Leuprolide Dosage
Medically reviewed by Drugs.com. Last updated on Jun 6, 2022.
Applies to the following strengths: 7.5 mg/month; 22.5 mg/3 months; 45 mg/6 months; 30 mg/4 months; 65 mg; 11.25 mg/month; 15 mg/month; 3.75 mg/month; 11.25 mg/3 months; 30 mg/3 months; 5 mg/mL; 1 mg/0.2 mL; 7.5 mg; 3.75 mg; 42 mg/6 months
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Prostate Cancer
LUPRON DEPOT:
7.5 mg IM once a month
OR
22.5 mg IM every 3 months
OR
30 mg IM every 4 months
OR
30 mg every 6 months
SUBCUTANEOUS:
ELIGARD:
7.5 mg subcutaneously once a month
OR
45 mg subcutaneously every 6 months
LEUPROLIDE ACETATE:
1 mg subcutaneously daily
Use: Palliative treatment of advanced prostate cancer
Usual Adult Dose for Endometriosis
3.75 mg IM once a month for up to 6 months
OR
11.25 mg depot every 3 months
Comments:
-In women receiving this drug for endometriosis, hormone replacement therapy is recommended to reduce bone mineral density loss and vasomotor symptoms.
Uses: Management of endometriosis (including pain relief and reduction of endometriotic lesions), preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata
Usual Adult Dose for Uterine Leiomyomata
3.75 mg IM once a month for up to 6 months
OR
11.25 mg depot every 3 months
Comments:
-In women receiving this drug for endometriosis, hormone replacement therapy is recommended to reduce bone mineral density loss and vasomotor symptoms.
Uses: Management of endometriosis (including pain relief and reduction of endometriotic lesions), preoperative hematologic improvement of patients with anemia caused by uterine leiomyomata
Usual Pediatric Dose for Precocious Puberty
IM INJECTION:
2 years and older:
ONE MONTH DEPOT INJECTION:
25 kg or less: 7.5 mg IM once a month
Greater than 25 kg to 37.5 kg: 11.25 mg IM once a month
Greater than 37.5 kg: 15 mg IM once a month
THREE MONTH DEPOT INJECTION:
11.25 or 30 mg IM every 3 months
Comments:
-Doses should be titrated to the individual.
-Hormone levels should be tested after 1 to 2 months of therapy and with each dose change to ensure adequate pituitary gonadotropin suppression.
-Once a dose that results in adequate hormonal suppression has been determined, it can often be maintained for the duration of therapy in most children; however, hormonal suppression should be verified as weight can increase significantly while on therapy.
-Therapy should be discontinued at the appropriate age of onset of puberty at the discretion of the physician.
SUBCUTANEOUS INJECTION:
2 years and older:
Fensolvi (long acting formulation): 45 mg subcutaneously every 6 months
NOTE: The short-acting formulation has been replaced with long-acting formulations.
Comments:
-The dosage should be adjusted for weight changes.
-Discontinuation of therapy be considered before age 11 for females and before age 12 for males.
Use: Treatment of children with central precocious puberty (CPP); CPP is defined as early onset of secondary sexual characteristics (generally earlier than 8 years in girls and 9 years in boys) associated with pubertal pituitary gonadotropin activation; it may show a significantly advanced bone age that can result in diminished adult height
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Pediatric patients: If adequate hormonal and clinical suppression is not reached with the starting dose, it should be increased to the next available higher dose (e.g., 11.25 mg or 15 mg at the next monthly injection).
Precautions
CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
-Hypersensitivity to GnRH, GnRH agonist analogs
-Pregnancy
Eligard; Fensolvi: Safety and efficacy have not been established in patients younger than 18 years.
LUPRON DEPOT-PED: Safety and efficacy have not been established in patients younger than 2 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-The injection site should be varied periodically.
-Avoid areas with brawny or fibrous subcutaneous tissue or locations that could be rubbed or compressed (e.g., with a belt or clothing waistband)
Storage requirements:
-The manufacturer product information should be consulted.
Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.
Monitoring:
-Metabolic: Blood glucose and/or glycosylated hemoglobin (HbA1c) periodically
Patient advice:
-This drug can influence the ability to drive and use machines.
Frequently asked questions
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- Drug class: gonadotropin releasing hormones
Patient resources
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- Leuprolide Intramuscular, Subcutaneous, Intradermal, Injection (Advanced Reading)
- Leuprolide Injection (CPP)
- Leuprolide Injection (Prostate)
- Leuprolide Injection (Women)
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.