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Darzalex

Generic Name: daratumumab (DAR a TOOM ue mab)
Brand Names: Darzalex

Medically reviewed on Oct 10, 2018

What is Darzalex?

See also: Pomalyst

Darzalex (daratumumab) is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Darzalex is used to treat multiple myeloma (bone marrow cancer). Daratumumab is usually given after other treatments have failed.

Darzalex is sometimes used in combination with other cancer medicines plus a steroid medicine called dexamethasone.

Important Information

If you need to receive a blood transfusion, be sure to tell your caregivers that you are being treated with Darzalex.

Darzalex side effects

Get emergency medical help if you have signs of an allergic reaction to Darzalex: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, itchy, nauseated, or if you have a headache, stuffy nose, runny nose, cough, fever, chills, wheezing, trouble breathing, or a tight feeling in your throat.

Call your doctor at once if you have:

  • cough with yellow or green mucus;

  • stabbing chest pain, wheezing, feeling short of breath;

  • nerve problems - numbness, tingling, burning pain; or

  • low blood cell counts - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Darzalex side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking this medicine

You should not be treated with Darzalex if you are allergic to daratumumab.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

Daratumumab may harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How is Darzalex given?

Darzalex is given as an infusion into a vein. A healthcare provider will give you this injection.

Darzalex is usually given every 1 to 3 weeks during the first several weeks of treatment. Then it is given once every 4 weeks until your body no longer responds to the medicine. Your doctor will determine how long to treat you with this medicine.

You may be given other medications to help prevent serious side effects or an allergic reaction. Keep using these medicines for as long as your doctor has prescribed.

You will need frequent medical tests.

Daratumumab can affect blood tests that are used to match your blood type. If you need to receive a blood transfusion, be sure to tell your caregivers that you are being treated with Darzalex.

Daratumumab can affect blood-typing tests for up to 6 months after you stop using this medicine.

Darzalex dosing information

The recommended dose of daratumumab is 16 mg/kg actual body weight according to the following schedule.

Monotherapy and in combination with lenalidomide or pomalidomide and low-dose dexamethasone:

  • Weeks 1 to 8 - weekly (total of 8 doses)
  • Weeks 9 to 24 - every two weeks (total of 8 doses)
  • Week 25 onwards until disease progression - every four weeks

In combination with bortezomib and dexamethasone:

  • Weeks 1 to 9 - weekly (total of 9 doses)
  • Weeks 10 to 24 - every three weeks (total of 5 doses)
  • Week 25 onwards until disease progression - every four weeks

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Darzalex injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Darzalex?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Darzalex?

Other drugs may interact with daratumumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

  • Darzalex is manufactured by Janssen Biotech, Inc. Your doctor or pharmacist can provide more information.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Darzalex only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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