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Alkylating agents

What are Alkylating agents?

Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from linking as they should. This causes breakage of the DNA strands, affecting the ability of the cancer cell to multiply. Eventually, the cancer cell dies. Alkylating agents were one of the first classes of drugs to be used against cancer. There are five traditional categories of alkylating agents:

  • Nitrogen mustards (eg, bendamustine, chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan)
  • Nitrosoureas (eg, carmustine, lomustine, streptozocin)
  • Alkyl sulfonates (eg, busulfan)
  • Triazines (eg, dacarbazine, temozolomide)
  • Ethylenimines (eg, altretamine, thiotepa)

Trabectedin is classed as a tetrahydroisoquinoline alkaloid, and unlike traditional alkylating agents, it binds to the minor groove of DNA and alkylates guanine at the N2 position. Alkylating agents are effective during every phase of the life cycle of a cancer cell, which means they are effective for treating a wide range of cancers. They are most effective for treating slow-growing cancers such as leukemia and solid tumors, but are also used in the treatment of breast, lung, ovarian, and prostate cancers; lymphomas, myelomas, and sarcomas; and Hodgkin's disease. Because alkylating agents affect all cells that are dividing frequently, they are also toxic to normal cells, particularly those of the gastrointestinal tract, bone marrow, testicles, and ovaries. Note: Although the platinum-containing anticancer agents, carboplatin, cisplatin, and oxaliplatin are frequently classified as alkylating agents, they are not. They cause covalent DNA adducts by another means.

List of Alkylating agents:

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Cytoxan (Pro)
Generic name: cyclophosphamide
9.8
7 reviews
Temodar (Pro)
Generic name: temozolomide
7.8
6 reviews
Leukeran (Pro)
Generic name: chlorambucil
8.8
3 reviews
Paraplatin (Pro)
Generic name: carboplatin
9.0
2 reviews
Myleran (Pro)
Generic name: busulfan
10
2 reviews
Treanda (Pro)
Generic name: bendamustine
9.5
1 review
Platinol (Pro)
Generic name: cisplatin
8.0
1 review
Zepzelca (Pro)
Generic name: lurbinectedin
No reviews
Zanosar (Pro)
Generic name: streptozocin
No reviews
Yondelis (Pro)
Generic name: trabectedin
No reviews
Thioplex
Generic name: thiotepa
No reviews
Tepadina (Pro)
Generic name: thiotepa
No reviews
Platinol-AQ (Pro)
Generic name: cisplatin
No reviews
Pepaxto (Pro)
Generic name: melphalan flufenamide
No reviews
Neosar
Generic name: cyclophosphamide
8.0
No reviews
Mustargen (Pro)
Generic name: mechlorethamine
No reviews
Ifex (Pro)
Generic name: ifosfamide
No reviews
Gliadel (Pro)
Generic name: carmustine
No reviews
Gleostine (Pro)
Generic name: lomustine
No reviews
Evomela (Pro)
Generic name: melphalan
No reviews
Eloxatin (Pro)
Generic name: oxaliplatin
No reviews
DTIC-Dome
Generic name: dacarbazine
No reviews
Cytoxan Lyophilized
Generic name: cyclophosphamide
No reviews
CeeNU (Pro)
Generic name: lomustine
No reviews
CCNSB Capsules
Generic name: lomustine
No reviews
Busulfex (Pro)
Generic name: busulfan
1.0
No reviews
BiCNU (Pro)
Generic name: carmustine
No reviews
Bendeka (Pro)
Generic name: bendamustine
No reviews
Belrapzo (Pro)
Generic name: bendamustine
No reviews
Alkeran (Pro)
Generic name: melphalan
4.0
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

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