worse."