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Supprelin LA Side Effects

Generic Name: histrelin

Note: This document contains side effect information about histrelin. Some of the dosage forms listed on this page may not apply to the brand name Supprelin LA.

For the Consumer

Applies to histrelin: subcutaneous implant, subcutaneous kit

Along with its needed effects, histrelin (the active ingredient contained in Supprelin LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:

Rare
  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain
Incidence not known
  • Bloating of the stomach
  • dark urine
  • discouragement
  • feeling sad or empty
  • irritability
  • light-colored stools
  • loss of interest or pleasure
  • seizures
  • stomach pain
  • trouble concentrating
  • trouble sleeping
  • yellow eyes or skin

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating
Less common
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • swelling of the breast or breast soreness in both females and males
  • unusually warm skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit

Endocrine

Common (1% to 10%): Elevated blood glucose, gynecomastia
Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone
Rare (less than 0.1%): Benign pituitary tumor
Postmarketing reports: Pituitary apoplexy[Ref]

Cardiovascular

Very common (10% or more): Hot flashes (up to 65.5%)
Common (1% to 10%): Blushing
Uncommon (0.1% to 1%): Hematoma, peripheral edema
Rare (less than 0.1%): Palpitations, ventricular extrasystoles[Ref]

Local

Very common (10% or more): Implant/application site reaction (up to 51.1%)
Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain
Postmarketing reports: Implant breakage[Ref]

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.[Ref]

Other

Common (1% to 10%): Asthenia, fatigue
Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise
Rare (less than 0.1%): Wound infection, disease progression[Ref]

Psychiatric

Common (1% to 10%): Mood changes, depression, decreased libido, insomnia
Uncommon (0.1% to 1%): Irritability[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, pain in the extremities
Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia[Ref]

Dermatologic

Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis
Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis
Rare (less than 0.1%): Skin infection[Ref]

Gastrointestinal

Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Abdominal discomfort, nausea[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention
Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency
Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia[Ref]

General

Supprelin LA(R):
-The most common adverse reactions involved the implant site, including bruising, pain, soreness, erythema, and swelling.[Ref]

Hematologic

Uncommon (0.1% to 1%): Anemia[Ref]

Hepatic

Common (1% to 10%): Hepatic disorder
Uncommon (0.1% to 1%): Elevated aspartate aminotransferase
Postmarketing reports: Drug-induced liver injury[Ref]

Immunologic

Rare (less than 0.1%): Influenza-like illness[Ref]

Metabolic

Common (1% to 10%): Fluid retention, hypercalcemia, hypercholesterolemia, food cravings, increased appetite, weight gain, weight loss[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Tremor, lethargy
Rare (less than 0.1%): Migraine
Postmarketing reports: Seizures/convulsions[Ref]

Renal

Common (1% to 10%): Impaired renal function
Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance[Ref]

Respiratory

Common (1% to 10%): Exertional dyspnea
Rare (less than 0.1%): Epistaxis[Ref]

References

1. "Product Information. Vantas (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.

2. "Product Information. Supprelin LA (histrelin)." Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.

Some side effects of Supprelin LA may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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