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Triptodur Side Effects

Generic name: triptorelin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 2, 2023.

Note: This document contains side effect information about triptorelin. Some dosage forms listed on this page may not apply to the brand name Triptodur.

Applies to triptorelin: intramuscular powder for suspension, intramuscular powder for suspension 6 month.

Serious side effects of Triptodur

Along with its needed effects, triptorelin (the active ingredient contained in Triptodur) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking triptorelin:

More common

For children

  • Diarrhea
  • loss of appetite
  • nausea
  • stomach pain
  • weakness

Less common

For children

  • Anxiety
  • body aches or pain
  • chest tightness
  • chills
  • cough
  • cough producing mucus
  • difficulty with breathing
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of voice
  • mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
  • muscle aches and pains
  • nasal congestion
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

For adult men

  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • chest pain or tightness
  • cough producing mucus
  • decrease in urine volume or frequency of urination
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • difficulty in passing urine
  • dizziness
  • dry mouth
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • lower back or side pain
  • nausea
  • nervousness
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • slow or fast heartbeat
  • stomach ache
  • sweating
  • tingling of the hands or feet
  • trouble breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Incidence not known

For children

  • Blurred or loss of vision
  • change in ability to see colors, especially blue or yellow
  • depression
  • difficulty with swallowing
  • disturbed color perception
  • dizziness
  • double vision
  • eye pain
  • halos around lights
  • hives, itching, skin rash
  • nervousness
  • night blindness
  • overbright appearance of lights
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • slow or fast heartbeat
  • thoughts of killing oneself

For adult men

  • Anxiety
  • changes in skin color
  • changes in vision
  • chest discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness or lightheadedness
  • fainting
  • inability to speak
  • irregular heartbeat
  • numbness or tingling in the face, arms, or legs
  • pain
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, redness, or swelling in the arm or leg
  • seizures
  • severe or sudden headache
  • slow heart rate
  • slurred speech
  • temporary blindness
  • tenderness
  • trouble speaking, thinking, or walking
  • weakness in the arm or leg on one side of the body, sudden and severe

Other side effects of Triptodur

Some side effects of triptorelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For children

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • stuffy or runny nose

For adult men

  • Bone pain
  • chills
  • decrease in testicle size
  • decreased interest in sexual intercourse
  • diarrhea
  • feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  • fever
  • general feeling of discomfort or illness
  • inability to have or keep an erection
  • joint pain
  • leg pain
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • muscle aches and pains
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • shivering
  • sore throat
  • sudden sweating
  • trouble sleeping

Less common

For children

  • Change in hearing
  • dryness or soreness of the throat
  • ear drainage
  • earache
  • hoarseness
  • itching of the ears
  • pain or tenderness around the eyes and cheekbones
  • tender, swollen glands in the neck
  • voice changes

For adult men

  • Back pain
  • belching
  • body aches or pain
  • breast pain
  • burning, dry, or itching eyes
  • congestion
  • crying
  • depersonalization
  • difficulty having a bowel movement
  • difficulty with moving
  • discharge or excessive tearing
  • dysphoria
  • euphoria
  • eye pain
  • heartburn
  • hoarseness
  • indigestion
  • injection site pain
  • itching or rash
  • lack or loss of strength
  • leg cramps
  • loss of appetite
  • muscle aching or cramping
  • muscle pains or stiffness
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • stomach discomfort, upset, or pain
  • swelling of the breasts or breast soreness in both females and males
  • swollen joints
  • tender, swollen glands in the neck
  • trouble swallowing
  • voice changes
  • weight loss

For Healthcare Professionals

Applies to triptorelin: intramuscular powder for injection, intramuscular powder for injection extended release.


The most common adverse events were hot flushes, impotence, decreased libido, skeletal pain, and headache.[Ref]


Very common (10% or more): Hot flush (73%), hypertension (14%)

Common (1% to 10%): Dependent edema

Uncommon (0.1% to 1%): Embolism

Rare (less than 0.1%): Hypotension

Postmarketing reports: Blood pressure increased, thromboembolic events including, but not limited to, pulmonary emboli, cerebrovascular accident, myocardial infarction, deep venous thrombosis, transient ischemic attack, and thrombophlebitis[Ref]


Very common (10% or more): Impotence (40%), urinary tract infection (12%), erectile dysfunction (10%), dysuria; women: dyspareunia, dysmenorrhea, ovarian hyperstimulation syndrome, ovarian hypertrophy, pelvic pain, vulvovaginal dryness, bleeding/spotting, genital hemorrhage (including menorrhagia and metrorrhagia)

Common (1% to 10%): Testicular atrophy, breast pain, gynecomastia, urinary retention, vaginal bleeding (children)

Uncommon (0.1% to 1%): Testicular pain, vaginal discharge (children)

Rare (less than 0.1%): Ejaculation failure

Frequency not reported: Testosterone levels increased, testosterone levels decreased, worsening of urethral or bladder outlet obstruction, worsening of symptoms of endometriosis

Postmarketing reports: Amenorrhea[Ref]

At the beginning of treatment, endometriosis symptoms including pelvic pain and dysmenorrhea are commonly exacerbated due to an initial transient increase in plasma estradiol levels. These symptoms are transient and usually disappear in one to two weeks.[Ref]


Very common (10% or more): Decreased libido (40%), sleep disorders, mood changes

Common (1% to 10%): Insomnia, emotional lability, loss of libido, depression, depressed mood, irritability

Rare (less than 0.1%): Confusional state, decreased activity, euphoric mood

Postmarketing reports: Anxiety, affect lability, nervousness[Ref]


Very common (10% or more): Decreased hemoglobin, decreased red blood count

Common (1% to 10%): Anemia

Frequency not reported: Increased lymphocyte count[Ref]


Very common (10% or more): Increased AST, increased ALT, increased alkaline phosphatase, increased hepatic transaminases

Common (1% to 10%): Abnormal hepatic function

Uncommon (0.1% to 1%): Gama-glutamyl transferase increased

Rare (less than 0.1%): Blood alkaline phosphatase increased[Ref]


Very common (10% or more): Increased glucose

Common (1% to 10%): Diabetes mellitus/hyperglycemia, anorexia

Uncommon (0.1% to 1%): Weight increased, gout, increased appetite, weight decreased[Ref]


Very common (10% or more): Increased BUN

Uncommon (0.1% to 1%): Blood creatinine increased

Frequency not reported: Worsening hematuria, decreased kidney function[Ref]


Very common (10% or more): Influenza (16%)

Common (1% to 10%): Bronchitis, coughing, dyspnea, pharyngitis

Uncommon (0.1% to 1%): Asthma aggravated

Rare (less than 0.1%): Orthopnea, epistaxis, nasopharyngitis[Ref]


Very common (10% or more): Skeletal pain (13%), back pain (11%)

Common (1% to 10%): Pain in extremity, arthralgia, edema in legs, leg cramps, myalgia, musculoskeletal pain, muscle spasms

Uncommon (0.1% to 1%): Muscle cramp, muscular weakness

Rare (less than 0.1%): Joint stiffness, joint swelling, musculoskeletal stiffness, osteoarthritis

Frequency not reported: Worsening of bone pain, increased bone loss, osteoporosis, bone fracture, bone disorder, epiphysiolysis, slipped capital femoral epiphysis

Postmarketing reports: Bone pain[Ref]

Nervous system

Very common (10% or more): Paresthesia in lower limbs

Common (1% to 10%): Headache, dizziness, fatigue

Uncommon (0.1% to 1%): Tinnitus, somnolence, paresthesia

Rare (less than 0.1%): Vertigo, dysstasia, memory impairment

Frequency not reported: Worsening of neuropathy, spinal cord compression with weakness or paralysis of the lower extremities

Postmarketing reports: Convulsions[Ref]


Very common (10% or more): Asthenia

Common (1% to 10%): Leg pain, peripheral edema, leg pain, back pain, fatigue, chest pain, edema

Uncommon (0.1% to 1%): Lethargy, pain, rigors, blood lactate dehydrogenase increased, blood cholesterol increased

Rare (less than 0.1%): Pyrexia, influenza like illness, body temperature increased

Frequency not reported: Chills

Postmarketing reports: Malaise[Ref]


Very common (10% or more): Hyperhidrosis

Common (1% to 10%): Rash, pruritus

Uncommon (0.1% to 1%): Acne, alopecia, hypotrichosis

Rare (less than 0.1%): Purpura, blister

Postmarketing reports: Angioneurotic edema, urticaria[Ref]


Common (1% to 10%): Hypersensitivity reaction

Uncommon (0.1% to 1%): Allergic reactions

Rare (less than 0.1%): Anaphylactic reaction, hypersensitivity

Frequency not reported: Anaphylactic shock, angioedema[Ref]


Common (1% to 10%): Injection site pain, injection site reactions, injection site erythema, injection site inflammation[Ref]


Common (1% to 10%): Nausea, vomiting, constipation, dyspepsia, diarrhea, abdominal pain, abdominal discomfort

Uncommon (0.1% to 1%): Abdominal pain upper, dry mouth

Rare (less than 0.1%): Abdominal distension, dysgeusia, flatulence

Frequency not reported: Gastralgia[Ref]


Common (1% to 10%): Eye pain, conjunctivitis

Rare (less than 0.1%): Abnormal sensation in eye, visual disturbance

Postmarketing reports: Vision blurred[Ref]


Frequency not reported: Tumor flare, exacerbation of disease symptoms

Postmarketing reports: Pituitary adenoma[Ref]

Tumor flare occurred in 5% or less of patients, usually manifested by an increase in urinary symptoms and metastatic pain.[Ref]


Postmarketing reports: Pituitary apoplexy[Ref]

The majority of pituitary apoplexy cases occurred within 2 weeks of the first dose, some within the first hour. In these cases, pituitary apoplexy presented as sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status, and sometimes cardiovascular collapse. Immediate medical attention has been required.[Ref]

Frequently asked questions


1. Product Information. Trelstar (triptorelin). Pharmacia and Upjohn. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.