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Idecabtagene vicleucel

Generic name: idecabtagene vicleucel [ EYE-de-KAB-ta-jeen-vik-LOO-sel ]
Brand name: Abecma
Dosage form: intravenous suspension (-)
Drug class: Miscellaneous antineoplastics

Medically reviewed by on Jun 5, 2023. Written by Cerner Multum.

What is idecabtagene vicleucel?

Idecabtagene vicleucel is an immunotherapy medicine used to treat multiple myeloma in adults. idecabtagene vicleucel is given after at least four other treatments have failed.

Idecabtagene vicleucel is made using white blood cells removed from blood.

Idecabtagene vicleucel is available under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Idecabtagene vicleucel may also be used for purposes not listed in this medication guide.

Idecabtagene vicleucel side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

A serious side effect of idecabtagene vicleucel is called cytokine release syndrome (CRS). Tell your caregivers right away if you have signs of this condition: fever, chills, trouble breathing, severe vomiting or diarrhea, tremors, shaking, fast or irregular heartbeats, feeling light-headed, or feeling very tired. Your caregivers will have medication available to quickly treat CRS if it occurs.

Also tell your caregivers or seek emergency medical attention if you have signs of life-threatening nerve problems: problems with speech, problems with thinking or memory, confusion, or a seizure.

Also call your doctor at once if you have:

Common side effects of idecabtagene vicleucel may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


A serious side effect of idecabtagene vicleucel is called cytokine release syndrome, which causes fever, chills, trouble breathing, vomiting, and other symptoms. Your caregivers will have medication available to quickly treat this condition if it occurs.

Idecabtagene vicleucel can also cause life-threatening nerve problems. Tell your caregivers or seek emergency medical attention if you have problems with speech, problems with thinking or memory, confusion, or a seizure.

Before taking this medicine

Tell your doctor if you have ever had:

Women may need pregnancy testing before receiving this medicine. You may also need to use birth control to prevent pregnancy during and shortly after treatment with idecabtagene vicleucel and chemotherapy.

If you receive idecabtagene vicleucel during pregnancy, your baby's blood may need to be tested after it is born. This is to evaluate any effects the medicine may have had on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use idecabtagene vicleucel?

Idecabtagene vicleucel is available only at an authorized hospital or clinic, and must be given by specially trained healthcare professionals.

Idecabtagene vicleucel is given after a procedure called leukapheresis (LOO-kuh-fuh-REE-sis).

During leukapheresis, some of your blood is collected through a small tube (catheter) placed into a vein. The catheter is connected to a machine that separates your white blood cells from other parts of the blood. The cells are then sent to a laboratory where they are made into idecabtagene vicleucel, a process that will take 4 weeks.

About 3 days before idecabtagene vicleucel is given, you will be pre-treated with chemotherapy to help prepare your body for idecabtagene vicleucel.

Just before you receive idecabtagene vicleucel, you will be given other medications to help prevent serious side effects or allergic reaction.

Once your body is ready to receive idecabtagene vicleucel, your care providers will inject the medicine into a vein through an IV.

You will be watched closely for at least 7 days after you receive idecabtagene vicleucel, to make sure you do not have an allergic reaction or serious side effects.

You will need frequent blood tests to be sure idecabtagene vicleucel has not caused harmful effects.

Using idecabtagene vicleucel may increase your risk of developing other cancers. Ask your doctor about this risk. You may need cancer screening tests for the rest of your life.

Idecabtagene vicleucel may cause false results on a laboratory test for human immunodeficiency virus (HIV). Tell any doctor who treats you that you are using idecabtagene vicleucel.

For at least 4 weeks, plan to stay near the hospital or clinic where you received idecabtagene vicleucel. Avoid being so far away that it takes you longer than 2 hours to travel back to the hospital.

What happens if I miss a dose?

Call your doctor for instructions if you miss any of your chemotherapy treatment, or if you miss a dose of your medications to prevent side effects of idecabtagene vicleucel.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while using idecabtagene vicleucel?

idecabtagene vicleucel can cause weakness, drowsiness, confusion, problems with memory or coordination, and seizures. Avoid driving or operating machinery for at least 8 weeks after you are treated with idecabtagene vicleucel.

Ask your doctor before you receive a "live" vaccine. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Do not donate blood, an organ, or any tissues or cells.

What other drugs will affect idecabtagene vicleucel?

Other drugs may affect idecabtagene vicleucel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.