Triptodur Side Effects

Generic name: triptorelin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 1, 2025.

Note: This document provides detailed information about Triptodur.

Applies to triptorelin: intramuscular powder for suspension, intramuscular powder for suspension 6 month Side Effects associated with triptorelin. Some dosage forms listed on this page may not apply specifically to the brand name Triptodur.

Applies to triptorelin: intramuscular powder for suspension, intramuscular powder for suspension 6 month.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.

Patients receiving triptorelin (the active ingredient contained in Triptodur) injection for advanced prostrate cancer:

• When you first start using this medicine, some of your symptoms might get worse or you might have new symptoms for a short time. Tell your doctor right away if you have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.
• Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem, such as QT prolongation.
• This medicine may cause changes in your blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.
• This medicine may increase your risk of having a heart attack or stroke. Call your doctor right away if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, nausea, sweating, trouble breathing, or vomiting.

Patients receiving triptorelin injection for central precocious puberty (CPP):

• This medicine can cause a brief increase in blood levels of some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding in girls. If your child's symptoms do not improve within 2 months, or if they get worse, call your doctor.
• Monitor your child's height every 3 to 6 months while on treatment with this medicine.
• This medicine may cause your child to be agitated, irritable, or display other abnormal behaviors. Make sure the doctor knows if your child has trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if your child has sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.
• Using this medicine may increase your child's risk of having seizures. Check with your doctor right away if your child starts to have convulsions, muscle spasm or jerking of all extremities, sudden loss of consciousness, or loss of bladder control.
• This medicine may cause intracranial hypertension or pseudotumor cerebri (increased pressure in the head) in children. Check with your doctor right away if your child has blurred or double vision, change in ability to see colors, especially blue or yellow, continuing ringing or buzzing or other unexplained noise in the ears, dizziness, eye pain, hearing loss, nausea and vomiting, or severe headache.

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Serious side effects of Triptodur

Along with its needed effects, triptorelin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking triptorelin:

For adult men

• bladder pain
• bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody or cloudy urine
• blurred vision
• chest pain or tightness
• cough producing mucus
• decrease in urine volume or frequency of urination
• difficult or labored breathing
• difficult, burning, or painful urination
• difficulty in passing urine
• dizziness
• dry mouth
• flushed, dry skin
• frequent urge to urinate
• fruit-like breath odor
• headache
• increased hunger
• increased thirst
• increased urination
• loss of consciousness
• lower back or side pain
• nausea
• nervousness
• pale skin
• pounding in the ears
• rapid weight gain
• slow or fast heartbeat
• stomach ache
• sweating
• tingling of the hands or feet
• trouble breathing
• unexplained weight loss
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight gain or loss
• vomiting

For adult men

• anxiety
• changes in skin color
• changes in vision
• chest discomfort
• cold, clammy, or pale skin
• confusion
• dizziness or lightheadedness
• fainting
• inability to speak
• irregular heartbeat
• numbness or tingling in the face, arms, or legs
• pain
• pain or discomfort in the arms, jaw, back, or neck
• pain, redness, or swelling in the arm or leg
• seizures
• severe or sudden headache
• slow heart rate
• slurred speech
• temporary blindness
• tenderness
• trouble speaking, thinking, or walking
• weakness in the arm or leg on one side of the body, sudden and severe

Other side effects of Triptodur

Some side effects of triptorelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For adult men

• bone pain
• chills
• decrease in testicle size
• decreased interest in sexual intercourse
• diarrhea
• feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
• fever
• general feeling of discomfort or illness
• inability to have or keep an erection
• joint pain
• leg pain
• loss in sexual ability, desire, drive, or performance
• loss of appetite
• muscle aches and pains
• redness of the face, neck, arms, and occasionally, upper chest
• runny nose
• shivering
• sore throat
• sudden sweating
• trouble sleeping

For adult men

• back pain
• belching
• body aches or pain
• breast pain
• burning, dry, or itching eyes
• congestion
• crying
• depersonalization
• difficulty having a bowel movement
• difficulty with moving
• discharge or excessive tearing
• dysphoria
• euphoria
• eye pain
• heartburn
• hoarseness
• indigestion
• injection site pain
• itching or rash
• lack or loss of strength
• leg cramps
• loss of appetite
• muscle aching or cramping
• muscle pains or stiffness
• paranoia
• quick to react or overreact emotionally
• rapidly changing moods
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• runny nose
• stomach discomfort, upset, or pain
• swelling of the breasts or breast soreness in both females and males
• swollen joints
• tender, swollen glands in the neck
• trouble swallowing
• voice changes
• weight loss

For healthcare professionals

Applies to triptorelin: intramuscular powder for injection, intramuscular powder for injection extended release.

General adverse events

The most common adverse events were hot flushes, impotence, decreased libido, skeletal pain, and headache.^[Ref]

Cardiovascular

• Very common (10% or more): Hot flush (73%), hypertension (14%)
• Common (1% to 10%): Dependent edema
• Uncommon (0.1% to 1%): Embolism
• Rare (less than 0.1%): Hypotension
• Postmarketing reports: Blood pressure increased, thromboembolic events including, but not limited to, pulmonary emboli, cerebrovascular accident, myocardial infarction, deep venous thrombosis, transient ischemic attack, and thrombophlebitis^[Ref]

Genitourinary

• Very common (10% or more): Impotence (40%), urinary tract infection (12%), erectile dysfunction (10%), dysuria; women: dyspareunia, dysmenorrhea, ovarian hyperstimulation syndrome, ovarian hypertrophy, pelvic pain, vulvovaginal dryness, bleeding/spotting, genital hemorrhage (including menorrhagia and metrorrhagia)
• Common (1% to 10%): Testicular atrophy, breast pain, gynecomastia, urinary retention, vaginal bleeding (children)
• Uncommon (0.1% to 1%): Testicular pain, vaginal discharge (children)
• Rare (less than 0.1%): Ejaculation failure
• Frequency not reported: Testosterone levels increased, testosterone levels decreased, worsening of urethral or bladder outlet obstruction, worsening of symptoms of endometriosis
• Postmarketing reports: Amenorrhea^[Ref]

At the beginning of treatment, endometriosis symptoms including pelvic pain and dysmenorrhea are commonly exacerbated due to an initial transient increase in plasma estradiol levels. These symptoms are transient and usually disappear in one to two weeks.^[Ref]

Psychiatric

• Very common (10% or more): Decreased libido (40%), sleep disorders, mood changes
• Common (1% to 10%): Insomnia, emotional lability, loss of libido, depression, depressed mood, irritability
• Rare (less than 0.1%): Confusional state, decreased activity, euphoric mood
• Postmarketing reports: Anxiety, affect lability, nervousness^[Ref]

Hematologic

• Very common (10% or more): Decreased hemoglobin, decreased red blood count
• Common (1% to 10%): Anemia
• Frequency not reported: Increased lymphocyte count^[Ref]

Hepatic

• Very common (10% or more): Increased AST, increased ALT, increased alkaline phosphatase, increased hepatic transaminases
• Common (1% to 10%): Abnormal hepatic function
• Uncommon (0.1% to 1%): Gama-glutamyl transferase increased
• Rare (less than 0.1%): Blood alkaline phosphatase increased^[Ref]

Metabolic

• Very common (10% or more): Increased glucose
• Common (1% to 10%): Diabetes mellitus/hyperglycemia, anorexia
• Uncommon (0.1% to 1%): Weight increased, gout, increased appetite, weight decreased^[Ref]

Renal

• Very common (10% or more): Increased BUN
• Uncommon (0.1% to 1%): Blood creatinine increased
• Frequency not reported: Worsening hematuria, decreased kidney function^[Ref]

Respiratory

• Very common (10% or more): Influenza (16%)
• Common (1% to 10%): Bronchitis, coughing, dyspnea, pharyngitis
• Uncommon (0.1% to 1%): Asthma aggravated
• Rare (less than 0.1%): Orthopnea, epistaxis, nasopharyngitis^[Ref]

Musculoskeletal

• Very common (10% or more): Skeletal pain (13%), back pain (11%)
• Common (1% to 10%): Pain in extremity, arthralgia, edema in legs, leg cramps, myalgia, musculoskeletal pain, muscle spasms
• Uncommon (0.1% to 1%): Muscle cramp, muscular weakness
• Rare (less than 0.1%): Joint stiffness, joint swelling, musculoskeletal stiffness, osteoarthritis
• Frequency not reported: Worsening of bone pain, increased bone loss, osteoporosis, bone fracture, bone disorder, epiphysiolysis, slipped capital femoral epiphysis
• Postmarketing reports: Bone pain^[Ref]

Nervous system

• Very common (10% or more): Paresthesia in lower limbs
• Common (1% to 10%): Headache, dizziness, fatigue
• Uncommon (0.1% to 1%): Tinnitus, somnolence, paresthesia
• Rare (less than 0.1%): Vertigo, dysstasia, memory impairment
• Frequency not reported: Worsening of neuropathy, spinal cord compression with weakness or paralysis of the lower extremities
• Postmarketing reports: Convulsions^[Ref]

Other

• Very common (10% or more): Asthenia
• Common (1% to 10%): Leg pain, peripheral edema, leg pain, back pain, fatigue, chest pain, edema
• Uncommon (0.1% to 1%): Lethargy, pain, rigors, blood lactate dehydrogenase increased, blood cholesterol increased
• Rare (less than 0.1%): Pyrexia, influenza like illness, body temperature increased
• Frequency not reported: Chills
• Postmarketing reports: Malaise^[Ref]

Dermatologic

• Very common (10% or more): Hyperhidrosis
• Common (1% to 10%): Rash, pruritus
• Uncommon (0.1% to 1%): Acne, alopecia, hypotrichosis
• Rare (less than 0.1%): Purpura, blister
• Postmarketing reports: Angioneurotic edema, urticaria^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity reaction
• Uncommon (0.1% to 1%): Allergic reactions
• Rare (less than 0.1%): Anaphylactic reaction, hypersensitivity
• Frequency not reported: Anaphylactic shock, angioedema^[Ref]

Local

• Common (1% to 10%): Injection site pain, injection site reactions, injection site erythema, injection site inflammation^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, constipation, dyspepsia, diarrhea, abdominal pain, abdominal discomfort
• Uncommon (0.1% to 1%): Abdominal pain upper, dry mouth
• Rare (less than 0.1%): Abdominal distension, dysgeusia, flatulence
• Frequency not reported: Gastralgia^[Ref]

Ocular

• Common (1% to 10%): Eye pain, conjunctivitis
• Rare (less than 0.1%): Abnormal sensation in eye, visual disturbance
• Postmarketing reports: Vision blurred^[Ref]

Oncologic

• Frequency not reported: Tumor flare, exacerbation of disease symptoms
• Postmarketing reports: Pituitary adenoma^[Ref]

Tumor flare occurred in 5% or less of patients, usually manifested by an increase in urinary symptoms and metastatic pain.^[Ref]

Endocrine

• Postmarketing reports: Pituitary apoplexy^[Ref]

The majority of pituitary apoplexy cases occurred within 2 weeks of the first dose, some within the first hour. In these cases, pituitary apoplexy presented as sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status, and sometimes cardiovascular collapse. Immediate medical attention has been required.^[Ref]

See also:

Frequently asked questions

• What is Triptodur used to treat?
• How long can I take Trelstar (triptorelin) for prostate cancer?
• Why is triptorelin used for prostate cancer?

Further information

Triptodur side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer