Skip to Content

Medications for Multiple Myeloma

Other names: Cancer, Malignant Plasmacytoma; Cancer, Multiple Myeloma; Cancer, Plasma Cell Dyscrasia; Cancer, Plasma Cell Myeloma; Malignant Plasmacytoma; Myeloma, Multiple; Plasma Cell Dyscrasia; Plasma Cell Myeloma; Plasmacytoma of Bone

What is Multiple Myeloma?

Multiple myeloma is a type of cancer that forms in plasma cells (also called mature B-lymphocytes), which are a type of white blood cell that is made in the bone marrow. These plasma cells produce a specific type of antibody that helps to fight infections.

Myeloma develops when plasma cells undergo a cancerous change and turn into myeloma cells. These myeloma cells multiply randomly and without order, forming collections of cells called tumors that accumulate most commonly in the bone marrow and on the surfaces of different bones in the body.

These crowd the bone marrow and prevent it from making antibodies and other blood cells, such as red cells, white cells, and platelets.

Myeloma cells secrete chemicals that stimulate osteoclasts (which are cells that break down bone, removing calcium). This causes bones to become weaker and more brittle, which mean they fracture more easily.

Myeloma cells also produce an abnormal type of immunoglobulin that can be detected in the blood. This immunoglobulin may also be called monoclonal immunoglobulin, myeloma protein, or simply M protein. The myeloma type is described by which type of excess immunoglobulin is produced (heavy or light chain myeloma).

Multiple myeloma is considered a rare type of cancer,

What are the Symptoms of Multiple Myeloma?

Early in the disease process, multiple myeloma may not cause any symptoms, and even after diagnosis, treatment may not be needed immediately.

But as it progresses, symptoms of multiple myeloma can include:

  • Bone pain, often in the back and ribs
  • Extreme fatigue
  • Easy bruising due to low platelets
  • Anemia
  • Loss of appetite
  • Stomach problems like nausea and vomiting
  • Mental changes like confusion
  • Increased susceptibility to infections
  • Bone fractures
  • Dehydration
  • Kidney problems.

How is Multiple Myeloma Diagnosed?

Symptoms of multiple myeloma usually don't appear until the disease is more advanced. However, in some cases, your doctor might suspect multiple myeloma based on a blood or urine test taken for another reason.

The following tests may be used during the diagnosis of multiple myeloma:

  • Blood tests (CBC) to look for blood cell counts and certain proteins
  • Urine tests to also look for proteins
  • Bone marrow biopsy to look for myeloma cells
  • Imaging tests such as X-rays, MRI, CT or positron emission tomography (PET)
  • Other tests and procedures may be used as well, depending upon your circumstances.

How is Multiple Myeloma Treated?

The treatment for multiple myeloma may include:

  • Targeted or biologic drug therapy
  • Chemotherapy
  • Stem cell transplant
  • Radiation
  • Surgery
  • Bisphosphonates
  • Corticosteroids.

Drugs Used to Treat Multiple Myeloma

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Revlimid X N 11 reviews
6.0

Generic name: lenalidomide systemic

Drug class: miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

dexamethasone C N 1 review
1.0

Generic name: dexamethasone systemic

Brand names:  Dexamethasone Intensol, Dexpak Taperpak, De-Sone LA, Dxevo …show all

Drug class: glucocorticoids

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Velcade D N 4 reviews
8.4

Generic name: bortezomib systemic

Drug class: proteasome inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Pomalyst X N 3 reviews
10

Generic name: pomalidomide systemic

Drug class: miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Dexamethasone Intensol C N Add review
0.0

Generic name: dexamethasone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

thalidomide X N X Add review
0.0

Generic name: thalidomide systemic

Brand name:  Thalomid

Drug class: leprostatics, miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

cyclophosphamide D N 2 reviews
0.0

Generic name: cyclophosphamide systemic

Drug class: alkylating agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

lenalidomide X N 11 reviews
6.0

Generic name: lenalidomide systemic

Brand name:  Revlimid

Drug class: miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

Thalomid X N X Add review
0.0

Generic name: thalidomide systemic

Drug class: leprostatics, miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

bortezomib D N 5 reviews
8.3

Generic name: bortezomib systemic

Brand name:  Velcade

Drug class: proteasome inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Kyprolis D N 2 reviews
3.5

Generic name: carfilzomib systemic

Drug class: proteasome inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Alkeran D N Add review
4.0

Generic name: melphalan systemic

Drug class: alkylating agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

pomalidomide X N 3 reviews
10

Generic name: pomalidomide systemic

Brand name:  Pomalyst

Drug class: miscellaneous antineoplastics, other immunosuppressants

For consumers: dosage, interactions,

For professionals: AHFS DI Monograph

carfilzomib D N 2 reviews
3.5

Generic name: carfilzomib systemic

Brand name:  Kyprolis

Drug class: proteasome inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

daratumumab N 5 reviews
7.0

Generic name: daratumumab systemic

Brand name:  Darzalex

Drug class: CD38 monoclonal antibodies

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

melphalan D N Add review
4.0

Generic name: melphalan systemic

Brand names:  Alkeran, Evomela

Drug class: alkylating agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Adriamycin D N Add review
0.0

Generic name: doxorubicin systemic

Drug class: antibiotics/antineoplastics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Darzalex N 1 review
5.5

Generic name: daratumumab systemic

Drug class: CD38 monoclonal antibodies

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Dexpak Taperpak C N Add review
0.0

Generic name: dexamethasone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Ninlaro N 1 review
4.0

Generic name: ixazomib systemic

Drug class: proteasome inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

De-Sone LA C N Add review
0.0

Generic name: dexamethasone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

Dxevo C N Add review
0.0

Generic name: dexamethasone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Empliciti N Add review
0.0

Generic name: elotuzumab systemic

Drug class: miscellaneous antineoplastics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Farydak N Add review
0.0

Generic name: panobinostat systemic

Drug class: histone deacetylase inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Mozobil D N Add review
0.0

Generic name: plerixafor systemic

Drug class: hematopoietic stem cell mobilizer, other immunostimulants

For consumers: dosage, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Topics under Multiple Myeloma

Learn more about Multiple Myeloma

IBM Watson Micromedex

Symptoms and treatments

Mayo Clinic Reference

ICD-10 CM Clinical Codes (External)

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Treatment Options

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide