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Cyclophosphamide Dosage

Medically reviewed by Drugs.com. Last updated on Nov 28, 2023.

Applies to the following strengths: 100 mg; 200 mg; 500 mg; 1 g; 2 g; 50 mg; 25 mg; lyophilized 100 mg; lyophilized 200 mg; lyophilized 500 mg; lyophilized 1 g; lyophilized 2 g; 100 mg/mL; 500 mg/mL; 1 g/2 mL; 2 g/4 mL; 200 mg/mL

Usual Adult Dose for Malignant Disease

IV:


Oral: 1 to 5 mg/kg/day (initial and maintenance dosing)

Comments:

Uses:

Usual Pediatric Dose for Malignant Disease

The doses below can be regarded as general guidelines:

IV:


Oral: 1 to 5 mg/kg/day (initial and maintenance dosing)

Comments:

Uses:

Usual Pediatric Dose for Nephrotic Syndrome

The doses below can be regarded as general guidelines:
2 mg/kg orally daily for 8 to 12 weeks (maximum cumulative dose 168 mg/kg); treatment beyond 90 days increases the probability of sterility in males

Comments:


Use: For the treatment of biopsy proven minimal change nephrotic syndrome in pediatric patients who failed to adequately respond to or are unable to tolerate adrenocorticosteroid therapy

Renal Dose Adjustments

Liver Dose Adjustments

Dose Adjustments

Perform regular leukocyte and platelet counts during therapy with this drug. The dose should be adjusted, if required, if myelosuppression becomes evident:

Precautions

CONTRAINDICATIONS:


Consult WARNINGS section for additional precautions.

Dialysis

This drug and its metabolites are dialyzable although there are probably quantitative differences depending upon the dialysis system being used. In patients requiring dialysis, use of a consistent interval between administration of this drug and dialysis should be considered.

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:
procedures.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.