Leuprolide for Endometriosis User Reviews (Page 5)

• Ren...
• May 28, 2018

"I personally have endometriosis and have had laparoscopic surgery for treatment. I have been told by multiple doctors that adding hormones to your body to lessen your “pain” (in quotes because no birth control has proven to do so for my endometriosis), so I have taken no birth control since my surgery 10 years ago, and it has gotten easier to deal with, not worse! They also offered two other options to stop the pain: hysterectomy/ablation. Either way would be fine since endometriosis will and has eaten up my reproductive organs. After the laparoscopic surgery, it did take me 5 months to heal internally, so if you do this option, please prepare yourself for a much, much, much heavier and DIFFERENT period for at least the first two months. But after, sex seemed easier with less pain, and going to the bathroom (taking a bowel movement) while on and off my period was much easier. Hope my experience helps anyone that has or has been recently diagnosed."

• Anonymous
• April 7, 2012

"Had my first shot about a week ago. I have major pain in my joints (elbows and knees), hot flashes, and night sweats. But honestly, so far, so good. I am no longer feeling the horrible endometriosis pain. Will update more once I'm further in. Plan as of now is to do 6 months of Lupron and see if my fallopian tubes have less swelling and inflammation, as my husband and I would love a baby of our own. Good luck to all. This is not easy. But I am hoping it will be worth it."

• Mon...
• September 18, 2016

"I was diagnosed with ovarian cysts and endometriosis at 18 years old (very early to find). I've suffered 4 years of this before I got diagnosed until eventually I was rushed to the hospital from the pain. My only option was Lupron Depot shot, I got the 11 mg one. Worst decision of my life. I am thankful for having 100% coverage because it would've been a waste of money. I feel sad, depressed, anxious, it's awful. I already have depression and anxiety. I feel like I'm going through withdrawals, I get heat flashes. The pills they give, what they call Norlutate, didn't help the symptoms, I've noticed they made it worse. I had headaches every single day. I wouldn't recommend this shot. I'm still having period pain, and it's been 3 months."

• tir...
• January 8, 2010

"I found Lupron to be effective in treating my symptoms of endometriosis, particularly painful menstruation. Lupron causes one to cease menstruating, which in turn eliminates the pain associated with month-to-month and/or every two to four week menstrual periods. That said, I developed a raised bump at the base of my skull on the back of my neck that itched and hurt. I became dizzy and lightheaded and dealt with short-term memory loss, along with joint pain in my feet, mouth-watering nausea, night sweats, nasal congestion, and acne. The doctor could not give me an answer about the raised bump, and that scared me, so I chose to discontinue treatment."

• aha...
• April 2, 2017

"I was diagnosed with endometriosis when I was 16, started 6 months (6 injections) of Lupron therapy at 17, and felt amazing. Yes, I gained weight and got the hot flashes, depression, and swollen legs and feet, but it was all worth making the pain go away. Fast forward 5 years, and endometriosis is back with a vengeance, plus I had a golf-ball-sized cyst on my ovary. So I had the lap to have the endo burned out and the cyst removed, and of course the next step was up to me, and I begged for Lupron! Sadly, I've been let down the second time around. Symptoms are all the same, but now the pain is still persistent, even in my 6th month. Major sad face about that."

• Anonymous
• Taken for 1 to 6 months
• April 5, 2018

"Within one week of starting Depot Lupron, I was struck with severe headaches and fatigue. Muscle and joint pain set in, and sleep became impossible. I have had no relief from my endometriosis pain. Pelvic pain is daily and constant. Dull aches in my lower abdomen and sharp shooting pain through my colon. Even with add-back therapy, I have had hot flashes and severe waves of nausea, vomiting, and diarrhea. I wish I had never gotten it. This is the second time my doctor has put me on this 'medication' with zero results or relief from my symptoms. I only feel worse. It has made me and my relationship suffer. It's not worth it."

• Mis...
• July 12, 2015

"I've been on Lupron twice in 6 years. The first time was 2008, and I didn't experience any symptoms. I was extremely happy about that. Like most of you reading, all the side effects had me a little on edge. The second time my doctor suggested that I get on it (Dec 2014), I agreed with no problem. Hoping that will be the same experience as the first time. Ohhhhhh, but it wasn't. I had hot flashes, night sweats, and weight gain. I couldn't wait until those 6 months were over. Unlike the first time, 3 months off Lupron, my cycle started, and 2 weeks later, two cysts, 7.5 cm. I was devastated and in so much pain, and before you knew it, I was having surgery. I'm 2 days fresh out of the hospital on Lupron again. I pray this time I have a different outcome."

• Mis...
• Taken for 1 to 6 months
• January 7, 2021

"After a laparoscopic surgery and an 84-day heavy, heavy period, I started Lupron. The first two weeks were not great. My bleeding stopped and then started again, but it was more like an ordinary period. I saw an increase in migraines during these first two weeks, but I saw a significant reduction in migraines after that. I have zero complaints about the intervening 10 weeks. I’ve been period-free, pain-free, side effect-free. I can’t remember the last time I felt that good. I’m due for another three-month injection in a week. In the last couple of days, I’ve started to have cramps and daily migraines. I’m very much looking forward to getting another dose!"

• Rob...
• November 13, 2016

"So I had bad adverse effects to the Depo Provera shot. So bad that I lost my job. I had bad fevers for 6 months. It felt like my body was on fire. No energy, and it triggered hypothyroidism in me. I'm only 37. I have finally gotten to feeling better, the shot is out of my system as of a couple weeks back, and I'm losing weight now. No period yet, but my gyno said the next thing he could do is Depo Lupron. Needless to say, I'm terrified! It's only the monthly shot, but I'm still scared to death. I already suffer from mental illness. I just wanted a hysterectomy to get this nightmare over with so I could get back to life and never worry about this crap again. If you have any insight, let me know. Thanks."

• mel...
• May 11, 2011

"Been on this for 3 months. Yes, it does diminish the pain, but feel terrible by the side effects. Get mood swings, hot flashes, acne, and if that's not bad enough, weight gain. It's like you are a whole new person and not a very nice one. I have also been feeling very depressed. I only have one more month until my surgery, so I'm trying to stick it out. Best of luck, ladies."

• Jud...
• June 23, 2011

"Just finished three shots of Lupron Depot - shots were given in the hip - little to no pain at all. The worst side effect = hot flashes. They were unbearable, really. Was prescribed the lowest dosage of estrogen medicines for the hot flashes - working great. Doctor not giving any more shots of Lupron until we see how my body reacts to the medicines. I was just prescribed a progesterone as well to balance with the estrogen medicines - to take for a two-week period."

• C13...
• Taken for 1 to 6 months
• September 4, 2020

"I was given a Lupron Depot 3-month injection. The day after the injection, I was in debilitating pain in my spine, my hands, my wrists, and my ankles, and it only got worse from there. The pain worsened as the days went by, I had trouble getting up, I was drained of all energy, was nauseated, and had pain and stiffness in my hands and wrists to the point I could barely move them. I had horrible, painful popping and cracking in my wrists and ankles, and they would lock up and felt as though my bones were going to break. I had horrific migraines, too. When I called my doctor regarding these effects, they said it'd go away after the trial ended. It's over 6 months since I had my trial, and the pain and stiffness in my hands and wrists didn't go away. I now have tingling and weakness that spreads through my hands, wrists, and arms. I had the laparoscopic surgery last month, and I do have endometriosis. I just wish I'd done the surgery to begin with."

• l84...
• Taken for 6 months to 1 year
• January 2, 2016

"I was on Lupron for a year (2006-2007), and I have never felt the same. I am going on 50, but my body feels 100 years old. I was once described as a vivacious and enthusiastic individual. Today, I can barely keep up with friends and family (many of them are older than me)."

• KBa...
• Taken for 1 to 2 years
• February 3, 2020

"I had a very similar experience to Lora C. I was a mess on Lupron and very much not myself. I couldn't control my emotions, I was either dead inside or crying, there was no in-between. My night sweats were awful, and I was mean all the time. The worst part was probably my memory. I had no recollection of anyone's name, I could recognize their face and the fact that I definitely knew them, but never their names if I had met them after I was on Lupron. The shot also hurts like anything, and hot flashes are real. I was consistently warm all the time. Summer was unbearable. Also, the first few months were the worst endo pain I had ever felt. It was terrible. It finally went away after about month 4 or 5, and I was in a normal range of just feeling pressure down there. It wasn't nearly as painful, but always present."

• Dee...
• August 14, 2015

"I began a 6-month course of Lupron with add-back therapy in January 2015. I was terrified from everything I've read online. I had none of the horrible side effects, some hot flushes here and there, but nothing unmanageable. I am a 41-year-old female with endometriosis. I was pain-free for the entire six months and felt good. Everyone is different, but with so many negative comments about this therapy flooding the Internet, I thought it might be helpful to add my 2 cents."

• khe...
• October 22, 2009

"I just had my second shot 6 days ago. I will admit that my pain from the endo is a great deal better than it was. I was a few days late to get my 2nd shot and could feel the symptoms coming back slowly. The side effects are miserable. I don't want to finish out the treatment. Going for a second opinion. Will be trying estradiol today for the hot flashes, which have been the worst, at least 3 an hour, and all night long. Haven't had any weight gain so far, weight loss, probably because I am so paranoid about gaining."

• Fri...
• April 14, 2016

"I've only had one dose of Lupron; before going on it, I did my research. One side effect is horrible insomnia (which I have). I know not every single change in my body can be blamed on the Lupron. I have endometriosis, and the Lupron basically puts you in a state of menopause. Headaches, insomnia, sweats, and mood swings were very bad the first couple of weeks; now my stomach hurts! So I think I can pick and choose what the medicine is responsible for and what the state of chemical menopause is doing to me."

• Ang...
• Taken for 1 to 6 months
• October 24, 2016

"Started almost a month ago. I just got over my period when I received the injection. I started my menses about a week and a half after the injection. They said this is normal. Overall, pain is a tad worse. The doctors also said that would happen. I'm not giving a full rating on it yet. I haven't been on it long enough. They are trying to shrink a 3-inch abdominal wall endometriosis. I will have to stay on the drug for a year. I've also been prescribed norethindrone. I haven't really had the side effects listed with this drug. Not sure I will later on or not."

• EC4...
• Taken for 6 months to 1 year
• May 29, 2018

"I am 25 and received 9 months of injections with Lupron for endometriosis and had a terrible experience with it. First was the symptom flare the first month, which made my pain even worse, and I missed 3 weeks of work out of 4 weeks. Then, even with add-back therapy, I had hot flashes, trouble sleeping, severe pain with sex, and bad acne. And it did nothing to help the pain I was having. I stopped this medication after 9 months, and even now, one year after stopping, I have residual digestive issues and continued vulvodynia, which started when I was on Lupron. Many doctors seem to use this drug as a first-line treatment against endo, but it is brutal and is only a temporary treatment."

• Sid...
• February 16, 2016

"When I took this, it was very painful. The shots messed up my muscles, and my condition got so much worse after the 6-month period. I had to get surgery and lost my first organ. I'm not saying don't try it for endo, but be wary when you do. You're supposed to have more intense symptoms in the first part, but it is supposed to get better. Mine did not, it only got worse."

• Anonymous
• August 10, 2009

"I got my first shot almost two weeks ago. I am fat, busty, and generally unmotivated. I am a tiny bit nauseous almost all of the time, but it's not bad enough to prevent me from eating. More like an appetite suppressant. Other than that, everything seems fine. Although I have stage 4 endometriosis, I didn't have any of the associated symptoms, except for infertility. I guess I'll find out in a year or two if it is worth it."

• Anonymous
• April 26, 2012

"Got first shot Jan 2012. Side effects: night sweats, hot flashes, headache, and muscle ache all bearable, but hot flashes have interfered with sleep. Just got 2nd shot this week, 4-24-12. Have sore throat and headache, seem to be more agitated and irritable. Hot flashes are a bit worse, and headaches are coming back. Overall, if this is the gist of side effects, all worth it to make sure cancer, if spread, does not come back. Had hysterectomy Nov 2011 and found cancer in uterus. Doctors said it was contained to uterus, but for safety precautions, put me on Lupron."

• Tri...
• Taken for less than 1 month
• April 21, 2018

"I just started the Lupron shot, and so far it's helping, but it's also come along with hot flashes, dizziness, prolonged QT heart interval (I already have the heart problem, but it is amplifying it), body pain which is slowly going down, brain fog, insomnia, fatigue, inability to breathe, and is making some of my connective tissue symptoms worse. I'm hoping at least some of these symptoms go away. If they do, I will continue the monthly shots since the endo symptoms are getting better (headache, bowel issues, insane amount of bleeding every month, and debilitating pain)."

• kai...
• Taken for 2 to 5 years
• September 26, 2017

"I've been on the Lupron shot for almost 2 years now. The first six months were the hardest. I woke up tired, icky feeling, and puked. I lost my appetite, lost a lot of weight, and it made my insomnia worse and my urge to pee worse, especially at night. Once the nausea settled and my appetite came back, the other side effects were easy to cope with on top of the side effects from the Implanon. I haven't bled at all and had no pain. I got off it for 3 months, and some of my shooting pain came back, but no bleeding, so I got put back on it. I just decided to take a break, and I'm crampy and starting to spot. My OB/GYN said I shouldn't have pain like I was before, so we shall wait and see. Since the Lupron is working, my Medicaid won't let me have a lap to see what stage my endometriosis is."

• She...
• July 27, 2015

"A costly and largely ineffective drug. Beware discount cards that refuse to honor their promises for low co-pay and further discounts. After having one 3-month shot priced at $2,500 and feeling little to no relief from a recurrence of endometriosis, I ended up getting a full hysterectomy anyway."